Tissue implant-related infections are among the most serious complications after surgical implantation,including orthopedics and dentistry.Implants with antibacterial ion release systems are efficient and economical a...Tissue implant-related infections are among the most serious complications after surgical implantation,including orthopedics and dentistry.Implants with antibacterial ion release systems are efficient and economical antibiotic substitutes to fight against bacterial infections.However,the excessive amount of released antibacterial ions may cause biological toxicity while killing bacteria.This raises a fundamental issue on how to properly control the amounts of ions and their efficacy.Here,we develop low-dose antibacterial ions-incorporated ferroelectric implants(copper-doped potassium sodium niobate,K0.5Na0.5NbO3-Cu,KNNCu)whose surface potential can be tuned via external polarization.The released Cu2+ions can be targeted to bacteria via endogenous electric field(EEF)between KNNCu implants and negatively charged bacteria.Intriguingly,the antibacterial efficacy of the implants is determined by the amount of Cu^2+ions that reaches bacteria,instead of the total amount of released Cu2+ions.The amount of Cu2+ions reaching bacteria from the high-surface-potential implant is 2.4 times that from the lowsurface-potential implant within 12 h,resulting in the increased antibacterial ratio from about 65%to 100%,while remaining low cell toxicity.This work provides insights into the specific role of the EEF in guiding mass transport between charged materials and living organisms,and a new perspective for the design of high-performance antibacterial biomaterials.展开更多
In the past few decades,we have seen the rapid development of bioactive materials which can repair damaged tissues and save human lives.Traditionally,researchers have sought to develop bioactive materials with unique ...In the past few decades,we have seen the rapid development of bioactive materials which can repair damaged tissues and save human lives.Traditionally,researchers have sought to develop bioactive materials with unique physical and chemical properties,such as stiffness,functional groups,nanotopographies and stimulus-responsive properties,to promote tissue regeneration at the biointerface.展开更多
基金supported by the National Key R&D Program of China(2018YFC1105304 and 2018YFC1105301)the National Natural Science Foundation of China(51772106,31771080,51702104,51672088 and 31700880)+2 种基金the Natural Science Foundation of Guangdong Province(2016A030308014)the Joint Funds of the National Natural Science Foundation of China(U1501245)the Science and Technology Innovation Team Project of Foshan(2015IT100062)。
文摘Tissue implant-related infections are among the most serious complications after surgical implantation,including orthopedics and dentistry.Implants with antibacterial ion release systems are efficient and economical antibiotic substitutes to fight against bacterial infections.However,the excessive amount of released antibacterial ions may cause biological toxicity while killing bacteria.This raises a fundamental issue on how to properly control the amounts of ions and their efficacy.Here,we develop low-dose antibacterial ions-incorporated ferroelectric implants(copper-doped potassium sodium niobate,K0.5Na0.5NbO3-Cu,KNNCu)whose surface potential can be tuned via external polarization.The released Cu2+ions can be targeted to bacteria via endogenous electric field(EEF)between KNNCu implants and negatively charged bacteria.Intriguingly,the antibacterial efficacy of the implants is determined by the amount of Cu^2+ions that reaches bacteria,instead of the total amount of released Cu2+ions.The amount of Cu2+ions reaching bacteria from the high-surface-potential implant is 2.4 times that from the lowsurface-potential implant within 12 h,resulting in the increased antibacterial ratio from about 65%to 100%,while remaining low cell toxicity.This work provides insights into the specific role of the EEF in guiding mass transport between charged materials and living organisms,and a new perspective for the design of high-performance antibacterial biomaterials.
基金supported by the National Natural Science Foundation of China(51932002,52072127,51773045,21772030,51922032,and 21961160720)the National Natural Science Foundation of China(51773045,21772030,51922032,and 21961160720)for financial support+2 种基金the National Key Research and Development Program of China(2017YFA0206600)the National Key Research and Development Program of China(2017YFA0206600)the Science and Technology Program of Guangzhou(202002030308)。
文摘In the past few decades,we have seen the rapid development of bioactive materials which can repair damaged tissues and save human lives.Traditionally,researchers have sought to develop bioactive materials with unique physical and chemical properties,such as stiffness,functional groups,nanotopographies and stimulus-responsive properties,to promote tissue regeneration at the biointerface.
