Gene expression is tightly controlled at multiple levels by different categories of cis-regulatory elements(CREs)and transacting factors(TAFs).Two different regulators might have additive or even synergistic effects,e...Gene expression is tightly controlled at multiple levels by different categories of cis-regulatory elements(CREs)and transacting factors(TAFs).Two different regulators might have additive or even synergistic effects,enabling robust repression or activation of target gene expression(i.e.f the"fail-safe"regulation).Alternatively,two regulators might antagonistically regulate the same targets,which seems futile,but could stabilize gene expression.As a transcript could be regulated by multiple mechanisms,the combinatorial use of different categories of CREs and TAFs might be prevalent in modulating the function and fate of an mRNA[1,2].展开更多
基金the Ministry of Science and Technology of the People’s Republic of China(2016YFA0500800)the National Natural Science Foundation of China(91731301)+1 种基金the China Postdoctoral Science Foundation(2019M650003)the National Postdoctoral Innovative Talents Supporting Program。
文摘Gene expression is tightly controlled at multiple levels by different categories of cis-regulatory elements(CREs)and transacting factors(TAFs).Two different regulators might have additive or even synergistic effects,enabling robust repression or activation of target gene expression(i.e.f the"fail-safe"regulation).Alternatively,two regulators might antagonistically regulate the same targets,which seems futile,but could stabilize gene expression.As a transcript could be regulated by multiple mechanisms,the combinatorial use of different categories of CREs and TAFs might be prevalent in modulating the function and fate of an mRNA[1,2].
