目的:探讨3.0T磁共振扩散峰度成像(DKI)及弥散加权成像(DWI)在宫颈癌(CC)不同病理组织学类型诊断中的应用价值。方法:回顾性分析2019年10月—2020年11月在我院放射科经病理结果证实的宫颈癌患者42例。所有患者均行MR常规、DWI及DKI序列...目的:探讨3.0T磁共振扩散峰度成像(DKI)及弥散加权成像(DWI)在宫颈癌(CC)不同病理组织学类型诊断中的应用价值。方法:回顾性分析2019年10月—2020年11月在我院放射科经病理结果证实的宫颈癌患者42例。所有患者均行MR常规、DWI及DKI序列扫描,通过相应模型获得平均峰度(MK)值、平均扩散系数(MD)值、平均表观扩散系数(ADC)值及指数表观系数(eADC)值,观察各参数值与CC组织学类型的差别,存在统计学意义的参数行受试者工作特征(ROC)曲线评价其诊断效能。结果:宫颈鳞癌组的M D值、平均A D C值低于宫颈腺癌组,eADC值高于宫颈腺癌组,差异有统计学意义(P<0.05),ROC曲线下面积分别为0.698、0.691和0.704;MK值与CC组织学类型差异无统计学意义(P>0.05)。结论:3.0T磁共振DWI参数和D K I定量参数有助于反应宫颈癌的病理组织学特征,但与DWI相比,D K I未显示出明显的附加价值。展开更多
This study was to evaluate the efficacy and safety of early application of citicoline in the treatment of patients with acute stroke by meta-analysis. Randomized controlled trials published until May 2015 were electro...This study was to evaluate the efficacy and safety of early application of citicoline in the treatment of patients with acute stroke by meta-analysis. Randomized controlled trials published until May 2015 were electronically searched in MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, WHO International Clinical Trial Registration Platform, Clinical Trial.gov, and China Biology Medicine disc. Two reviewers independently screened the articles and extracted the data based on the inclusion and exclusion criteria. The quality of included articles was evaluated by using Revman5.0, and meta-analysis was performed. The results showed that 1027 articles were obtained in initial retrieval, and finally 7 articles, involving a total of 4039 cases, were included for analysis. The meta-analysis showed that no significant differences were found in the long-term mortality（OR=0.91, 95% CI 0.07 to 1.09, P=0.30）, the rate of dependency（OR=1.02, 95% CI 0.87 to 1.24, P=0.85）, and the effective rate（OR=0.98, 95% CI 0.84 to 1.14, P=0.82） between citicoline group and control group. The overall rate of adverse events in citicoline group was not significantly different from that in control group（P=0.30）. The quality of included articles reached moderate-low level. In conclusion, citicolne cannot reduce long-term mortality and dependence rate in the treatment of acute stroke, and the effective rate of citivoline may be not better than that of controls but with reliable safety.展开更多
文摘目的:探讨3.0T磁共振扩散峰度成像(DKI)及弥散加权成像(DWI)在宫颈癌(CC)不同病理组织学类型诊断中的应用价值。方法:回顾性分析2019年10月—2020年11月在我院放射科经病理结果证实的宫颈癌患者42例。所有患者均行MR常规、DWI及DKI序列扫描,通过相应模型获得平均峰度(MK)值、平均扩散系数(MD)值、平均表观扩散系数(ADC)值及指数表观系数(eADC)值,观察各参数值与CC组织学类型的差别,存在统计学意义的参数行受试者工作特征(ROC)曲线评价其诊断效能。结果:宫颈鳞癌组的M D值、平均A D C值低于宫颈腺癌组,eADC值高于宫颈腺癌组,差异有统计学意义(P<0.05),ROC曲线下面积分别为0.698、0.691和0.704;MK值与CC组织学类型差异无统计学意义(P>0.05)。结论:3.0T磁共振DWI参数和D K I定量参数有助于反应宫颈癌的病理组织学特征,但与DWI相比,D K I未显示出明显的附加价值。
文摘This study was to evaluate the efficacy and safety of early application of citicoline in the treatment of patients with acute stroke by meta-analysis. Randomized controlled trials published until May 2015 were electronically searched in MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, WHO International Clinical Trial Registration Platform, Clinical Trial.gov, and China Biology Medicine disc. Two reviewers independently screened the articles and extracted the data based on the inclusion and exclusion criteria. The quality of included articles was evaluated by using Revman5.0, and meta-analysis was performed. The results showed that 1027 articles were obtained in initial retrieval, and finally 7 articles, involving a total of 4039 cases, were included for analysis. The meta-analysis showed that no significant differences were found in the long-term mortality（OR=0.91, 95% CI 0.07 to 1.09, P=0.30）, the rate of dependency（OR=1.02, 95% CI 0.87 to 1.24, P=0.85）, and the effective rate（OR=0.98, 95% CI 0.84 to 1.14, P=0.82） between citicoline group and control group. The overall rate of adverse events in citicoline group was not significantly different from that in control group（P=0.30）. The quality of included articles reached moderate-low level. In conclusion, citicolne cannot reduce long-term mortality and dependence rate in the treatment of acute stroke, and the effective rate of citivoline may be not better than that of controls but with reliable safety.
