Objective To investigate the distribution characteristics of some commo n and trace elements in both serum and lymphocyte in patients with essential hyp ertension and to analyse their possible role in the pathogenesis...Objective To investigate the distribution characteristics of some commo n and trace elements in both serum and lymphocyte in patients with essential hyp ertension and to analyse their possible role in the pathogenesis of hypertension . Methods A crosssectional study was carried out in 102 hypertensive pa tients ma tched with equal number of normotensive subjects by sex, age, and hypertensive f amily history; all of them were randomly selected from the same community. Both intralymphocytic and serum concentrations of some relevant elements including Na +, K+, Ca2+, Mg2+, Zn2+, Cu2+ and P were measured fo r all studied subjects, using the inductively coupled plasma spectrometry (ICPS) . Results 1. Both intralymphocytic and serum concentrations of Na+ ( P =0.009, 0.004 respectively), and Ca2+ ( P =0.001, 0.04 9 respectively) in hypertensive group were significantly higher than those in th e normotensives. 2. Stepwise regression analysis disclosed that systolic and dia stolic blood pressure had significant correlation with age, serum Na+/K+ rat io and intralymphocytic Ca2+, Mg2+ concentrations ( P <0.0 01 for both). 3. According to hypertensive family history, the method of multipl e variance analysis had been employed for 4 subgroups and the results revealed t hat the concentrations of serum Ca2+ and lymphocytic Na+ were significan tly higher in hypertensives with or without family history than in normotensives without family history. Furthermore, intralymphocytic Na+ concentration was significantly higher in normotensives with positive family history than that in normotensives without family history. Conclusion The serum and intralymphocytic distribution characteristics of elements in hypertensive patients compared with normotensive controls suggest ed that there might exist certain defects of the iontransporting system on cel l membrane which might be genetically linked.展开更多
文摘Objective To investigate the distribution characteristics of some commo n and trace elements in both serum and lymphocyte in patients with essential hyp ertension and to analyse their possible role in the pathogenesis of hypertension . Methods A crosssectional study was carried out in 102 hypertensive pa tients ma tched with equal number of normotensive subjects by sex, age, and hypertensive f amily history; all of them were randomly selected from the same community. Both intralymphocytic and serum concentrations of some relevant elements including Na +, K+, Ca2+, Mg2+, Zn2+, Cu2+ and P were measured fo r all studied subjects, using the inductively coupled plasma spectrometry (ICPS) . Results 1. Both intralymphocytic and serum concentrations of Na+ ( P =0.009, 0.004 respectively), and Ca2+ ( P =0.001, 0.04 9 respectively) in hypertensive group were significantly higher than those in th e normotensives. 2. Stepwise regression analysis disclosed that systolic and dia stolic blood pressure had significant correlation with age, serum Na+/K+ rat io and intralymphocytic Ca2+, Mg2+ concentrations ( P <0.0 01 for both). 3. According to hypertensive family history, the method of multipl e variance analysis had been employed for 4 subgroups and the results revealed t hat the concentrations of serum Ca2+ and lymphocytic Na+ were significan tly higher in hypertensives with or without family history than in normotensives without family history. Furthermore, intralymphocytic Na+ concentration was significantly higher in normotensives with positive family history than that in normotensives without family history. Conclusion The serum and intralymphocytic distribution characteristics of elements in hypertensive patients compared with normotensive controls suggest ed that there might exist certain defects of the iontransporting system on cel l membrane which might be genetically linked.
