Many studies point out that weather conditions involving temperature, wind power, monsoon transform, air pressure, sea condition, tide, ocean current, salinity, eutrophic environment and so on are key factors causing ...Many studies point out that weather conditions involving temperature, wind power, monsoon transform, air pressure, sea condition, tide, ocean current, salinity, eutrophic environment and so on are key factors causing Red Tide. In the red tide high frequency areas of the South China Sea, the eutrophic environment of sea water has already existed, so the key elements such as meteorological and hydrological conditions play an importance role in the occurrence of red tide. The atmospheric circulation maintenance and variation decide whether meteorological phenomena, and hydrological key elements stabilize or change. Moreover, the red tide organisms＇ breeding from the initial stage to the blooming reproduction stage, until reaching the biological density of the red tide, generally takes 4 - 5 days. In the paper, the red tide examples are analyzed in the past 10 years, and the weather circulation situation and hydro-meteorological key elements of it are counted to find the previous circulation mode and bring out important factors inducing the blooming of red tide. The predicted result in 2003 according to this method was satisfactory.展开更多
目的探讨右美托咪定对失血性休克大鼠肺组织核因子κB(NF-κB)和炎症因子水平的影响及减轻急性肺损伤(ALI)的作用。方法将72只SD大鼠采用随机数字表法分为对照组(Con组,假手术)、ALI模型组(ALI组)、小剂量右美托咪定组(Dex-0.5组,0.5μg...目的探讨右美托咪定对失血性休克大鼠肺组织核因子κB(NF-κB)和炎症因子水平的影响及减轻急性肺损伤(ALI)的作用。方法将72只SD大鼠采用随机数字表法分为对照组(Con组,假手术)、ALI模型组(ALI组)、小剂量右美托咪定组(Dex-0.5组,0.5μg/kg)、中剂量右美托咪定组(Dex-1.5组,1.5μg/kg)、大剂量右美托咪定组(Dex-4.5组,4.5μg/kg)和NF-κB特异性抑制剂组(PDTC组),每组12只。经股动脉放血和股静脉回输血液,维持平均动脉压在35~45 mm Hg水平1 h,建立失血性休克ALI大鼠模型。建模后6 h采集股动脉血进行血气分析,计算氧合指数;处死大鼠取右肺组织测量湿/干重比(W/D),光镜观察并进行肺组织损伤评分,采用免疫组织化学法观察肺组织NF-κB表达水平;取左肺支气管肺泡灌洗液采用酶联免疫吸附试验检测白细胞介素(IL)-6、IL-10和肿瘤坏死因子-α(TNF)-α水平。结果与Con组比较,ALI组、Dex-0.5组大鼠W/D、肺组织损伤评分均升高,ALI组大鼠NF-κB、IL-6、IL-10、TNF-α水平均升高,差异均有统计学意义(P<0.05)。与ALI组比较,Dex-1.5组、Dex-4.5组、PDTC组大鼠W/D、肺组织损伤评分均降低,Dex-1.5组、Dex-4.5组大鼠NF-κB、IL-6、IL-10、TNF-α水平均降低,差异均有统计学意义(P<0.05)。与PDTC组比较,Dex-0.5组大鼠W/D升高,Dex-1.5组、Dex-4.5组大鼠NF-κB、IL-10、TNF-α水平均升高,差异均有统计学意义(P<0.05)。结论中、大剂量右美托咪定预处理可能通过抑制NF-κB活化及炎症因子表达减轻失血性休克大鼠ALI。展开更多
文摘Many studies point out that weather conditions involving temperature, wind power, monsoon transform, air pressure, sea condition, tide, ocean current, salinity, eutrophic environment and so on are key factors causing Red Tide. In the red tide high frequency areas of the South China Sea, the eutrophic environment of sea water has already existed, so the key elements such as meteorological and hydrological conditions play an importance role in the occurrence of red tide. The atmospheric circulation maintenance and variation decide whether meteorological phenomena, and hydrological key elements stabilize or change. Moreover, the red tide organisms＇ breeding from the initial stage to the blooming reproduction stage, until reaching the biological density of the red tide, generally takes 4 - 5 days. In the paper, the red tide examples are analyzed in the past 10 years, and the weather circulation situation and hydro-meteorological key elements of it are counted to find the previous circulation mode and bring out important factors inducing the blooming of red tide. The predicted result in 2003 according to this method was satisfactory.
文摘目的探讨右美托咪定对失血性休克大鼠肺组织核因子κB(NF-κB)和炎症因子水平的影响及减轻急性肺损伤(ALI)的作用。方法将72只SD大鼠采用随机数字表法分为对照组(Con组,假手术)、ALI模型组(ALI组)、小剂量右美托咪定组(Dex-0.5组,0.5μg/kg)、中剂量右美托咪定组(Dex-1.5组,1.5μg/kg)、大剂量右美托咪定组(Dex-4.5组,4.5μg/kg)和NF-κB特异性抑制剂组(PDTC组),每组12只。经股动脉放血和股静脉回输血液,维持平均动脉压在35~45 mm Hg水平1 h,建立失血性休克ALI大鼠模型。建模后6 h采集股动脉血进行血气分析,计算氧合指数;处死大鼠取右肺组织测量湿/干重比(W/D),光镜观察并进行肺组织损伤评分,采用免疫组织化学法观察肺组织NF-κB表达水平;取左肺支气管肺泡灌洗液采用酶联免疫吸附试验检测白细胞介素(IL)-6、IL-10和肿瘤坏死因子-α(TNF)-α水平。结果与Con组比较,ALI组、Dex-0.5组大鼠W/D、肺组织损伤评分均升高,ALI组大鼠NF-κB、IL-6、IL-10、TNF-α水平均升高,差异均有统计学意义(P<0.05)。与ALI组比较,Dex-1.5组、Dex-4.5组、PDTC组大鼠W/D、肺组织损伤评分均降低,Dex-1.5组、Dex-4.5组大鼠NF-κB、IL-6、IL-10、TNF-α水平均降低,差异均有统计学意义(P<0.05)。与PDTC组比较,Dex-0.5组大鼠W/D升高,Dex-1.5组、Dex-4.5组大鼠NF-κB、IL-10、TNF-α水平均升高,差异均有统计学意义(P<0.05)。结论中、大剂量右美托咪定预处理可能通过抑制NF-κB活化及炎症因子表达减轻失血性休克大鼠ALI。
