一株红树内生真菌Penicillium sp.化学成分研究

综合运用各种色谱分离技术硅胶柱层析、Sephadex LH-20凝胶柱层析、高效液相色谱等,从一株来源于药用红树尖瓣海莲(Bruguiera sexangula var.rhynchopetala)的青霉属真菌Penicillium sp.(56211)的发酵产物中分离鉴定了5个化合物.根据理化性质、波谱方法,并与文献数据对照,确定结构分别为:[11]-cytochalasa-6(12),13-diene-1,21-dione-7,18-dihydroxy-16,18-dimethyl-10-phenyl-(7S*,13E,16S*,18R*)(1),[11]-Cytochalasa-6(12),13-diene-1,21-dione-7,18-dihydroxy-16,18-dimethyl-19-methoxy-l0-phenyl-(7S*,13E,16S*,18S*,19R*)(2),[11]-cytochalasa-6(12),13-diene-1,21-dione-7,18,19-trihydroxy-16,18-dimethyl-10-phenyl-(7S*,13E,16S*,18S*,19R*)(3),1-(2,6-dihydroxyphenyl)butan-1-one(4)和O-methylcurvulinic acid(5).所有化合物为首次从尖瓣海莲内生真菌中分离得到.