目的探讨维生素E干预治疗对脑梗死患者尿液中8-异前列腺素F_(2α)(8-iso-PGF_(2α))含量的影响。方法选取14例脑梗死患者作为治疗组,给予维生素E(300mg/d)治疗;另选取14例年龄、性别、血压、血脂、病灶部位及脑梗死程度与治疗组无显著...目的探讨维生素E干预治疗对脑梗死患者尿液中8-异前列腺素F_(2α)(8-iso-PGF_(2α))含量的影响。方法选取14例脑梗死患者作为治疗组,给予维生素E(300mg/d)治疗;另选取14例年龄、性别、血压、血脂、病灶部位及脑梗死程度与治疗组无显著差异的脑梗死患者作为对照组,不给予维生素E治疗。收集所有患者发病24h内和发病14天时的尿样和血清,测定尿样中8-iso-PGF_(2α)及血清中维生素E浓度。结果治疗组患者14天时尿液中8-iso-PGF_(2α)的浓度均显著低于对照组(85.20±9.17 vs 91.36±4.24ng/ mmol creatinine,P<0.05);而血清中维生素E的浓度显著高于对照组(15.56±6.98 vs 10.91±4.36μmol/L,P<0.05)。静脉血中低密度脂蛋白(LDL)中的总胆固醇、LDL三酰甘油和LDL游离胆固醇在治疗组与对照组间无显著性差异(分别为5.08±0.61 vs 4.72±0.61mmol/L,0.88±0.06 vs 0.84±0.03 mmol/L,1.72±0.41 vs 1.75±0.92mmol/L,P>0.05)。结论维生素E干预治疗可以降低急性期脑梗死患者尿液中8-iso-PGF_(2α)含量,减轻其体内的氧化压力。展开更多
It is well known that lipid peroxide in low density lipoprotein (LDL) plays an important role in atherosclerosis and atherosclerotic diseases. We used oxidized LDL generated by incu-bating LDL from healthy persons wit...It is well known that lipid peroxide in low density lipoprotein (LDL) plays an important role in atherosclerosis and atherosclerotic diseases. We used oxidized LDL generated by incu-bating LDL from healthy persons with copper dichloride as a model to investigate the anti-lipid-peroxide property of Radix Salviae Miltiorrhizae Composita (RSMC) and ligustrazine. The changes in concentrations of lipid peroxide and lipids in LDL due to Cu++ were studied, and the effects of RSMC and ligustrazine on the changes were studied. The re-sults in our study indicate that RSMC has a potential role on and-lipid-peroxidation, but it was not found that ligustrazine has similar anti-peroxidation action.展开更多
It is well known that plasma lipoprotein, particularly oxidized LDL, plays an important rolein the pathogenesis of atherosclerosis and atherosclerotic diseases. We used oxidized LDLgenerated by incubating LDL from hea...It is well known that plasma lipoprotein, particularly oxidized LDL, plays an important rolein the pathogenesis of atherosclerosis and atherosclerotic diseases. We used oxidized LDLgenerated by incubating LDL from healthy Persons with copper dichloride as a model to in-vestigate the antioxidate property of Radix Salviae Miltiorrhizae Composita (RSMC). Onphotos, the spot X1 and the spot X2 were clearly found in the control group after the dislysisinto copper dichloride for 24 and 48 hours, but they could not found in the RSMC group.The analysis of the constituents of lipids in LDL (by charring method) showed that afterdislysis the percentages of the spot X1 and the spot X2 in the RSMC group weresignificantly lower tban those in the control group (P【 0.01). The results suggest thatRSMC plays a potential role in antioxidation of lipuls or LDL.展开更多
目的探讨维生素E治疗对脑梗死患者血液中低密度脂蛋白体外氧化延迟时间的影响。方法选取22例脑梗死患者作为治疗组，给予维生素E（300mg／d）治疗；选取22例年龄、性别、血压、病灶部位及程度与治疗组相当的脑梗死患者作为对照组，不给...目的探讨维生素E治疗对脑梗死患者血液中低密度脂蛋白体外氧化延迟时间的影响。方法选取22例脑梗死患者作为治疗组，给予维生素E（300mg／d）治疗；选取22例年龄、性别、血压、病灶部位及程度与治疗组相当的脑梗死患者作为对照组，不给予维生素E治疗。收集患者发病24h以内和发病2周时血清，测定血样中低密度脂蛋白体外氧化延迟时间，同时测定血清中维生素E浓度，低密度脂蛋白中的总胆固醇、三酰甘油、游离胆固醇。结果治疗组患者2周时血样中低密度脂蛋白体外氧化延迟时间明显长于对照组[（71．84±9．75）min vs （60．95±9．33）min]，差异有统计学意义（P〈0．05）。血清中维生素E的浓度明显高于对照组[（17．41±5．24）μmol／LVS（12．90±6．27）μmol／L1，差异有统计学意义（P〈0．05），且与卒中症候呈现负相关趋势。治疗组与对照组静脉血巾低密度脂蛋白中的总胆固醇、三酰甘油、游离胆固醇差异无统计学意义[分别为（5．08±0．61）vs（4．72±0．61）mmol／L；（0．88±0．06）mmol/L vs（0．84±0．03）mmol／L；（1．62±0．41）vs（1．65±0．92）mmol／L1。结论给予维生素E治疗可以增加急性期脑梗死患者血液中低密度脂蛋白体外氧化延迟时间．增强患者体内的抗氧化能力。展开更多
