Objective:To analyze the relationship between karyotypes and clinic features of patients with primary amenorrhea. Method:G-banding was employed in karyotype analysis of patients with primary amenorrhea. Results:Karyot...Objective:To analyze the relationship between karyotypes and clinic features of patients with primary amenorrhea. Method:G-banding was employed in karyotype analysis of patients with primary amenorrhea. Results:Karyotype analysis of 468 patients with primary amenorrhea revealed that 255 patients(54.49%) had normal female karyotypes and 213 patients(45.41%) had abnormal karyotypes,including 143 patients with abnormal X chromosome,4 patients with mosaic X-Y chromosome,57 patients with 46,XY karyotype,8 patients with abnormal autosome and one patient with X-autosome translocation.All primary amenorrhea patients with deletion or break-up in Xp11.1-11.4 were short in stature. Conclusion:One of the main reasons of primary amenorrhea was chromosome abnormalities,especially sex chromosome abnormalities.Karyotype analysis should be routinely applied to detect primary amenorrhea patients. Xp11-12 may be critical to development of stature.展开更多
目的探讨生长激素（GH）宫腔灌注联合替代周期在薄型子宫内膜患者冻融胚胎移植中的临床疗效。方法回顾性分析2014年6月至2015年9月在湖南省妇幼保健院生殖中心行替代周期冻胚移植的患者共88个周期，其中激素替代周期组（A组）63个，GH...目的探讨生长激素（GH）宫腔灌注联合替代周期在薄型子宫内膜患者冻融胚胎移植中的临床疗效。方法回顾性分析2014年6月至2015年9月在湖南省妇幼保健院生殖中心行替代周期冻胚移植的患者共88个周期，其中激素替代周期组（A组）63个，GH宫腔灌注联合替代周期薄型子宫内膜组（B组）25个。比较分析两组患者子宫内膜厚度、临床妊娠及胚胎种植情况。结果B组25例患者既往移植日子宫内膜厚度〈7 mm，本周期应用GH灌注联合替代周期治疗后，22例患者移植日子宫内膜厚度≥7 mm。两组患者年龄、不孕年限、移植胚胎数及移植优胚数差异均无统计学意义（P〉0.05）。A组患者移植日子宫内膜厚度[（9.28±1.64）mm]明显高于B组子宫内膜厚度[（7.9±0.86）mm]，差异有统计学意义（P〈0.05）；但A组与B组临床妊娠率（50.79% vs 52.0%）、种植率（31.1% vs 47.17%）、流产率（9.38% vs 15.38%）与多胎妊娠率（25.0% vs 46.2%）差异无统计学意义（P〉0.05）。移植日子宫内膜〈8 mm时，A组患者临床妊娠率为30.76%，低于B组临床妊娠率54.54%，两者差异无统计学意义（P〉0.05）；但A组胚胎种植率明显低于B组（20% vs 52.17%），差异有统计学意义（P〈0.05）。子宫内膜厚度≥8.0 mm时，两组患者临床妊娠率（58.33% vs 63.63%）与种植率（36.36% vs 50%）差异无统计学意义（P〉0.05）。结论GH灌注联合替代周期有可能改善子宫内膜容受性，从而提高冻胚周期中薄型子宫内膜患者的临床妊娠与胚胎种植水平。展开更多
文摘Objective:To analyze the relationship between karyotypes and clinic features of patients with primary amenorrhea. Method:G-banding was employed in karyotype analysis of patients with primary amenorrhea. Results:Karyotype analysis of 468 patients with primary amenorrhea revealed that 255 patients(54.49%) had normal female karyotypes and 213 patients(45.41%) had abnormal karyotypes,including 143 patients with abnormal X chromosome,4 patients with mosaic X-Y chromosome,57 patients with 46,XY karyotype,8 patients with abnormal autosome and one patient with X-autosome translocation.All primary amenorrhea patients with deletion or break-up in Xp11.1-11.4 were short in stature. Conclusion:One of the main reasons of primary amenorrhea was chromosome abnormalities,especially sex chromosome abnormalities.Karyotype analysis should be routinely applied to detect primary amenorrhea patients. Xp11-12 may be critical to development of stature.
文摘目的探讨生长激素（GH）宫腔灌注联合替代周期在薄型子宫内膜患者冻融胚胎移植中的临床疗效。方法回顾性分析2014年6月至2015年9月在湖南省妇幼保健院生殖中心行替代周期冻胚移植的患者共88个周期，其中激素替代周期组（A组）63个，GH宫腔灌注联合替代周期薄型子宫内膜组（B组）25个。比较分析两组患者子宫内膜厚度、临床妊娠及胚胎种植情况。结果B组25例患者既往移植日子宫内膜厚度〈7 mm，本周期应用GH灌注联合替代周期治疗后，22例患者移植日子宫内膜厚度≥7 mm。两组患者年龄、不孕年限、移植胚胎数及移植优胚数差异均无统计学意义（P〉0.05）。A组患者移植日子宫内膜厚度[（9.28±1.64）mm]明显高于B组子宫内膜厚度[（7.9±0.86）mm]，差异有统计学意义（P〈0.05）；但A组与B组临床妊娠率（50.79% vs 52.0%）、种植率（31.1% vs 47.17%）、流产率（9.38% vs 15.38%）与多胎妊娠率（25.0% vs 46.2%）差异无统计学意义（P〉0.05）。移植日子宫内膜〈8 mm时，A组患者临床妊娠率为30.76%，低于B组临床妊娠率54.54%，两者差异无统计学意义（P〉0.05）；但A组胚胎种植率明显低于B组（20% vs 52.17%），差异有统计学意义（P〈0.05）。子宫内膜厚度≥8.0 mm时，两组患者临床妊娠率（58.33% vs 63.63%）与种植率（36.36% vs 50%）差异无统计学意义（P〉0.05）。结论GH灌注联合替代周期有可能改善子宫内膜容受性，从而提高冻胚周期中薄型子宫内膜患者的临床妊娠与胚胎种植水平。
