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掌叶覆盆子化学成分的研究 被引量:50
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作者 肖洪明 祖灵博 +2 位作者 李石平 王开金 李宁 《中国药物化学杂志》 CAS CSCD 2011年第3期220-226,共7页
目的研究蔷薇科悬钩子属掌叶覆盆子(Rubus chingii)干燥果实的化学成分。方法采用硅胶柱色谱、Sephadex LH-20、ODS和MCI柱色谱等手段进行化合物的分离与纯化,通过波谱分析,结合理化性质鉴定各化合物的结构。结果从覆盆子体积分数80%乙... 目的研究蔷薇科悬钩子属掌叶覆盆子(Rubus chingii)干燥果实的化学成分。方法采用硅胶柱色谱、Sephadex LH-20、ODS和MCI柱色谱等手段进行化合物的分离与纯化,通过波谱分析,结合理化性质鉴定各化合物的结构。结果从覆盆子体积分数80%乙醇提取物中分离得到18个已知化合物,分别鉴定为山柰酚(1)、紫云英苷(2)、山柰酚-3-O-β-D-吡喃葡萄糖醛酸甲酯(3)、山柰酚-3-O-芸香糖苷(4)、椴树苷(5)、异槲皮苷(6)、芦丁(7)、根皮苷(8)、β-谷甾醇(9)、β-胡萝卜苷(10)、乌苏酸(11)、2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid(12)、nigaichigoside F1(13)、覆盆子苷F5(14)、没食子酸(15)、短叶苏木酚酸甲酯(16)、葡萄糖(17)和甲基-β-D-吡喃葡萄糖苷(18)。结论化合物4、7、81、2、13、16和18均为首次从该植物中分离得到,其中化合物12为首次从该属植物中发现。 展开更多
关键词 覆盆子 悬钩子属 化学成分
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Antioxidant and Cytotoxic Diarylheptanoids Isolated from Zingiber officinale Rhizomes
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作者 李宁 汪玲玉 +3 位作者 祖灵博 王开金 邸磊 王志 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2012年第6期1351-1355,共5页
One new diarylheptanoid, namely (4E,6E)-7-(3,4-dihydroxy-5-methoxyphenyl)-1-(4-hydroxy-3-methoxyphenyl)- hepta-4,6-dien-3-one (1), was isolated from the rhizomes of Zingiber officinale, along with ten known on... One new diarylheptanoid, namely (4E,6E)-7-(3,4-dihydroxy-5-methoxyphenyl)-1-(4-hydroxy-3-methoxyphenyl)- hepta-4,6-dien-3-one (1), was isolated from the rhizomes of Zingiber officinale, along with ten known ones, tetra- hydrocurcumin (2), curcumin (3), 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)heptan-3-one (4), gingerenone A (5), 7-(3,4-dihydroxyphenyl)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)heptan-3-one (6), (E)-1,7-bis(4-hydroxy- 3-methoxyphenyl)hept-1-ene-3,5-dione (7), (E)-7-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)-hept-l-ene- 3,5-dione (8), shogasulfonic acid A (9), 1,5-epoxy-3-hydroxy-1-(3,4-dihydroxy-5-methoxyphenyl)-7-(4-hydroxy-3- methoxyphenyl)heptane (10), and (3S, SS)-3,5-diacetoxy-1,7-bis(3,4-dihydroxyphenyl)heptane (11). Their structures were elucidated on the basis of spectral evidence and comparisons with literature data. The free radical scavenging activity of 1--11 was evaluated by the 1,l-diphenyl-2-picrylhydrazyl (DPPH) assay. Most of the isolated com- pounds were found to be better antioxidants than the positive control ascorbic acid. These compounds were also evaluated for their cytotoxicity against HeLa and MNK-45 cells using the MTT assay. Our results suggest that com- pounds 3 and 5-8 inhibited HeLa cells, and 3, 5, 7 and 8 inhibited MNK-45 cells. It was found that compound 5 was markedly cytotoxic against HeLa and MNK-45 cell lines with ICs0 values of 6.4 and 7.8 μmol/L, respectively. 展开更多
关键词 Zingiber officinale DIARYLHEPTANOID NMR spectroscopy structure elucidation antioxidant and cyto-toxic activities
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