The dynamic kinetic resolution of 2-aroyl-l-tetralones was achieved via asymmetric transfer hydrogenation using (S,S)-RuCl(p-cymene)TsDPEN (TsDPEN=N-(tosyl)-1,2-diphenylethylenediamine) in formic acid/triethyl...The dynamic kinetic resolution of 2-aroyl-l-tetralones was achieved via asymmetric transfer hydrogenation using (S,S)-RuCl(p-cymene)TsDPEN (TsDPEN=N-(tosyl)-1,2-diphenylethylenediamine) in formic acid/triethylamine (5 : 2, molar ratio), afforded the desired products in good yields (up to 85%) with diastereomeric ratio up to 〉99 : 1 and high enantiomeric excesses (up to 〉99%). The absolute configuration of major the product was con- firmed by X-ray crystal structure analysis.展开更多
文摘The dynamic kinetic resolution of 2-aroyl-l-tetralones was achieved via asymmetric transfer hydrogenation using (S,S)-RuCl(p-cymene)TsDPEN (TsDPEN=N-(tosyl)-1,2-diphenylethylenediamine) in formic acid/triethylamine (5 : 2, molar ratio), afforded the desired products in good yields (up to 85%) with diastereomeric ratio up to 〉99 : 1 and high enantiomeric excesses (up to 〉99%). The absolute configuration of major the product was con- firmed by X-ray crystal structure analysis.