Cerebral ischemia seriously affects the quality of life and health of human worldwide.W026B is a newly synthesized lignan derivative that has a protective effect on the focal cerebral ischemia/reperfusion model,while ...Cerebral ischemia seriously affects the quality of life and health of human worldwide.W026B is a newly synthesized lignan derivative that has a protective effect on the focal cerebral ischemia/reperfusion model,while it is unclear whether W026B has a cerebral protective effect on the model of global cerebral ischemia/reperfusion(GCI/R).In this study,we investigated the protective effect of W026B on the four-vessel occlusion GCI/R model.The results showed that W026B obviously increased the survival rate of rats during 7 d after GCI/R and significantly improved neurological deficits within 7 d after GCI/R.It evidently enhanced the number of survival neurons in the hippocampus of GCI/R rats.Furthermore,W026B notably lowered the level of ROS,and increased the activity of SOD in the hippocampus of GCI/R rats.Moreover,it also decreased the expression of NF-κB p65 and the level of IL-6 apparently.In addition,W026B evidently lowered the activity of caspase-3.In conclusion,this study firstly proves that W026B has the protective effect on GCI/R rats.Its cerebral protective effect maybe related to the inhibition of oxidative stress,inflammatory response,and cell apoptosis during GCI/R.These results provide new evidence with the protective effect of W026B on cerebral ischemia/reperfusion injury.展开更多
基金National Natural Science Foundation of China(Grant No.81503060,81573333)R&D Foundation of Beijing Honghui New Medical Technology Co.,Ltd。
文摘Cerebral ischemia seriously affects the quality of life and health of human worldwide.W026B is a newly synthesized lignan derivative that has a protective effect on the focal cerebral ischemia/reperfusion model,while it is unclear whether W026B has a cerebral protective effect on the model of global cerebral ischemia/reperfusion(GCI/R).In this study,we investigated the protective effect of W026B on the four-vessel occlusion GCI/R model.The results showed that W026B obviously increased the survival rate of rats during 7 d after GCI/R and significantly improved neurological deficits within 7 d after GCI/R.It evidently enhanced the number of survival neurons in the hippocampus of GCI/R rats.Furthermore,W026B notably lowered the level of ROS,and increased the activity of SOD in the hippocampus of GCI/R rats.Moreover,it also decreased the expression of NF-κB p65 and the level of IL-6 apparently.In addition,W026B evidently lowered the activity of caspase-3.In conclusion,this study firstly proves that W026B has the protective effect on GCI/R rats.Its cerebral protective effect maybe related to the inhibition of oxidative stress,inflammatory response,and cell apoptosis during GCI/R.These results provide new evidence with the protective effect of W026B on cerebral ischemia/reperfusion injury.
