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纤维蛋白原基因多态性位点与血浆纤维蛋白原γ′水平及缺血性脑卒中的关系研究 被引量:4
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作者 虞珊珊 丁媛媛 +4 位作者 宗明 张慧 王翰琪 谭琪 范列英 《国际检验医学杂志》 CAS 2015年第20期2932-2933,2936,共3页
目的研究纤维蛋白原(Fib)γ基因多态性位点FGG 9340T〉C(rs1049636)与血浆Fibγ′水平及缺血性脑卒中(IS)易感性的相关性。方法采用病例-对照研究方法,患者组选取华东地区IS患者421例,男283例、女138例,年龄40~88岁,均为汉族,无... 目的研究纤维蛋白原(Fib)γ基因多态性位点FGG 9340T〉C(rs1049636)与血浆Fibγ′水平及缺血性脑卒中(IS)易感性的相关性。方法采用病例-对照研究方法,患者组选取华东地区IS患者421例,男283例、女138例,年龄40~88岁,均为汉族,无亲缘关系;选取性别、年龄与患者组相匹配的个体421例作为对照组;应用双抗夹心酶联免疫吸附测定(ELISA)检测两组人群血浆Fibγ′水平。应用聚合酶链式反应-连接酶检测反应(PCR-LDR)的方法检测rs1049636位点基因型。结果患者组血浆Fibγ′水平[(159.4±97.4)U/dL]明显高于对照组[(114.2±73.0)U/dL],差异有统计学意义(P〈0.001);不论是在患者组还是在对照组,Fib基因rs1049636C等位基因均与高水平的血浆Fibγ′相关;但rs1049636各基因型及等位基因的分布在患者组和对照组间比较,差异均无统计学意义(P=0.077,0.106)。结论血浆Fibγ′可以增加中国人群IS的易感性,FGG基因多态性位点rs1049636C等位基因虽与血浆Fibγ′水平相关,但可能与中国人群IS的发病无关。 展开更多
关键词 缺血性脑卒中 纤维蛋白原γ′ 单核苷酸多态性
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The Discovery of Burst Topic and Its Intermittent Evolution in Our Real World
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作者 汤斯亮 张寅 +3 位作者 王翰琪 陈铭 吴飞 庄越挺 《China Communications》 SCIE CSCD 2013年第3期1-12,共12页
Nowadays, a considerably large number of documents are available over many online news sites (e.g., CNN and NYT). Therefore, the utilization of these online documents, for example, the discovery of a burst topic and i... Nowadays, a considerably large number of documents are available over many online news sites (e.g., CNN and NYT). Therefore, the utilization of these online documents, for example, the discovery of a burst topic and its evolution, is a significant challenge. In this paper, a novel topic model, called intermittent Evolution LDA (iELDA) is proposed. In iELDA, the time-evolving documents are divided into many small epochs. iELDA utilizes the detected global topics as priors to guide the detection of an emerging topic and keep track of its evolution over different epochs. As a natural extension of the traditional Latent Dirichlet Allocation (LDA) and Dynamic Topic Model (DTM), iELDA has an advantage: it can discover the intermittent recurring pattern of a burst topic. We apply iELDA to real-world data from NYT; the results demonstrate that the proposed iELDA can appropriately capture a burst topic and track its intermittent evolution as well as produce a better predictive ability than other related topic models. 展开更多
关键词 LDA time series iterative clustering model
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