目的观察控释地诺前列酮栓与缩宫素应用于足月胎膜早破引产的疗效及护理比较。方法选择64例足月胎膜早破产妇,分为观察组(30例)和对照组(34例),分别采用控释地诺前列酮栓和小剂量缩宫素引产。结果观察组治疗后4 h,12 h Bishop评分上升...目的观察控释地诺前列酮栓与缩宫素应用于足月胎膜早破引产的疗效及护理比较。方法选择64例足月胎膜早破产妇,分为观察组(30例)和对照组(34例),分别采用控释地诺前列酮栓和小剂量缩宫素引产。结果观察组治疗后4 h,12 h Bishop评分上升幅度高于同时点对照组(P<0.05),平均临产时间明显短于对照组(t=2.43,P<0.05),阴道分娩率明显高于对照组(χ2=5.59,P<0.05)。两组产后出血量和新生儿窒息率比较,无明显统计学差异(t=0.29,χ2=0.40,P>0.05)。观察组有2例发生宫缩过度刺激,取出普贝生后缓解;对照组出现1例恶心呕吐,症状较轻,未予处理,自行缓解。两组均无严重药物不良反应。结论控释地诺前列酮栓用于足月胎膜早破引产的疗效明显优于传统缩宫素,且临产时间短,降低了剖宫产率,安全性较好。此外,正确掌握使用方法,严密观察产程,加强护理,是取得良好引产效果的重要措施。展开更多
Objective:To explore the influence of acupuncture duration on the effect of acupuncute for patients with knee osteoarthritis(KOA).Methods:This secondary analysis was conducted based on the data of a randomized control...Objective:To explore the influence of acupuncture duration on the effect of acupuncute for patients with knee osteoarthritis(KOA).Methods:This secondary analysis was conducted based on the data of a randomized controlled trial about acupuncture on KOA.A total of 480 patients were recruited at nine centers.Only data from the manual acupuncture(MA)group and electroacupuncture(EA)group were included in this secondary analysis.The needles were retained for 30-min each time and treatment was given three times a week for 8 weeks.The follow-up visit lasted until week 26.Outcomes were numerical rating scale(NRS)on pain,Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)function and the response rate.Results:The NRS and WOMAC function at week 8 were lower than those at week 4(P<0.05),and were no significant difference compared with those at week 26 in MA and EA groups(P>0.05).Greater changes were observed in NRS and WOMAC function during 0-4 weeks compared with those during 4-8 weeks(P<0.05)in both groups.The response rate at week 8 was higher than it at week 4(P<0.05),and was no significant difference compared with it at week 26(P>0.05)in both groups.Association was found between BMI and changes of NRS(P<0.05),but not between BMI and WOMAC function(P>0.05)in MA group,while no asscoaition was found between BMI and NRS or WOMAC function in EA group(P>0.05).There was no association found between other factors and NRS or WOMAC function in both groups(P>0.05).Conclusion:For KOA patients,8-week acupuncture was more effective than 4-week acupuncture in relieving pain and improving joint function,but growth rate of the effect slowed down with increasing duration of intervention.It was uncertain whether the long-term effect of 8-week acupuncture was better than that of 4-week acupuncture.Further studies are required to further determine the effect of duration of intervention.展开更多
文摘目的观察控释地诺前列酮栓与缩宫素应用于足月胎膜早破引产的疗效及护理比较。方法选择64例足月胎膜早破产妇,分为观察组(30例)和对照组(34例),分别采用控释地诺前列酮栓和小剂量缩宫素引产。结果观察组治疗后4 h,12 h Bishop评分上升幅度高于同时点对照组(P<0.05),平均临产时间明显短于对照组(t=2.43,P<0.05),阴道分娩率明显高于对照组(χ2=5.59,P<0.05)。两组产后出血量和新生儿窒息率比较,无明显统计学差异(t=0.29,χ2=0.40,P>0.05)。观察组有2例发生宫缩过度刺激,取出普贝生后缓解;对照组出现1例恶心呕吐,症状较轻,未予处理,自行缓解。两组均无严重药物不良反应。结论控释地诺前列酮栓用于足月胎膜早破引产的疗效明显优于传统缩宫素,且临产时间短,降低了剖宫产率,安全性较好。此外,正确掌握使用方法,严密观察产程,加强护理,是取得良好引产效果的重要措施。
基金Supported by the Fundamental Research Funds for the Central Universities:2022-JYB-XJSJJ-030Beijing Municipal Science and Technology Commission:D171100003217003。
文摘Objective:To explore the influence of acupuncture duration on the effect of acupuncute for patients with knee osteoarthritis(KOA).Methods:This secondary analysis was conducted based on the data of a randomized controlled trial about acupuncture on KOA.A total of 480 patients were recruited at nine centers.Only data from the manual acupuncture(MA)group and electroacupuncture(EA)group were included in this secondary analysis.The needles were retained for 30-min each time and treatment was given three times a week for 8 weeks.The follow-up visit lasted until week 26.Outcomes were numerical rating scale(NRS)on pain,Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)function and the response rate.Results:The NRS and WOMAC function at week 8 were lower than those at week 4(P<0.05),and were no significant difference compared with those at week 26 in MA and EA groups(P>0.05).Greater changes were observed in NRS and WOMAC function during 0-4 weeks compared with those during 4-8 weeks(P<0.05)in both groups.The response rate at week 8 was higher than it at week 4(P<0.05),and was no significant difference compared with it at week 26(P>0.05)in both groups.Association was found between BMI and changes of NRS(P<0.05),but not between BMI and WOMAC function(P>0.05)in MA group,while no asscoaition was found between BMI and NRS or WOMAC function in EA group(P>0.05).There was no association found between other factors and NRS or WOMAC function in both groups(P>0.05).Conclusion:For KOA patients,8-week acupuncture was more effective than 4-week acupuncture in relieving pain and improving joint function,but growth rate of the effect slowed down with increasing duration of intervention.It was uncertain whether the long-term effect of 8-week acupuncture was better than that of 4-week acupuncture.Further studies are required to further determine the effect of duration of intervention.
