30%甲氨基阿维菌素苯甲酸盐水分散粒剂的配制

通过对润湿剂、分散剂、崩解剂、稳定剂和填料等的筛选,确定了30%甲氨基阿维菌素苯甲酸盐水分散粒剂的配方,并对制得样品的质量指标进行了测定。30%甲氨基阿维菌素苯甲酸盐水分散粒剂最佳配方为:34%甲氨基阿维菌素苯甲酸盐原药(90%)、5%分散剂聚羧酸盐HT-5050、5%扩散剂NNO、3%润湿剂Morwet EFW、5%崩解剂CMS、2%黏结剂麦芽糊精、3%稳定剂wgwin D902、5%钛白粉和38%填料硫酸钠。制得样品的各项指标符合水分散粒剂的要求。

90%乙酰甲胺磷可溶性粒剂的配制

以98%乙酰甲胺磷为原料,进行了90%乙酰甲胺磷可溶性粒剂的配方研究,并对样品的溶解性、稳定性进行测定,筛选出最佳配方。其最佳配方:98%乙酰甲胺磷92%,黏结剂P(有效成分为聚乙烯吡咯烷酮)4%,稳定剂N(有效成分为十二烷基聚氧乙烯醚磷酸酯胺盐)2%,渗透剂T(有效成分为磺化琥珀酸二辛酯钠盐)2%。

Synthesis and Crystal Structure of 2,5-Di-(pyridin-3-yl)-1,3,4-oxadiazolendium Nitrate

In order to continue our studies on the synthesis, properties and coordination of s-tetrazine, 3,6-di-（pyridin-3-yl）-s-tetrazine （Ⅱ, 3-dptz） was synthesized and characterized by ^1HNMR, MS and IR spectra. And the coordination reaction of 3-dptz with nitrate of Cu（Ⅱ） was studied. 3-dptz reacting with CuⅡ salt [Cu（NO3）2·2H2O] generates a new salt, nitrate of 2,5-di-（pyridin-3- yl）-1,3,4-oxadiazolene （Ⅲ）. Ⅲ was determined by IR spectra and single-crystal X-ray diffraction to give the following crystal data： space group P21/c, a = 4.9112（1）, b = 8.4101（3）, c = 29.499（1）（A）, β = 93.266（2）°, V = 1216.44（7） nm^3, Mr = 287.24, Z = 4, Dc = 1.568 g/cm^3,μ= 0.122 mm^-1, F（000） = 592, R = 0.0430 and wR = 0.1240. The results show that Ⅲ is composed of one cation and one nitrate anion. The cation consists of one H＋ and one 2,5-di-（pyridin-3-yl）-1,3,4-oxadiazol molecule, with the former being attached to the latter via electrovalent bond with N3 atom. And the O（42） atom in the nitrate anion is disordered. Intra- and intermolecular H-bonds are observed in the crystal of the title compound. The mechanism of metal-assisted decomposition was also discussed briefly.