抑瘤素M在炎症性疾病中的研究进展

抑瘤素M(OSM)是一种属于IL-6家族的多功能细胞因子,它主要由免疫细胞产生,参与了肿瘤、炎症、造血、骨骼组织改变、肝脏再生以及神经系统、心血管和代谢疾病等多种重要的生理及病理过程。OSM在炎症性疾病中发挥了重要作用。OSM生物学活性既有促炎作用,又有抑炎作用,但在不同的疾病以及同一疾病不同时间可能表现出不同的生物学功能。文章就OSM在炎症性疾病中的作用作综述。

旅游参与城市更新的理论与实践思考——以嘉兴乌镇的城市更新为例

旅游产业为城市发展提供基础,促进消费的增长,促进旅游地的城市更新,而城市的发展亦会反哺于旅游业,两者互为背景,相互影响,相互作用。嘉兴乌镇在1999年时以保护与开发为目的进行城市更新,带动了当地旅游业的发展繁荣,成为世界互联网大会会址,进而迎来2015年新一轮的城市更新,这正是旅游与城市更新相互作用的结果。由此,以乌镇为例,从开发背景、开发历程、开发理念、旅游产品、空间全域化等角度,对1999年《乌镇古镇保护规划》与2015年清华同衡的乌镇概念性总体规划"互联网时代的共生城市"2次新旧时代规划进行分析,思考新旧时代规划实践下,旅游对城市更新在地方特色、环境保护、区域联动等方面的驱动以及城市更新对旅游产业的反哺作用。

“产城创”驱动下城市科创走廊协同发展评估研究——以厦泉科创走廊为例

Science and technology innovation corridors are important spatial carriers for the coordinated development of future urban agglomerations in China.Based on a coupling coordination evaluation method,this study builds an index system for the evaluation of collaborative development of the"industry-city-innovation"region,and conducts the index evaluation and coupling coordination evaluation on the"industry-city-innovation"in the Xiamen-Quanzhou Science and Technology Innovation Corridor,in the hope of exploring measurement and evaluation methods for the de-velopment level of science and technology industrial parks.Based on multidimensional quantitative evaluation,the study concludes that Xiamen and Quanzhou own a solid foundation for economic development and science and technology innovation.However,the difference in the innovation cultivation environment between the two cities is an apparent shortcoming in the construction of the science and technology innovation corridor.Moreover,according to the coupling coordination evaluation of the"industry-city-innovation"system,the result shows that the overall coupling coordination degree of Xiamen City is generally high.The various counties and districts along the Xiamen-Quanzhou Science and Technology Inno-vation Corridor are mainly affected by the coupling of"city innovation",forming an obvious spatial agglomeration form.The influence of industrial elements is relatively weak.At the same time,the study uses the gray correlation analysis method to evaluate the factors influencing the coupling co-ordination degree.It is found that in terms of the degree of influence,city>industry>innovation,and the proportion of age population of labor force,the public service index,and the proportion of added value of the tertiary industry are key factors.Finally,considering the collaborative development with"industry-city-innovation"as the driving force,this study puts forward specific policy suggestions for the construction of the Xiamen-Quanzhou Science and Technology Innovation Corridor based on the coupling evaluation results,providing a reference for the future development of science and technologyinnovation corridors.

药物固体分散体技术回顾与展望

固体分散体为改善难溶性药物的溶解度与生物利用度等问题提供了一种有效的技术方法,从其发现到现在已近60年,已有26个药物制剂品种先后获得FDA批准上市,而且固体分散体制备技术不断创新与发展,涌现出了静电纺丝法、超临界流体法及喷雾冷冻干燥技术等。笔者将对固体分散体技术与载体的发展历程进行回顾,以固体分散体制备技术方法与载体的发展为主线进行综述,并对其存在的问题进行分析与展望,期望为固体分散体制备技术的研发提供借鉴。

Pickering乳化技术及其在中药挥发油中的应用进展

Pickering乳化技术作为一种以固体粒子为稳定剂的新型乳化技术,已成为化学、材料科学、医药等研究领域的一个新热点,由于其具有高稳定性、低毒性、可生物相容性等特点,对改善中药挥发油的稳定性具有很好的应用优势。对Pickering乳化技术的发展历程、特点及其近年来在中药挥发油中的应用进展进行综述,以期为Pickering乳化技术在中药挥发油中的应用提供依据。

纳米晶体技术在肺吸入给药中的研究进展

肺吸入给药是可实现肺靶向或全身给药的理想给药途径。然而肺部结构特征的复杂性给开发肺吸入制剂研发带来了困难,纳米晶体技术为解决难溶性药物肺部给药提供了一种有效的方法,其粒径小,可克服肺部中存在的生理屏障,提高药物的生物利用度,近年来引起了药物制剂学家的广泛关注。本文围绕肺部给药的屏障及纳米晶体在肺吸入给药的应用展开综述,期望为促进难溶性药物肺部给药提供借鉴。