背景与目的:肥胖和低体重与多种肿瘤的进展及预后相关。本研究探讨体重指数(body mass index,BMI)对鼻咽癌患者预后的影响,为判断鼻咽癌患者的预后提供参考。方法:从1990-2003年在中山大学肿瘤防治中心确诊为鼻咽癌的病例中随机抽取1489...背景与目的:肥胖和低体重与多种肿瘤的进展及预后相关。本研究探讨体重指数(body mass index,BMI)对鼻咽癌患者预后的影响,为判断鼻咽癌患者的预后提供参考。方法:从1990-2003年在中山大学肿瘤防治中心确诊为鼻咽癌的病例中随机抽取1489例,按照患者的BMI分为正常、低体重、超重和肥胖4组。采用生存分析对4组患者的预后进行综合比较分析。结果:低体重组、超重组和肥胖组患者的年龄、T分期、N分期和总分期与正常体重组相比其差异均有统计学意义(P<0.0001)。以低体重组为对照组,正常组、超重组和肥胖组的总生存率、无复发生存率和无转移生存率的相对危险度均小于1,并且随着体重的增加相对危险度逐渐降低。单因素生存分析结果显示,低体重组总生存率、无复发生存率和无转移生存率低于正常体重组和超重组、肥胖组(P<0.0001);多因素分析结果表显示,年龄、T分期、N分期和BMI分级均可作为显著的独立预后因素(P<0.05)。结论:治疗前低BMI鼻咽癌患者的总生存率、无复发生存率、无转移生存率较正常BMI患者下降。治疗前BMI可作为评价鼻咽癌患者预后的一个重要参考指标。展开更多
Background and Objective:Anemia can not only reduce the quality of life of patients with cancer,but also affect their survival.This study was to investigate the prognostic value of hemoglobin(Hb) level in patients wit...Background and Objective:Anemia can not only reduce the quality of life of patients with cancer,but also affect their survival.This study was to investigate the prognostic value of hemoglobin(Hb) level in patients with nasopharyngeal carcinoma(NPC) treated with radiotherapy.Methods:Clinical data of 520 NPC patients received definitive radiotherapy between 2000 and 2002 at Sun Yat-sen University Cancer Center were analyzed.Patients were stratified into normal Hb level and anemia groups according to their Hb levels before,during,and after radiation.Anemia was defined according to World Health Organization criteria as Hb level < 130 g/L in men and < 120 g/L in women.Hb continuous decrease group and non-decrease group were defined according to Hb changes in the patients during radiotherapy.Loco-regional recurrence-free survival(LRFS) and overall survival(OS) rates were estimated using the Kaplan-Meier method.Multivariate analysis was performed using the Cox model to analyze the prognostic factors.Results:Before radiation,the 5-year LRFS rates were 60.9% in anemia group and 63.9% in normal Hb level group(P = 0.337);the 5-year OS rates were 65.2% and 71.0%,respectively(P = 0.299).During radiation,the 5-year LRFS rates were 56.7% in anemia group and 67.9% in normal Hb level group(P = 0.013);the 5-year OS rates were 61.0% and 75.9%,respectively(P = 0.001).After radiation,the 5-year LRFS rates were 59.6% in anemia group and 64.9% in normal Hb level group(P = 0.169);the 5-year OS rates were 65.0% and 71.9%,respectively(P = 0.090).The 5-year LRFS and OS rates were significantly lower in Hb continuous decrease group than in Hb non-decrease group(59.1% vs.69.3%,P = 0.032;66.2% vs.76.4%,P=0.011).Multivariate analysis showed that the continuous decrease of Hb was an independent prognostic factor for OS.Conclusion:The change in Hb level during radiotherapy is an important prognostic factor affecting the OS of NPC patients.展开更多
