We had given evidences of cytocidal effect in vitro of either parvovirus H-I(PV H-1) or AT-1840 (lycobetaine) on gastric cancer cells. They act on different phase of the cell cycle of the gastric cancer cells, with PV...We had given evidences of cytocidal effect in vitro of either parvovirus H-I(PV H-1) or AT-1840 (lycobetaine) on gastric cancer cells. They act on different phase of the cell cycle of the gastric cancer cells, with PV H-1 on the late stage of S phase and AT-1840 on M phase. Combined use of these drugs gives better killing effect than the individual drug alone. In gastric cancer-bearing nude mice (ascites and solid tumor forms), both AT-1840 and PV H-1 increased the survival peroids and decreased the size of solid tumors. Depsite these are the experimental study which may not to be the same in human being. However, the study has layed down a solid foundation for our further exploration of these two substances as anti-gastric cancer drugs in the future.展开更多
Although several tens of detecting systems have since been established to test the environmental mutagens and carcinogens, each of them inevitably possesses its limitation for application. This study describes a newly...Although several tens of detecting systems have since been established to test the environmental mutagens and carcinogens, each of them inevitably possesses its limitation for application. This study describes a newly developed system, the parvovirus/human cell system.The autonomous parvovirus H-1 contains a linear single-stranded DNA展开更多
文摘We had given evidences of cytocidal effect in vitro of either parvovirus H-I(PV H-1) or AT-1840 (lycobetaine) on gastric cancer cells. They act on different phase of the cell cycle of the gastric cancer cells, with PV H-1 on the late stage of S phase and AT-1840 on M phase. Combined use of these drugs gives better killing effect than the individual drug alone. In gastric cancer-bearing nude mice (ascites and solid tumor forms), both AT-1840 and PV H-1 increased the survival peroids and decreased the size of solid tumors. Depsite these are the experimental study which may not to be the same in human being. However, the study has layed down a solid foundation for our further exploration of these two substances as anti-gastric cancer drugs in the future.
基金Project supported by the Youth Scientific Funds of Fudan University.
文摘Although several tens of detecting systems have since been established to test the environmental mutagens and carcinogens, each of them inevitably possesses its limitation for application. This study describes a newly developed system, the parvovirus/human cell system.The autonomous parvovirus H-1 contains a linear single-stranded DNA
