目的:运用中医传承辅助系统(Traditional Chinese Medicine Inheritance Support System,TCMISS)软件,挖掘分析中国知网(China National Knowledge Infrastructure,CNKI)近10年运用中医药治疗胃癌的用药规律。方法:搜索CNKI数据库中运...目的:运用中医传承辅助系统(Traditional Chinese Medicine Inheritance Support System,TCMISS)软件,挖掘分析中国知网(China National Knowledge Infrastructure,CNKI)近10年运用中医药治疗胃癌的用药规律。方法:搜索CNKI数据库中运用中医药治疗胃癌的文献,将符合纳入标准的文献方剂手动输入TCMISS软件,建立处方数据库,再应用频次统计、关联规则、熵聚类分析法等方法挖掘中医药治疗胃癌的组方用药规律。结果:收集中医药治疗胃癌的方剂182首,包含中药233味。其中甘温药物的使用频次最高,归脾经药物使用频次最高;利用关联规则分析得出核心药物4个,常用药物组合3组;通过关联规则分析,置信度≥0.85的有13条规则;通过无监督的熵层次聚类算法,演化出18组核心药物组合,进一步聚类得到9个新处方。结论:治疗胃癌的药物多具有补气健脾、祛湿化痰、解毒散结等功效,符合中医药治疗胃癌的理论基础,反映出脾胃虚弱、痰湿内蕴是导致胃癌发生发展的重要病机。展开更多
This paper presents a novel high precision and wide range adjustable LED constant-current drive controller design.Compared with the traditional technique,the conventional mirror resistance is substituted by a MOSFET w...This paper presents a novel high precision and wide range adjustable LED constant-current drive controller design.Compared with the traditional technique,the conventional mirror resistance is substituted by a MOSFET with fixed drain voltage,and a negative feedback amplifier is used to keep all mirror device voltages equal,so that the output current is precise and not affected by the load supply voltage.In addition,the electric property of the mirror MOSFET is optimized by a current subsection mirror（CSM） mechanism,thus ensuring a wide range of output current with high accuracy.A three-channel LED driver chip based on this project is designed and fabricated in the TSMC 0.6μm BCD process with a die area of 1.1×0.7 mm^2.Experimental results show that the proposed LED drive controller works well, and,as expected,the output current can be maintained from 5 to 60 mA.A relative current accuracy error of less than 1%and a maximal relative current matching error of 1.5%are successfully achieved.展开更多
文摘目的:运用中医传承辅助系统(Traditional Chinese Medicine Inheritance Support System,TCMISS)软件,挖掘分析中国知网(China National Knowledge Infrastructure,CNKI)近10年运用中医药治疗胃癌的用药规律。方法:搜索CNKI数据库中运用中医药治疗胃癌的文献,将符合纳入标准的文献方剂手动输入TCMISS软件,建立处方数据库,再应用频次统计、关联规则、熵聚类分析法等方法挖掘中医药治疗胃癌的组方用药规律。结果:收集中医药治疗胃癌的方剂182首,包含中药233味。其中甘温药物的使用频次最高,归脾经药物使用频次最高;利用关联规则分析得出核心药物4个,常用药物组合3组;通过关联规则分析,置信度≥0.85的有13条规则;通过无监督的熵层次聚类算法,演化出18组核心药物组合,进一步聚类得到9个新处方。结论:治疗胃癌的药物多具有补气健脾、祛湿化痰、解毒散结等功效,符合中医药治疗胃癌的理论基础,反映出脾胃虚弱、痰湿内蕴是导致胃癌发生发展的重要病机。
基金supported by the National Ministry Pre-Research Foundation of China(No.9140A08010208DZ0123)the Applied Materials Innovation Foundation of Xi'an,China(No.XA-AM-200817)
文摘This paper presents a novel high precision and wide range adjustable LED constant-current drive controller design.Compared with the traditional technique,the conventional mirror resistance is substituted by a MOSFET with fixed drain voltage,and a negative feedback amplifier is used to keep all mirror device voltages equal,so that the output current is precise and not affected by the load supply voltage.In addition,the electric property of the mirror MOSFET is optimized by a current subsection mirror（CSM） mechanism,thus ensuring a wide range of output current with high accuracy.A three-channel LED driver chip based on this project is designed and fabricated in the TSMC 0.6μm BCD process with a die area of 1.1×0.7 mm^2.Experimental results show that the proposed LED drive controller works well, and,as expected,the output current can be maintained from 5 to 60 mA.A relative current accuracy error of less than 1%and a maximal relative current matching error of 1.5%are successfully achieved.
