Hydroxyapatite(HA) coating has been prepared on titanium substrate through an electrochemical deposition approach. In order to improve the bonding strength between HA coating and Ti substrate, a well oriented and unif...Hydroxyapatite(HA) coating has been prepared on titanium substrate through an electrochemical deposition approach. In order to improve the bonding strength between HA coating and Ti substrate, a well oriented and uniform titanium oxide nanotube array on the surface of titanium substrate was applied by means of anodic oxidation pre-treatment. Then the calcium hydrogen phosphate(CaHPO4·2H2O, DCPD) coating, as the precursor of hydroxyapatite coating, was electrodeposited on the anodized Ti. At the initial stage of electro-deposition, the DCPD crystals, in nanometer precipitates, are anchored in and between the tubes. With increasing the deposition time, the nanometer DCPD crystals are connected together to form a continuous coating on titanium oxide nanotube array. Finally, the DCPD coating is converted into hydroxyapatite one simply by being immersed in alkaline solution.展开更多
To evaluate the acute lung toxicity and the effect on serum biochemical indexes of inhaled TiO2 nanotubes , healthy and adult Kunming mice are exposed to aerosols of TiO2nanotubes in a sealed chamber , the concentrati...To evaluate the acute lung toxicity and the effect on serum biochemical indexes of inhaled TiO2 nanotubes , healthy and adult Kunming mice are exposed to aerosols of TiO2nanotubes in a sealed chamber , the concentration of which is 250mg / m 3 while another group of mice are exposed to room air only served as control.The blood , alveolar lavaged fluid and lungs of the mice are collected and examined after exposed for 7 , 14and 28d , respectively.The serum analysis shows that glucose ( Glu ) values with 7dexposure , alanine aminotransferase ( ALT ) and aspartate aminotransferase ( AST ) activities with 28dinhalation , and total bile acid ( TBA ) values with 7 , 28d as well as the creatine kinase ( CK ) levels with 28dexposure are significantly different from those of controls ( P< 0.05 ) .The pathological findings exhibit that more TiO 2 nanotubes are found in the interstitium of pulmonary alveoli with the experimental time prolonged.The results suggest that TiO 2 nanotubes do produce adverse responses to the lung and serum biochemical indexes of mice.Moreover , the responses become severer with the exposed-time prolonged.展开更多
基金Project(BK2004129) supported by the Natural Science Foundation of Jiangsu Province, China
文摘Hydroxyapatite(HA) coating has been prepared on titanium substrate through an electrochemical deposition approach. In order to improve the bonding strength between HA coating and Ti substrate, a well oriented and uniform titanium oxide nanotube array on the surface of titanium substrate was applied by means of anodic oxidation pre-treatment. Then the calcium hydrogen phosphate(CaHPO4·2H2O, DCPD) coating, as the precursor of hydroxyapatite coating, was electrodeposited on the anodized Ti. At the initial stage of electro-deposition, the DCPD crystals, in nanometer precipitates, are anchored in and between the tubes. With increasing the deposition time, the nanometer DCPD crystals are connected together to form a continuous coating on titanium oxide nanotube array. Finally, the DCPD coating is converted into hydroxyapatite one simply by being immersed in alkaline solution.
基金Supported by the Ford University Research Projectthe "Peak of Six Major Human Resources Plan" of Jiangsu Province
文摘To evaluate the acute lung toxicity and the effect on serum biochemical indexes of inhaled TiO2 nanotubes , healthy and adult Kunming mice are exposed to aerosols of TiO2nanotubes in a sealed chamber , the concentration of which is 250mg / m 3 while another group of mice are exposed to room air only served as control.The blood , alveolar lavaged fluid and lungs of the mice are collected and examined after exposed for 7 , 14and 28d , respectively.The serum analysis shows that glucose ( Glu ) values with 7dexposure , alanine aminotransferase ( ALT ) and aspartate aminotransferase ( AST ) activities with 28dinhalation , and total bile acid ( TBA ) values with 7 , 28d as well as the creatine kinase ( CK ) levels with 28dexposure are significantly different from those of controls ( P< 0.05 ) .The pathological findings exhibit that more TiO 2 nanotubes are found in the interstitium of pulmonary alveoli with the experimental time prolonged.The results suggest that TiO 2 nanotubes do produce adverse responses to the lung and serum biochemical indexes of mice.Moreover , the responses become severer with the exposed-time prolonged.
