Kainic acid(KA),a prospective neuroexcitable and neurotoxic analog of glumate,inducespersistent seizure activity in limbic structures which results in behavioral symptoms,electrographic and neuropathologic alternation...Kainic acid(KA),a prospective neuroexcitable and neurotoxic analog of glumate,inducespersistent seizure activity in limbic structures which results in behavioral symptoms,electrographic and neuropathologic alternations closely resembling human temporal lobe epi-lepsy.The hippocampal pyramidal cells possess abundant KA high affinity binding sites intheir membranes and are extremely vulnerable to KA neurotoxicity.NT-3 is a memberof the neurotrophic family(NTF)including nerve growth factor(NGF),brain derivedneurotrophic factor(BDNF),neurotrophin-4/5(NF-4/5).NT-3 mRNA was expressed展开更多
基金Project supported by the National Natural Science Foundation of China.
文摘Kainic acid(KA),a prospective neuroexcitable and neurotoxic analog of glumate,inducespersistent seizure activity in limbic structures which results in behavioral symptoms,electrographic and neuropathologic alternations closely resembling human temporal lobe epi-lepsy.The hippocampal pyramidal cells possess abundant KA high affinity binding sites intheir membranes and are extremely vulnerable to KA neurotoxicity.NT-3 is a memberof the neurotrophic family(NTF)including nerve growth factor(NGF),brain derivedneurotrophic factor(BDNF),neurotrophin-4/5(NF-4/5).NT-3 mRNA was expressed