文摘目的探讨维生素E干预治疗对脑梗死患者尿液中8-异前列腺素F_(2α)(8-iso-PGF_(2α))含量的影响。方法选取14例脑梗死患者作为治疗组,给予维生素E(300mg/d)治疗;另选取14例年龄、性别、血压、血脂、病灶部位及脑梗死程度与治疗组无显著差异的脑梗死患者作为对照组,不给予维生素E治疗。收集所有患者发病24h内和发病14天时的尿样和血清,测定尿样中8-iso-PGF_(2α)及血清中维生素E浓度。结果治疗组患者14天时尿液中8-iso-PGF_(2α)的浓度均显著低于对照组(85.20±9.17 vs 91.36±4.24ng/ mmol creatinine,P<0.05);而血清中维生素E的浓度显著高于对照组(15.56±6.98 vs 10.91±4.36μmol/L,P<0.05)。静脉血中低密度脂蛋白(LDL)中的总胆固醇、LDL三酰甘油和LDL游离胆固醇在治疗组与对照组间无显著性差异(分别为5.08±0.61 vs 4.72±0.61mmol/L,0.88±0.06 vs 0.84±0.03 mmol/L,1.72±0.41 vs 1.75±0.92mmol/L,P>0.05)。结论维生素E干预治疗可以降低急性期脑梗死患者尿液中8-iso-PGF_(2α)含量,减轻其体内的氧化压力。
文摘It is well known that lipid peroxide in low density lipoprotein (LDL) plays an important role in atherosclerosis and atherosclerotic diseases. We used oxidized LDL generated by incu-bating LDL from healthy persons with copper dichloride as a model to investigate the anti-lipid-peroxide property of Radix Salviae Miltiorrhizae Composita (RSMC) and ligustrazine. The changes in concentrations of lipid peroxide and lipids in LDL due to Cu++ were studied, and the effects of RSMC and ligustrazine on the changes were studied. The re-sults in our study indicate that RSMC has a potential role on and-lipid-peroxidation, but it was not found that ligustrazine has similar anti-peroxidation action.
文摘It is well known that plasma lipoprotein, particularly oxidized LDL, plays an important rolein the pathogenesis of atherosclerosis and atherosclerotic diseases. We used oxidized LDLgenerated by incubating LDL from healthy Persons with copper dichloride as a model to in-vestigate the antioxidate property of Radix Salviae Miltiorrhizae Composita (RSMC). Onphotos, the spot X1 and the spot X2 were clearly found in the control group after the dislysisinto copper dichloride for 24 and 48 hours, but they could not found in the RSMC group.The analysis of the constituents of lipids in LDL (by charring method) showed that afterdislysis the percentages of the spot X1 and the spot X2 in the RSMC group weresignificantly lower tban those in the control group (P【 0.01). The results suggest thatRSMC plays a potential role in antioxidation of lipuls or LDL.
文摘目的探讨维生素E治疗对脑梗死患者血液中低密度脂蛋白体外氧化延迟时间的影响。方法选取22例脑梗死患者作为治疗组，给予维生素E（300mg／d）治疗；选取22例年龄、性别、血压、病灶部位及程度与治疗组相当的脑梗死患者作为对照组，不给予维生素E治疗。收集患者发病24h以内和发病2周时血清，测定血样中低密度脂蛋白体外氧化延迟时间，同时测定血清中维生素E浓度，低密度脂蛋白中的总胆固醇、三酰甘油、游离胆固醇。结果治疗组患者2周时血样中低密度脂蛋白体外氧化延迟时间明显长于对照组[（71．84±9．75）min vs （60．95±9．33）min]，差异有统计学意义（P〈0．05）。血清中维生素E的浓度明显高于对照组[（17．41±5．24）μmol／LVS（12．90±6．27）μmol／L1，差异有统计学意义（P〈0．05），且与卒中症候呈现负相关趋势。治疗组与对照组静脉血巾低密度脂蛋白中的总胆固醇、三酰甘油、游离胆固醇差异无统计学意义[分别为（5．08±0．61）vs（4．72±0．61）mmol／L；（0．88±0．06）mmol/L vs（0．84±0．03）mmol／L；（1．62±0．41）vs（1．65±0．92）mmol／L1。结论给予维生素E治疗可以增加急性期脑梗死患者血液中低密度脂蛋白体外氧化延迟时间．增强患者体内的抗氧化能力。