目的:研究吴茱萸碱对高脂血症小鼠脂质代谢及低密度脂蛋白-受体(LDL-R) m RNA表达的影响。方法:昆明种小鼠(n=80)随机分为正常组(n=20)和模型组(n=60)。模型组高脂饲料饲养3周后检测血脂,造模成功后随机分每5组,每组10只,模型组(等量生...目的:研究吴茱萸碱对高脂血症小鼠脂质代谢及低密度脂蛋白-受体(LDL-R) m RNA表达的影响。方法:昆明种小鼠(n=80)随机分为正常组(n=20)和模型组(n=60)。模型组高脂饲料饲养3周后检测血脂,造模成功后随机分每5组,每组10只,模型组(等量生理盐水)、阳性药组(辛伐他汀5 mg·kg-1),给药组(吴茱萸碱5. 25,10. 5,21 mg·kg-1),给药3周。苏木素-伊红(HE)染色切片观察小鼠肝细胞结构及主动脉弓粥样改变程度,用酶联免疫试剂盒测试各小鼠血清中总胆固醇(TC),甘油三酯(TG),高密度脂蛋白胆固醇(HDL-C),低密度脂蛋白胆固醇(LDL-C)与血清总脂联素(ADPN)的含量。采用逆转录-聚合酶链式反应(RT-PCR)的方法,检测各组小鼠肝脏LDL-R m RNA的表达。结果:HE染色切片可见模型组小鼠肝细胞肿胀并伴有脂肪变性,吴茱萸碱高、中剂量及辛伐他汀组可改善肝脏脂肪变性。模型组小鼠主动脉弓管壁有损伤、有明显内膜增厚现象、炎细胞浸润;吴茱萸碱低剂量组内膜增厚明显,高剂量组小鼠主动脉血管壁结构较清晰,少见内皮损伤。与正常组比较,模型组小鼠血清中TC,TG,LDL-C升高,HDL-C水平降低(P <0. 01);与模型组比较,吴茱萸碱中、高剂量组小鼠血清TC,TG水平降低,吴茱萸碱低、中、高剂量组LDL-C降低,HDL-C水平升高(P <0. 05,P <0. 01)。与正常组比较,模型组脂联素水平降低,与模型组比较,吴茱萸碱中、高剂量组的血清脂联素水平明显升高(P <0. 01)。与正常组比较,模型组小鼠肝脏LDL-R m RNA的表达明显降低(P <0. 01);与模型组比较,吴茱萸碱中、高剂量组LDL-R m RNA表达明显增强(P <0. 01)。结论:吴茱萸碱能改善高脂血症小鼠肝脏病变、主动脉粥样硬化趋势,可能与通过调节脂联素水平,降低小鼠血脂含量及上调小鼠肝脏LDL-R m RNA的表达有关。展开更多
文摘背景与目的:肥胖和低体重与多种肿瘤的进展及预后相关。本研究探讨体重指数(body mass index,BMI)对鼻咽癌患者预后的影响,为判断鼻咽癌患者的预后提供参考。方法:从1990-2003年在中山大学肿瘤防治中心确诊为鼻咽癌的病例中随机抽取1489例,按照患者的BMI分为正常、低体重、超重和肥胖4组。采用生存分析对4组患者的预后进行综合比较分析。结果:低体重组、超重组和肥胖组患者的年龄、T分期、N分期和总分期与正常体重组相比其差异均有统计学意义(P<0.0001)。以低体重组为对照组,正常组、超重组和肥胖组的总生存率、无复发生存率和无转移生存率的相对危险度均小于1,并且随着体重的增加相对危险度逐渐降低。单因素生存分析结果显示,低体重组总生存率、无复发生存率和无转移生存率低于正常体重组和超重组、肥胖组(P<0.0001);多因素分析结果表显示,年龄、T分期、N分期和BMI分级均可作为显著的独立预后因素(P<0.05)。结论:治疗前低BMI鼻咽癌患者的总生存率、无复发生存率、无转移生存率较正常BMI患者下降。治疗前BMI可作为评价鼻咽癌患者预后的一个重要参考指标。
基金Hi-Te ch Research and Development Program of China (No 2006AA02Z4B4)
文摘Background and Objective:Anemia can not only reduce the quality of life of patients with cancer,but also affect their survival.This study was to investigate the prognostic value of hemoglobin(Hb) level in patients with nasopharyngeal carcinoma(NPC) treated with radiotherapy.Methods:Clinical data of 520 NPC patients received definitive radiotherapy between 2000 and 2002 at Sun Yat-sen University Cancer Center were analyzed.Patients were stratified into normal Hb level and anemia groups according to their Hb levels before,during,and after radiation.Anemia was defined according to World Health Organization criteria as Hb level < 130 g/L in men and < 120 g/L in women.Hb continuous decrease group and non-decrease group were defined according to Hb changes in the patients during radiotherapy.Loco-regional recurrence-free survival(LRFS) and overall survival(OS) rates were estimated using the Kaplan-Meier method.Multivariate analysis was performed using the Cox model to analyze the prognostic factors.Results:Before radiation,the 5-year LRFS rates were 60.9% in anemia group and 63.9% in normal Hb level group(P = 0.337);the 5-year OS rates were 65.2% and 71.0%,respectively(P = 0.299).During radiation,the 5-year LRFS rates were 56.7% in anemia group and 67.9% in normal Hb level group(P = 0.013);the 5-year OS rates were 61.0% and 75.9%,respectively(P = 0.001).After radiation,the 5-year LRFS rates were 59.6% in anemia group and 64.9% in normal Hb level group(P = 0.169);the 5-year OS rates were 65.0% and 71.9%,respectively(P = 0.090).The 5-year LRFS and OS rates were significantly lower in Hb continuous decrease group than in Hb non-decrease group(59.1% vs.69.3%,P = 0.032;66.2% vs.76.4%,P=0.011).Multivariate analysis showed that the continuous decrease of Hb was an independent prognostic factor for OS.Conclusion:The change in Hb level during radiotherapy is an important prognostic factor affecting the OS of NPC patients.
