目的:了解我国中老年人抑郁和慢性病的关联。方法:利用我国健康与养老追踪调查(China health and retirement longitudinal study,CHARLS)2011年基线数据,纳入10420名45岁及以上的中老年人,收集研究对象的人口学资料、生活习惯和慢性病...目的:了解我国中老年人抑郁和慢性病的关联。方法:利用我国健康与养老追踪调查(China health and retirement longitudinal study,CHARLS)2011年基线数据,纳入10420名45岁及以上的中老年人,收集研究对象的人口学资料、生活习惯和慢性病患病情况。抑郁症状采用10条目的流调中心抑郁量表(10-item version of center for epidemiological studied depression,CESD-10)测量,CESD-10评分≥10定义为有抑郁症状。采用多因素Logistic回归模型分析抑郁症状和慢性病的关联。结果:纳入的10420名研究对象的平均年龄为(59.2±9.4)岁,48.2%为男性,其中3900名(37.4%)中老年人有抑郁症状。多因素Logistic回归分析结果显示,在调整所有潜在混杂因素以后,抑郁症状和糖尿病(OR=1.230,95%CI:1.080~1.401)、高血压(OR=1.335,95%CI:1.205~1.480)、心脏病(OR=1.953,95%CI:1.711~2.229)、脑卒中(OR=2.269,95%CI:1.704~3.020)均有关联(P<0.05),而未发现血脂异常和抑郁症状之间存在显著关联(P>0.05),随着共患慢性病数量的增加,抑郁症状的患病率也随之升高(P trend<0.001)。结论:我国中老年人抑郁症状和慢性病有关联,未来需要在前瞻性研究中进一步探究二者是否有因果关系。展开更多
CYP3A4 plays a critical role in clopidogrel activation in the liver.The polymorphism of CYP3A4 may have an important effect on clopidogrel response in patients with cardio-cerebrovascular diseases.We conducted a syste...CYP3A4 plays a critical role in clopidogrel activation in the liver.The polymorphism of CYP3A4 may have an important effect on clopidogrel response in patients with cardio-cerebrovascular diseases.We conducted a systematic review and meta-analysis to evaluate the impact of CYP3A4 polymorphism on platelet reactivity after clopidogrel treatment and the outcomes of patients.A systematic literature search(up to 7th October,2019)was performed on the PubMed,EMBASE,Cochrane Library,clinicaltrials.gov,and Chinese databases,including China National Knowledge Infrastructure(CNKI)and Wan Fang Data.Cohort studies or case-control studies evaluated platelet reactivity and patients‟outcomes in different genotype patients.The Review Manager software was used for data analysis,and the NOS scale was used to assess the quality of included studies.A total of 18 articles were included in the Meta-analysis.The results showed the platelet reactivity after clopidogrel administration had no significant difference between CYP3A4 variant carriers and non-carriers.The occurrence of composite ischemic events or stent thrombosis had no significant difference between CYP3A4 variant carriers and non-carriers,either.In conclusion,there was no significant association between CYP3A4 polymorphism and clopidogrel response in patients with cardio-cerebrovascular diseases.展开更多
文摘目的:了解我国中老年人抑郁和慢性病的关联。方法:利用我国健康与养老追踪调查(China health and retirement longitudinal study,CHARLS)2011年基线数据,纳入10420名45岁及以上的中老年人,收集研究对象的人口学资料、生活习惯和慢性病患病情况。抑郁症状采用10条目的流调中心抑郁量表(10-item version of center for epidemiological studied depression,CESD-10)测量,CESD-10评分≥10定义为有抑郁症状。采用多因素Logistic回归模型分析抑郁症状和慢性病的关联。结果:纳入的10420名研究对象的平均年龄为(59.2±9.4)岁,48.2%为男性,其中3900名(37.4%)中老年人有抑郁症状。多因素Logistic回归分析结果显示,在调整所有潜在混杂因素以后,抑郁症状和糖尿病(OR=1.230,95%CI:1.080~1.401)、高血压(OR=1.335,95%CI:1.205~1.480)、心脏病(OR=1.953,95%CI:1.711~2.229)、脑卒中(OR=2.269,95%CI:1.704~3.020)均有关联(P<0.05),而未发现血脂异常和抑郁症状之间存在显著关联(P>0.05),随着共患慢性病数量的增加,抑郁症状的患病率也随之升高(P trend<0.001)。结论:我国中老年人抑郁症状和慢性病有关联,未来需要在前瞻性研究中进一步探究二者是否有因果关系。
基金National Natural Science Foundation of China(Grant No.81803497)。
文摘CYP3A4 plays a critical role in clopidogrel activation in the liver.The polymorphism of CYP3A4 may have an important effect on clopidogrel response in patients with cardio-cerebrovascular diseases.We conducted a systematic review and meta-analysis to evaluate the impact of CYP3A4 polymorphism on platelet reactivity after clopidogrel treatment and the outcomes of patients.A systematic literature search(up to 7th October,2019)was performed on the PubMed,EMBASE,Cochrane Library,clinicaltrials.gov,and Chinese databases,including China National Knowledge Infrastructure(CNKI)and Wan Fang Data.Cohort studies or case-control studies evaluated platelet reactivity and patients‟outcomes in different genotype patients.The Review Manager software was used for data analysis,and the NOS scale was used to assess the quality of included studies.A total of 18 articles were included in the Meta-analysis.The results showed the platelet reactivity after clopidogrel administration had no significant difference between CYP3A4 variant carriers and non-carriers.The occurrence of composite ischemic events or stent thrombosis had no significant difference between CYP3A4 variant carriers and non-carriers,either.In conclusion,there was no significant association between CYP3A4 polymorphism and clopidogrel response in patients with cardio-cerebrovascular diseases.
