The relationship of causeresult between low selenium (Se) and KashinBeck disease (KBD) was probed by the prospective study of epidemiological method with regarding lowSe as an exposure factor in this paper. 597 health...The relationship of causeresult between low selenium (Se) and KashinBeck disease (KBD) was probed by the prospective study of epidemiological method with regarding lowSe as an exposure factor in this paper. 597 healthy children lived in KBD areas with low, middle and high prevalence were divided into the lowSe exposed group and the nonlowSe exposed group according to their Se content in hair. The lowSe exposed group was divided into three subgroups, such as Se content in hair110 ng/g, 110 ng/g<Se content in hair150 ng/g and 150 ng/g<Se content in hair200 ng/g, respectively. Six new cases of the total with KBD (incidence was 0574% personyear) were found in the lowSe exposed group during three years period of the investigation. No new case was found in the non lowSe exposed group . KBD incidence was not significantly different between those two groups. Two new cases were found in children with Se content in hair kept below 110 ng/g during three years (incidence: 121% personyear). SMR in each group indicated that the new cases observed in the lowSe exposed group was remarkable lower than the new cases expected. It was not observed that the doseresponse relationship between lowSe and KBD, and was not supported that the lowSe was a predominant factor to cause KBD.展开更多
文摘The relationship of causeresult between low selenium (Se) and KashinBeck disease (KBD) was probed by the prospective study of epidemiological method with regarding lowSe as an exposure factor in this paper. 597 healthy children lived in KBD areas with low, middle and high prevalence were divided into the lowSe exposed group and the nonlowSe exposed group according to their Se content in hair. The lowSe exposed group was divided into three subgroups, such as Se content in hair110 ng/g, 110 ng/g<Se content in hair150 ng/g and 150 ng/g<Se content in hair200 ng/g, respectively. Six new cases of the total with KBD (incidence was 0574% personyear) were found in the lowSe exposed group during three years period of the investigation. No new case was found in the non lowSe exposed group . KBD incidence was not significantly different between those two groups. Two new cases were found in children with Se content in hair kept below 110 ng/g during three years (incidence: 121% personyear). SMR in each group indicated that the new cases observed in the lowSe exposed group was remarkable lower than the new cases expected. It was not observed that the doseresponse relationship between lowSe and KBD, and was not supported that the lowSe was a predominant factor to cause KBD.
