病毒性脑炎作为影响世界公共卫生的主要疾病之一,是一种严重的中枢神经系统感染。白细胞计数的升高通常与感染和炎症相关,PCT是一种在感染时血浆中浓度升高的蛋白质,IL-6在急性炎症中起着重要作用,S100蛋白则往往代表了神经损伤和炎症...病毒性脑炎作为影响世界公共卫生的主要疾病之一,是一种严重的中枢神经系统感染。白细胞计数的升高通常与感染和炎症相关,PCT是一种在感染时血浆中浓度升高的蛋白质,IL-6在急性炎症中起着重要作用,S100蛋白则往往代表了神经损伤和炎症。在病毒性脑炎中,上述指标均可能发生变化。现本文对上述指标与重症病毒性脑炎的相关性做简要综述,以期为重症病毒性脑炎早期识别提供更多依据。Viral encephalitis, as one of the major diseases affecting global public health, is a serious central nervous system infection. The increase in white blood cell count is usually associated with infection and inflammation. PCT is a protein that increases in concentration in the plasma during infection, IL-6 plays an important role in acute inflammation, and S100 protein often represents nerve damage and inflammation. In viral encephalitis, the above indicators may undergo changes. This article provides a brief review of the correlation between the above indicators and severe viral encephalitis, in order to provide more evidence for early identification of severe viral encephalitis.展开更多
文摘目的 基于c-Jun氨基末端激酶(JNK)-p62/螯合体(SQSTM1)信号通路探讨糖肾煎对2型糖尿病肾病(DN)大鼠足细胞的保护作用。方法 SD大鼠随机分成正常组、DN组、糖肾煎低、中、高[生药5、10、20 g/(kg·d)]剂量组(糖肾煎-L、M、H组)、二甲双胍组[100 mg/(kg·d)]。除正常组外,其余各组通过喂养高脂高糖饲料和腹腔注射链脲佐菌素(STZ)进行DN模型构建。药物干预结束后,检测大鼠血生化指标空腹血糖(FBG)、负荷后2 h血糖(P2 h BG)、血肌酐(SCr)、血尿素氮(BUN)水平;苏木素-伊红(HE)、六胺银(PASM)染色观察肾组织病理学变化;透射电镜(TEM)观察肾小球基底膜损伤和足细胞变化情况;Western印迹检测肾组织中微管相关蛋白1A/1B-轻链(LC)3、p-JNK、JNK、p62/SQSTM1、肾病蛋白(Nephrin)蛋白表达。结果 与正常组比较,DN组FBG、P2 h BG、SCr、BUN水平及p62/SQSTM1蛋白表达明显升高,LC3-Ⅱ、Nephrin蛋白表达和p-JNK/JNK明显降低(P<0.05);光镜下观察到肾小球缩小、管丛系膜明显扩张,并有基底膜增生增厚等现象;TEM下观察到肾小球基底膜增厚、足细胞排列紊乱、形态改变、足突融合等现象。与DN组比较,糖肾煎-L、M、H组和二甲双胍组FBG、P2 h BG、SCr、BUN水平及p62/SQSTM1蛋白表达明显降低,LC3-Ⅱ、Nephrin蛋白表达和p-JNK/JNK明显升高(P<0.05);并且肾小球基底膜增厚、足细胞足突融合等情况均获得一定程度减轻。结论 糖肾煎对2型DN大鼠足细胞具有一定保护作用,可能是通过调控JNK-p62/SQSTM1信号通路,提高足细胞自噬,从而起到肾脏保护功效。
文摘病毒性脑炎作为影响世界公共卫生的主要疾病之一,是一种严重的中枢神经系统感染。白细胞计数的升高通常与感染和炎症相关,PCT是一种在感染时血浆中浓度升高的蛋白质,IL-6在急性炎症中起着重要作用,S100蛋白则往往代表了神经损伤和炎症。在病毒性脑炎中,上述指标均可能发生变化。现本文对上述指标与重症病毒性脑炎的相关性做简要综述,以期为重症病毒性脑炎早期识别提供更多依据。Viral encephalitis, as one of the major diseases affecting global public health, is a serious central nervous system infection. The increase in white blood cell count is usually associated with infection and inflammation. PCT is a protein that increases in concentration in the plasma during infection, IL-6 plays an important role in acute inflammation, and S100 protein often represents nerve damage and inflammation. In viral encephalitis, the above indicators may undergo changes. This article provides a brief review of the correlation between the above indicators and severe viral encephalitis, in order to provide more evidence for early identification of severe viral encephalitis.
