A Ru-arene compound containing two thiosemicarbazone ligands [(η6-p-cymene)Ru(TSC)2 Cl]Cl(1, TSC = benzophenone 4-methylthiosemicarbazone) has been synthesized and characterized by 1 H NMR, elemental analysis and HR-...A Ru-arene compound containing two thiosemicarbazone ligands [(η6-p-cymene)Ru(TSC)2 Cl]Cl(1, TSC = benzophenone 4-methylthiosemicarbazone) has been synthesized and characterized by 1 H NMR, elemental analysis and HR-ESI mass spectrometry analysis. The molecular structure was determined by single-crystal X-ray diffraction analysis. The in vitro anticancer activities of the complex have been evaluated against two human cancer cell lines(SGC-7901, BEL-7404), and the IC50 values are 32.5 and 57 μM, respectively.展开更多
基金Supported by the National Natural Science Foundation of China(21761006)Guangxi Natural Science Foundation(2016GXNSFCA380013,2017GXNSFAA198335,2018GXNSFAA281345)+3 种基金Guangxi Scientific and Technological Development Projects(AD17195081),“BAGUI Scholar” Program of Guangxi Province of China,Guangxi Key Laboratory of Natural Polymer Chemistry and Physics and Nanning Normal University,Natural Science Foundation of Guangxi University of Chinese Medicine(2017JQ001)Natural Science Foundation of Team of Professor Shilin Yang(YSL17004)the specific subject of the dominant discipline construction of Chinese pharmacy from Guangxi University of Chinese Medicine(ZYX2017003)Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine,Collaborative Innovation Center of Zhuang and Yao Ethnic Medicine,Guangxi Key Discipline(Zhuang Pharmacology)
文摘A Ru-arene compound containing two thiosemicarbazone ligands [(η6-p-cymene)Ru(TSC)2 Cl]Cl(1, TSC = benzophenone 4-methylthiosemicarbazone) has been synthesized and characterized by 1 H NMR, elemental analysis and HR-ESI mass spectrometry analysis. The molecular structure was determined by single-crystal X-ray diffraction analysis. The in vitro anticancer activities of the complex have been evaluated against two human cancer cell lines(SGC-7901, BEL-7404), and the IC50 values are 32.5 and 57 μM, respectively.
