目的比较臭氧与胶原酶治疗腰椎间盘突出症(LDH)的治疗效果,为临床合理选择治疗方式提供循证医学依据。方法计算机检索PubMed、CENTRAL、EMbase、the ISI Web of KnowledgeDatabases、VIP、CNKI、CBM和万方数据库,查找所有比较臭氧和胶...目的比较臭氧与胶原酶治疗腰椎间盘突出症(LDH)的治疗效果,为临床合理选择治疗方式提供循证医学依据。方法计算机检索PubMed、CENTRAL、EMbase、the ISI Web of KnowledgeDatabases、VIP、CNKI、CBM和万方数据库,查找所有比较臭氧和胶原酶治疗LDH的随机(RCT)或半随机对照试验(CCT),检索时限均为建库至2012年5月31日,同时手检纳入文献的参考文献。按纳入排除标准由2名医师独立进行文献的筛选、资料提取和质量评价后,采用STATA11.0软件进行荟萃分析。结果共纳入8个研究,897例患者。荟萃分析结果显示:①臭氧对胶原酶的有效率:相对危险度(RR)=1.03,95%CI(0.90,1.18),差异无统计学意义(P=0.684);②臭氧对胶原酶优良率:RR=1.02,95%CI(0.91,1.15),P=0.694,差异无统计学意义;③臭氧对胶原酶VAS评分:MD=0.08,95%CI(-0.47,0.63),差异无统计学意义(P=0.783)。基于系统评价结果,采用GRADE系统推荐分级方法评价证据质量及推荐等级,结果显示,证据水平均为低级,推荐强度为弱推荐。结论现有证据提示,对于LDH的治疗,臭氧与胶原酶具有相似的治疗效果。展开更多
There have been numerous studies done to explore the diagnostic performance of quanti- tative diffusion-weighted （DW） MR imaging to differentiate between benign and malignant pancre- atic masses. However, the result...There have been numerous studies done to explore the diagnostic performance of quanti- tative diffusion-weighted （DW） MR imaging to differentiate between benign and malignant pancre- atic masses. However, the results have been inconsistent. We performed a meta-analysis to investigate whether DW-MR imaging can differentiate between these two diseases. Databases including MEDLINE, EMBASE and Cochrane Library were utilized to find relevant articles published between January 2001 and January 2014. A Stata version 12.0 and a Meta-Disc version 1.4 were used to de- scribe primary results. Twelve studies with 594 patients, which fulfilled the inclusion criteria, were enrolled for the analysis. The pooled sensitivity and specificity of DW imaging was 0.91 （95% CI： 0.84, 0.95） and 0.86 （95% CI： 0.76, 0.93） respectively. The area under the curve of the summary re- ceiver operating characteristic was 0.95 （95% CI： 0.93, 0.96）. The results indicated that DW imaging might be a valuable tool for differentiating benign and malignant pancreatic masses.展开更多
文摘目的比较臭氧与胶原酶治疗腰椎间盘突出症(LDH)的治疗效果,为临床合理选择治疗方式提供循证医学依据。方法计算机检索PubMed、CENTRAL、EMbase、the ISI Web of KnowledgeDatabases、VIP、CNKI、CBM和万方数据库,查找所有比较臭氧和胶原酶治疗LDH的随机(RCT)或半随机对照试验(CCT),检索时限均为建库至2012年5月31日,同时手检纳入文献的参考文献。按纳入排除标准由2名医师独立进行文献的筛选、资料提取和质量评价后,采用STATA11.0软件进行荟萃分析。结果共纳入8个研究,897例患者。荟萃分析结果显示:①臭氧对胶原酶的有效率:相对危险度(RR)=1.03,95%CI(0.90,1.18),差异无统计学意义(P=0.684);②臭氧对胶原酶优良率:RR=1.02,95%CI(0.91,1.15),P=0.694,差异无统计学意义;③臭氧对胶原酶VAS评分:MD=0.08,95%CI(-0.47,0.63),差异无统计学意义(P=0.783)。基于系统评价结果,采用GRADE系统推荐分级方法评价证据质量及推荐等级,结果显示,证据水平均为低级,推荐强度为弱推荐。结论现有证据提示,对于LDH的治疗,臭氧与胶原酶具有相似的治疗效果。
基金supported by the Science Foundation for Distinguished Young Scholars of Sichuan Province,China(No.2012JQ0060)
文摘There have been numerous studies done to explore the diagnostic performance of quanti- tative diffusion-weighted （DW） MR imaging to differentiate between benign and malignant pancre- atic masses. However, the results have been inconsistent. We performed a meta-analysis to investigate whether DW-MR imaging can differentiate between these two diseases. Databases including MEDLINE, EMBASE and Cochrane Library were utilized to find relevant articles published between January 2001 and January 2014. A Stata version 12.0 and a Meta-Disc version 1.4 were used to de- scribe primary results. Twelve studies with 594 patients, which fulfilled the inclusion criteria, were enrolled for the analysis. The pooled sensitivity and specificity of DW imaging was 0.91 （95% CI： 0.84, 0.95） and 0.86 （95% CI： 0.76, 0.93） respectively. The area under the curve of the summary re- ceiver operating characteristic was 0.95 （95% CI： 0.93, 0.96）. The results indicated that DW imaging might be a valuable tool for differentiating benign and malignant pancreatic masses.
