Drug delivery systems(DDSs) have been getting more and more attention in the field of cancer therapy with the development of nanotechnology. But remote and noninvasive controlled drug release for improving treatment e...Drug delivery systems(DDSs) have been getting more and more attention in the field of cancer therapy with the development of nanotechnology. But remote and noninvasive controlled drug release for improving treatment efficacy and reducing side effects faces great challenge. We report a kind of 'smart' nanocomposites(NCs) that is sensitive to the surrounding temperature by grafting a layer of thermosensitive polymer, poly(N-isopropylacrylamide)(pNIPAm),on the surface of single Cu_7S_4 nanoparticle(NP) via atomtransfer radical polymerization(ATRP). These NCs demonstrate a photothermal conversion efficiency of 25.4% under808-nmnear infrared(NIR) light irradiation and a drug loading content of 19.4%(drug/total NCs, w/w) with a lower critical solution temperature(LCST) of ~38°C. At normal physiological temperature(37°C), only 10.8% of the loaded doxorubicin(DOX) was released at physiological pH value(pH7.4) within 10 h. In the presence of 808-nm irradiation, due to the temperature increment as a result of photothermal effects,DOX was rapidly released.展开更多
The doping of radiocontrast agent such as bismuth（Bi） in copper chalcogenide nanocrystals for computed tomography（CT） imaging guided photothermal therapy（PTT） has drawn increasing attention. However, the doping ...The doping of radiocontrast agent such as bismuth（Bi） in copper chalcogenide nanocrystals for computed tomography（CT） imaging guided photothermal therapy（PTT） has drawn increasing attention. However, the doping of Bi often suffers from the weak CT signal due to the low Bi doping concentration and deteriorates the PTT efficacy of copper chalcogenides. Here we report a multifunctional nanoprobe by encapsulating both Cu_（1.94） S and Bi_2S_3 nanocrystals into a biocompatible poly（amino acid） matrix with size of^85 nm for CT imaging guided PTT. The amount of nanocrystals and the ratio of Cu1.94S-to-Bi2S3 in the multifunctional nanocomposites（NCs） are tunable toward both high photothermal conversion efficiency（~31%） and excellent CT imaging capability（27.8 HU g L^（-1））. These NCs demonstrate excellent effects for photothermal ablation of tumors after intratumoral injection on 4T1 tumor-bearing mice. Our study may provide a facile strategy for the fabrication of multifunctional theranostics towards simultaneous strong CT signal and excellent PTT.展开更多
基金supported by the National Natural Science Foundation of China(21475007,21275015 and 21505003)the Fundamental Research Funds for the Central Universities(YS1406,buctrc201507 and buctrc201608)+1 种基金the“Innovation and Promotion Project of Beijing University of Chemical Technology”,the“Public Hatching Platform for Recruited Talents of Beijing University of Chemical Technology,the High-Level Faculty Program of Beijing University of Chemical Technology(buctrc201325)BUCT Fund for Disciplines Construction and Development(XK1526)
文摘Drug delivery systems(DDSs) have been getting more and more attention in the field of cancer therapy with the development of nanotechnology. But remote and noninvasive controlled drug release for improving treatment efficacy and reducing side effects faces great challenge. We report a kind of 'smart' nanocomposites(NCs) that is sensitive to the surrounding temperature by grafting a layer of thermosensitive polymer, poly(N-isopropylacrylamide)(pNIPAm),on the surface of single Cu_7S_4 nanoparticle(NP) via atomtransfer radical polymerization(ATRP). These NCs demonstrate a photothermal conversion efficiency of 25.4% under808-nmnear infrared(NIR) light irradiation and a drug loading content of 19.4%(drug/total NCs, w/w) with a lower critical solution temperature(LCST) of ~38°C. At normal physiological temperature(37°C), only 10.8% of the loaded doxorubicin(DOX) was released at physiological pH value(pH7.4) within 10 h. In the presence of 808-nm irradiation, due to the temperature increment as a result of photothermal effects,DOX was rapidly released.
基金upported in part by the National Natural Science Foundation of China(21475007 and 21675009)the Fundamental Research Funds for the Central Universities(buctrc201608 and buctrc201720)
文摘The doping of radiocontrast agent such as bismuth（Bi） in copper chalcogenide nanocrystals for computed tomography（CT） imaging guided photothermal therapy（PTT） has drawn increasing attention. However, the doping of Bi often suffers from the weak CT signal due to the low Bi doping concentration and deteriorates the PTT efficacy of copper chalcogenides. Here we report a multifunctional nanoprobe by encapsulating both Cu_（1.94） S and Bi_2S_3 nanocrystals into a biocompatible poly（amino acid） matrix with size of^85 nm for CT imaging guided PTT. The amount of nanocrystals and the ratio of Cu1.94S-to-Bi2S3 in the multifunctional nanocomposites（NCs） are tunable toward both high photothermal conversion efficiency（~31%） and excellent CT imaging capability（27.8 HU g L^（-1））. These NCs demonstrate excellent effects for photothermal ablation of tumors after intratumoral injection on 4T1 tumor-bearing mice. Our study may provide a facile strategy for the fabrication of multifunctional theranostics towards simultaneous strong CT signal and excellent PTT.
