Objective To find out a new treatment method for advanced pancreatic carcinoma. Methods Twenty nine patients with advanced pancreatic carcinoma and liver metastases were randomly divided into 2 groups.Group A ( n =11)...Objective To find out a new treatment method for advanced pancreatic carcinoma. Methods Twenty nine patients with advanced pancreatic carcinoma and liver metastases were randomly divided into 2 groups.Group A ( n =11) underwent bilio enterostomy and/or gastro enterostomy combined with systemic chemotherapy after operation;Group B( n =18) underwent bilio enterostomy and/or gastro enterostomy combined with peripancreatic arterial ligation and arterial infusion regional chemotherapy.The alleviation of clinical symptom,the change of carcinoma volume by BUS and CT scan,survival period and serum CEA were observed in two groups. Results The symptoms were alleviated apparently in most cases in Group B;BUS and CT scan showed that the tumor volume decreased apparently in Group B;The response rate was 67.7% in Group B,and 18.2% in Group A,respectively( P <0.01);the mean survival period was (4.8±0.6) months in Group A,and (12.5±1.2) months in Group B,respectively( P <0.01),there was significant difference between the two groups.The decrease of serum CEA was 54% in Group A and 60% in Group B,but the difference was not significant( P >0.05). Conclusion Peripancreatic arterial ligation combined with arterial infusion regional chmotherapy is believed to be effective against both pancreatic carcinoma and liver metastases,and it can alleviate the clinical symptoms,postpone the growth speed of tumor,and prolong the survival period.展开更多
To explore a new method for treatment of advanced pancreatic carcinoma (APC).Methods Twenty-nine patiens with APC (12 of them were with liver metastasis at the same time) were randomized into 2 groups.The 11 patients ...To explore a new method for treatment of advanced pancreatic carcinoma (APC).Methods Twenty-nine patiens with APC (12 of them were with liver metastasis at the same time) were randomized into 2 groups.The 11 patients in group A received bilio-enterostomy and/or gastroenterostomy in combination with systemic chemotherapy after operation.The 18 patients in group B underwent bilio-enterostomy and/or gastroenterostomy in combination with peripancreatic arterial ligation and arterial infusion regional chemotherapy.The palliation of clinical symptoms,the changes of carcinoma size were determined by BUS and CT.Survival time and serum CEA level were determined and compared between the 2 groups.Results The symptoms were alleviated apparently in most cases and tumor size significantly decreased in group B.The response rate was 67.7 and 18.2% in group B and group A,respectively (P<0.01).The survival time was 4.8±0.6 months and 12.5±1.2 months in group A and group B,respectively (P<0.01).The decrease of serum CEA was 54% in group A and 60% in group B,respectively (P>0.05).Conclusion Peripancreatic arterial ligation in combination with arterial infusion regional chemotherapy is effective in fighting against both pancreatic carcinoma and liver metastasis.Meanwhile,it can alleviate the clinical symptoms,postpone the growth speed of tumor and prolong the survival time of patients.14 refs,2 tabs.展开更多
文摘Objective To find out a new treatment method for advanced pancreatic carcinoma. Methods Twenty nine patients with advanced pancreatic carcinoma and liver metastases were randomly divided into 2 groups.Group A ( n =11) underwent bilio enterostomy and/or gastro enterostomy combined with systemic chemotherapy after operation;Group B( n =18) underwent bilio enterostomy and/or gastro enterostomy combined with peripancreatic arterial ligation and arterial infusion regional chemotherapy.The alleviation of clinical symptom,the change of carcinoma volume by BUS and CT scan,survival period and serum CEA were observed in two groups. Results The symptoms were alleviated apparently in most cases in Group B;BUS and CT scan showed that the tumor volume decreased apparently in Group B;The response rate was 67.7% in Group B,and 18.2% in Group A,respectively( P <0.01);the mean survival period was (4.8±0.6) months in Group A,and (12.5±1.2) months in Group B,respectively( P <0.01),there was significant difference between the two groups.The decrease of serum CEA was 54% in Group A and 60% in Group B,but the difference was not significant( P >0.05). Conclusion Peripancreatic arterial ligation combined with arterial infusion regional chmotherapy is believed to be effective against both pancreatic carcinoma and liver metastases,and it can alleviate the clinical symptoms,postpone the growth speed of tumor,and prolong the survival period.
文摘To explore a new method for treatment of advanced pancreatic carcinoma (APC).Methods Twenty-nine patiens with APC (12 of them were with liver metastasis at the same time) were randomized into 2 groups.The 11 patients in group A received bilio-enterostomy and/or gastroenterostomy in combination with systemic chemotherapy after operation.The 18 patients in group B underwent bilio-enterostomy and/or gastroenterostomy in combination with peripancreatic arterial ligation and arterial infusion regional chemotherapy.The palliation of clinical symptoms,the changes of carcinoma size were determined by BUS and CT.Survival time and serum CEA level were determined and compared between the 2 groups.Results The symptoms were alleviated apparently in most cases and tumor size significantly decreased in group B.The response rate was 67.7 and 18.2% in group B and group A,respectively (P<0.01).The survival time was 4.8±0.6 months and 12.5±1.2 months in group A and group B,respectively (P<0.01).The decrease of serum CEA was 54% in group A and 60% in group B,respectively (P>0.05).Conclusion Peripancreatic arterial ligation in combination with arterial infusion regional chemotherapy is effective in fighting against both pancreatic carcinoma and liver metastasis.Meanwhile,it can alleviate the clinical symptoms,postpone the growth speed of tumor and prolong the survival time of patients.14 refs,2 tabs.
