用二对氯苄基二氯化锡分别与对甲基苯甲酰肼缩苯甲酰甲酸及苯甲酰肼缩苯甲酰甲酸反应,合成了2个对氯苄基锡配合物(C1、C2),通过元素分析、IR、1 H NMR、13C NMR、119Sn NMR、HRMS以及X射线单晶衍射等表征了配合物结构。测试了配合物C1...用二对氯苄基二氯化锡分别与对甲基苯甲酰肼缩苯甲酰甲酸及苯甲酰肼缩苯甲酰甲酸反应,合成了2个对氯苄基锡配合物(C1、C2),通过元素分析、IR、1 H NMR、13C NMR、119Sn NMR、HRMS以及X射线单晶衍射等表征了配合物结构。测试了配合物C1、C2的热稳定性以及配合物对癌细胞NCI‑H460、HepG2、MCF7的体外抑制活性,发现配合物C2对癌细胞NCI‑H460、HepG2、MCF7等均表现出良好的抑制作用。利用紫外吸收光谱、荧光猝灭光谱以及粘度法研究了配合物C2与ct‑DNA之间的相互作用,结果表明配合物C2以插入模式与DNA结合。展开更多
Di-2,4-dichlorobenzyltin-2-(2-(thiophen-2-formyl)hydrazono)-propanoic carboxylate complex I{[C_(4)H_(3)S(O)C=N-N=C(CH_(3))COO]_(2)[(2,4-Cl_(2)-C_(6)H_(3)CH_(2))_(2)Sn]_(2)(CH_(3)OH)_(2)}and di-2,4-dichlorobenzyltin-2-...Di-2,4-dichlorobenzyltin-2-(2-(thiophen-2-formyl)hydrazono)-propanoic carboxylate complex I{[C_(4)H_(3)S(O)C=N-N=C(CH_(3))COO]_(2)[(2,4-Cl_(2)-C_(6)H_(3)CH_(2))_(2)Sn]_(2)(CH_(3)OH)_(2)}and di-2,4-dichlorobenzyltin-2-(2-(thio-phen-2-formyl)hydrazono)-3-phenylpropanoic carboxylate complexⅡ{[C_(4)H_(3)S(O)C=N-N=C(PhCH_(2))COO](2,4-Cl_(2)-C_(6)H_(3)CH_(2))_(2)Sn}n were synthesized and characterized by IR,^(1)H,^(13)C and^(119)Sn NMR spectra,HRMS,elemental analysis and thermal stability analysis,and the crystal structures were determined by X-ray diffraction.The crystal of complex I belongs to monoclinic system,space group P2_(1/n)with a=11.987(3),b=35.359(9),c=12.982(3)Å,β=103.028(5)°,Z=4,V=5361(2)Å3,Dc=1.688 Mg·m^(–3),μ(MoKα)=1.463 mm^(–1),F(000)=2704,R=0.0572 and wR=0.1423.The crystal of complexⅡis of monoclinic system,space group P2_(1/n)with a=15.5758(17),b=9.6020(10),c=19.599(2)Å,β=98.886(2)°,Z=4,V=2896.0(5)Å3,Dc=1.663 Mg·m^(–3),μ(MoKα)=1.357 mm^(–1),F(000)=1440,R=0.0341 and wR=0.0936.In vitro antitumor activities of both complexes were evaluated by MTT against three human cancer cell lines(MCF7,NCI-H460 and HepG2),and they all exhibited good antitumor activity.The interaction between complexes and calf thymus DNA was studied by UV-vis and fluorescence spectroscopy,it indicated intercalation as probable mode of interaction.展开更多
文摘用二对氯苄基二氯化锡分别与对甲基苯甲酰肼缩苯甲酰甲酸及苯甲酰肼缩苯甲酰甲酸反应,合成了2个对氯苄基锡配合物(C1、C2),通过元素分析、IR、1 H NMR、13C NMR、119Sn NMR、HRMS以及X射线单晶衍射等表征了配合物结构。测试了配合物C1、C2的热稳定性以及配合物对癌细胞NCI‑H460、HepG2、MCF7的体外抑制活性,发现配合物C2对癌细胞NCI‑H460、HepG2、MCF7等均表现出良好的抑制作用。利用紫外吸收光谱、荧光猝灭光谱以及粘度法研究了配合物C2与ct‑DNA之间的相互作用,结果表明配合物C2以插入模式与DNA结合。
基金the Natural Science Foundation of Hunan Province(No.2020JJ8096)。
文摘Di-2,4-dichlorobenzyltin-2-(2-(thiophen-2-formyl)hydrazono)-propanoic carboxylate complex I{[C_(4)H_(3)S(O)C=N-N=C(CH_(3))COO]_(2)[(2,4-Cl_(2)-C_(6)H_(3)CH_(2))_(2)Sn]_(2)(CH_(3)OH)_(2)}and di-2,4-dichlorobenzyltin-2-(2-(thio-phen-2-formyl)hydrazono)-3-phenylpropanoic carboxylate complexⅡ{[C_(4)H_(3)S(O)C=N-N=C(PhCH_(2))COO](2,4-Cl_(2)-C_(6)H_(3)CH_(2))_(2)Sn}n were synthesized and characterized by IR,^(1)H,^(13)C and^(119)Sn NMR spectra,HRMS,elemental analysis and thermal stability analysis,and the crystal structures were determined by X-ray diffraction.The crystal of complex I belongs to monoclinic system,space group P2_(1/n)with a=11.987(3),b=35.359(9),c=12.982(3)Å,β=103.028(5)°,Z=4,V=5361(2)Å3,Dc=1.688 Mg·m^(–3),μ(MoKα)=1.463 mm^(–1),F(000)=2704,R=0.0572 and wR=0.1423.The crystal of complexⅡis of monoclinic system,space group P2_(1/n)with a=15.5758(17),b=9.6020(10),c=19.599(2)Å,β=98.886(2)°,Z=4,V=2896.0(5)Å3,Dc=1.663 Mg·m^(–3),μ(MoKα)=1.357 mm^(–1),F(000)=1440,R=0.0341 and wR=0.0936.In vitro antitumor activities of both complexes were evaluated by MTT against three human cancer cell lines(MCF7,NCI-H460 and HepG2),and they all exhibited good antitumor activity.The interaction between complexes and calf thymus DNA was studied by UV-vis and fluorescence spectroscopy,it indicated intercalation as probable mode of interaction.
