目的评价舌三针埋线疗法联合高频重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)治疗脑卒中后吞咽障碍的疗效及安全性。方法将成都市第二人民医院康复科2019年1月至2020年2月住院治疗的60例脑卒中后吞咽障碍患者...目的评价舌三针埋线疗法联合高频重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)治疗脑卒中后吞咽障碍的疗效及安全性。方法将成都市第二人民医院康复科2019年1月至2020年2月住院治疗的60例脑卒中后吞咽障碍患者随机分为常规治疗组、rTMS治疗组、联合治疗组,每组20例。3组患者均予内科基础治疗,常规治疗组采用吞咽直接训练和间接训练,rTMS组除采用常规治疗组方案加rTMS治疗方案,联合治疗组采用rTMS组治疗方案外加舌三针埋线疗法治疗。治疗前后采用洼田饮水试验(water swallowing test,WST)量表、标准吞咽功能评价(standardized swallowing assessment,SSA)量表、吞咽障碍特异性生活质量(swallowing quality of life questionnaire,SWAL-QOL)量表评价患者吞咽功能,采用洼田吞咽能力评定量表评价疗效,并观察不良反应。结果联合治疗组总有效率为94.7%,rTMS治疗组为88.9%,常规治疗组为68.4%,两两比较差异均有统计学意义(P<0.05)。治疗后,3组患者WST评分、SSA评分、SWAL-QOL评分均较治疗前有显著改善(P<0.05);且联合治疗组、rTMS治疗组均优于常规治疗组(P<0.05),联合治疗组优于rTMS治疗组(P<0.05)。3组均未出现严重不良反应。结论舌三针埋线疗法联合rTMS疗法能更好地改善患者脑卒中后的吞咽功能,减少误吸,提升患者生活质量和精神状态,值得临床推广。展开更多
Aerosol-bound organic radicals,including environmentally persistent free radicals(EPFRs),are key components that affect climate,air quality,and human health.While putative structures have been proposed,the molecular c...Aerosol-bound organic radicals,including environmentally persistent free radicals(EPFRs),are key components that affect climate,air quality,and human health.While putative structures have been proposed,the molecular characteristics of EPFRs remain unknown.Here,we report a surrogate method to characterize EPFRs in real ambient samples using mass spectrometry.The method identifies chemically relevant oxygenated polycyclic aromatic hydrocarbons(OxPAH)that interconvert with oxygen-centered EPFR(OC-EPFR).We found OxPAH compounds most relevant to OC-EPFRs are structurally rich and diverse quinones,whose diversity is strongly associated with OC-EPFR levels.Both atmospheric oxidation and combustion contributed to OC-EPFR formation.Redundancy analysis and photochemical aging model show pyrolytic sources generated more oxidized OC-EPFRs than photolytic sources.Our study reveals the detailed molecular characteristics of OC-EPFRs and shows that oxidation states can be used to identify the origins of OC-EPFRs,offering a way to track the development and evolution of aerosol particles in the environment.展开更多
文摘目的评价舌三针埋线疗法联合高频重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)治疗脑卒中后吞咽障碍的疗效及安全性。方法将成都市第二人民医院康复科2019年1月至2020年2月住院治疗的60例脑卒中后吞咽障碍患者随机分为常规治疗组、rTMS治疗组、联合治疗组,每组20例。3组患者均予内科基础治疗,常规治疗组采用吞咽直接训练和间接训练,rTMS组除采用常规治疗组方案加rTMS治疗方案,联合治疗组采用rTMS组治疗方案外加舌三针埋线疗法治疗。治疗前后采用洼田饮水试验(water swallowing test,WST)量表、标准吞咽功能评价(standardized swallowing assessment,SSA)量表、吞咽障碍特异性生活质量(swallowing quality of life questionnaire,SWAL-QOL)量表评价患者吞咽功能,采用洼田吞咽能力评定量表评价疗效,并观察不良反应。结果联合治疗组总有效率为94.7%,rTMS治疗组为88.9%,常规治疗组为68.4%,两两比较差异均有统计学意义(P<0.05)。治疗后,3组患者WST评分、SSA评分、SWAL-QOL评分均较治疗前有显著改善(P<0.05);且联合治疗组、rTMS治疗组均优于常规治疗组(P<0.05),联合治疗组优于rTMS治疗组(P<0.05)。3组均未出现严重不良反应。结论舌三针埋线疗法联合rTMS疗法能更好地改善患者脑卒中后的吞咽功能,减少误吸,提升患者生活质量和精神状态,值得临床推广。
基金supported by the National Natural Science Foundation of China(92143301 and 91843301)the National Key Research and Development Program of China(2020YFF01014504)the Chinese Academy Sciences Youth Innovation Promotion Association projects。
文摘Aerosol-bound organic radicals,including environmentally persistent free radicals(EPFRs),are key components that affect climate,air quality,and human health.While putative structures have been proposed,the molecular characteristics of EPFRs remain unknown.Here,we report a surrogate method to characterize EPFRs in real ambient samples using mass spectrometry.The method identifies chemically relevant oxygenated polycyclic aromatic hydrocarbons(OxPAH)that interconvert with oxygen-centered EPFR(OC-EPFR).We found OxPAH compounds most relevant to OC-EPFRs are structurally rich and diverse quinones,whose diversity is strongly associated with OC-EPFR levels.Both atmospheric oxidation and combustion contributed to OC-EPFR formation.Redundancy analysis and photochemical aging model show pyrolytic sources generated more oxidized OC-EPFRs than photolytic sources.Our study reveals the detailed molecular characteristics of OC-EPFRs and shows that oxidation states can be used to identify the origins of OC-EPFRs,offering a way to track the development and evolution of aerosol particles in the environment.
