小儿乙型病毒性肝炎肝内HBV抗原特点与临床

用ABC法对小儿乙型肝炎肝组织标本113份进行乙型肝炎病毒(HBV)抗原检测,检出率乙肝表面抗原(HBsAg)82.9%、乙肝核心抗原(HBcAg)77.3%、前S_1蛋白(PreS_1)80.0%前S_2蛋白(PreS_2)87.9%。重型肝炎HBgAg及HBcAg检出率显著低于其它各型(P<0.025)。分布形态HBsAg弥漫型>包涵体型>膜型>周边型,HBcAg核型略多于浆型。讨论了HBV抗原检出率、分布特点与临床及PreS意义。

MALIGNANT HISTIOCYTOSIS: A STUDY ON CLINICOPATHOLOGICAL FEATURES AND CELL ORIGIN

Thirty- one autopsy cases previously diagnosed as malignant histiocytosis (MH) were studied by means of immunohistochemical staining. Antibodies detecting the formalin resistant epitopes on T- cells, B- cells and those of histiocyte/monocyte origin were used. It was shown that the malignant histiocytes reacted only to the cell markers derived from histlocyte/monocyte. and only a part of lymphocytes showed positive reaction to the T and B cell markers. It is suggested that the histiocyte/monocyte lineage is the possible origin of the malignant proliferating cells in MH. The clinicopathological features and the differentiation of MH from familial erythrophagocytic lymphohistiocytosis, virus-associated hemophagocytic syndrome and malignant lymphoma are described. The pathogenesis. the causes of death and the points for attention in the treatment of MH are also discussed.

儿童非何杰金淋巴瘤的DNA含量和免疫表型的研究

应用流式细胞术和免疫组化技术，对６３例儿童非何杰金淋巴瘤的ＤＮＡ含量、免疫表型和核仁组织区相关蛋白进行了研究，结果表明：异倍体率、Ａｇ－ＮＯＲ值及增殖指数（ＰＩ）随着组织学分级增高而增大，且ＰＩ可作为判断预后的一项定量指标；Ａｇ－ＮＯＲ与ＰＩ呈正相关；异倍体与二倍体肿瘤累积生存率无显著差异；累积生存率未定型淋巴瘤＞Ｔ细胞淋巴瘤＞Ｂ细胞淋巴瘤。

269例新生儿颅内出血的临床病理研究

新生儿颅内出血是新生儿时期常见病,也是引起新生儿死亡的重要原因之一,应高度重视和防止颅内出血的发生。生后第一周是颅内出血发病和死亡的高峰时期,颅内出血漏诊率高达55.4％,是值得围产期工作者机度重视的一个问题。提高颅内出血的诊断率除了思想上重视外,还应科学地改善诊断的技术设备。