To evaluate the inhibiting effect of Homoharringtonine （HHT） on the corneal haze after excimer laser photorefractive keratectomy （PRK） in rabbits. 18 healthy rabbits which underwent PRK were randomly divided into ...To evaluate the inhibiting effect of Homoharringtonine （HHT） on the corneal haze after excimer laser photorefractive keratectomy （PRK） in rabbits. 18 healthy rabbits which underwent PRK were randomly divided into three groups （A, B and C）. The refractive degree of ablation was - 10.0DS in each group. Group A was locally treated with a piece of filter paper soaked with 1 mg/ mL HHT for 5 min, and then the entire cornea was repeatedly irrigated with balance solution; Group B was dropped with 0.1 mg/mL HHT after PRK for 3 months; Group C was the control group, Corneal haze, histopathology, response, ect. were investigated. The corneal haze was significantly less in group A, while the difference between group B and group C was insignificant. Keratocytes and fibrocytes in corneal stroma were more active up to 3 months in group B and group C, Intraoperative use of topical HHT can reduce corneal haze after PRK in rabbits.展开更多
To evaluate the effect of phototherapeutic keratectomy combined with photorefractive ker- atectomy in the treatment of myopia with corneal scars, corneal epithelium was removed with laser plus scraping. Corneal scars...To evaluate the effect of phototherapeutic keratectomy combined with photorefractive ker- atectomy in the treatment of myopia with corneal scars, corneal epithelium was removed with laser plus scraping. Corneal scars were removed with PTK, followed by PRK for myopia. Healon was used to make corneal surface smoother during operation. 30 eyes of 24 cases of myopia with corneal scars were followed up for one year. Mean corrected vision was 0. 51 and myopic degree was -6. 42D ±4. 26D before operation. After operation, corneal scars of 21 eyes (70. 0%) were removed in oper- ative zone. The vision of 27 operated eyes (90. 0%) was equal to or better than best corrected vi- sion. Mean postoperative visual acuity was 0. 72. Corneal surface was smoother and astigmatism was reduced after the surgery. Our study showed that PTK combined with PRK is a safe and effective treatment for myopia with corneal scars.展开更多
文摘To evaluate the inhibiting effect of Homoharringtonine （HHT） on the corneal haze after excimer laser photorefractive keratectomy （PRK） in rabbits. 18 healthy rabbits which underwent PRK were randomly divided into three groups （A, B and C）. The refractive degree of ablation was - 10.0DS in each group. Group A was locally treated with a piece of filter paper soaked with 1 mg/ mL HHT for 5 min, and then the entire cornea was repeatedly irrigated with balance solution; Group B was dropped with 0.1 mg/mL HHT after PRK for 3 months; Group C was the control group, Corneal haze, histopathology, response, ect. were investigated. The corneal haze was significantly less in group A, while the difference between group B and group C was insignificant. Keratocytes and fibrocytes in corneal stroma were more active up to 3 months in group B and group C, Intraoperative use of topical HHT can reduce corneal haze after PRK in rabbits.
文摘To evaluate the effect of phototherapeutic keratectomy combined with photorefractive ker- atectomy in the treatment of myopia with corneal scars, corneal epithelium was removed with laser plus scraping. Corneal scars were removed with PTK, followed by PRK for myopia. Healon was used to make corneal surface smoother during operation. 30 eyes of 24 cases of myopia with corneal scars were followed up for one year. Mean corrected vision was 0. 51 and myopic degree was -6. 42D ±4. 26D before operation. After operation, corneal scars of 21 eyes (70. 0%) were removed in oper- ative zone. The vision of 27 operated eyes (90. 0%) was equal to or better than best corrected vi- sion. Mean postoperative visual acuity was 0. 72. Corneal surface was smoother and astigmatism was reduced after the surgery. Our study showed that PTK combined with PRK is a safe and effective treatment for myopia with corneal scars.
