This paper describes the evolution of vapour bubbles and its effect on nonlinear ultrasound propagation and temperature rise through tissues for therapeutic ultrasound. An acoustic-thermo coupling algorithm incorporat...This paper describes the evolution of vapour bubbles and its effect on nonlinear ultrasound propagation and temperature rise through tissues for therapeutic ultrasound. An acoustic-thermo coupling algorithm incorporating nonlinearity, diffraction, and temperature-dependent tissue properties, is employed to describe nonlinear ultrasound propagation and thermal effect. Results demonstrate that an obvious migration of peak pressure toward transducer surface is observed while the position of peak temperature changes little in liver tissue before the generation of vapour bubbles, and that the boiling region enlarges towards the surface of transducer in axial direction but increases slowly in radial direction after the generation of vapour bubbles.展开更多
The relationship between the cavitation and acoustic peak negative pressure in the high-intensity focused ultrasound （HIFU） field is analyzed in water and tissue phantom. The peak negative pressure at the focus is d...The relationship between the cavitation and acoustic peak negative pressure in the high-intensity focused ultrasound （HIFU） field is analyzed in water and tissue phantom. The peak negative pressure at the focus is determined by a hybrid approach combining the measurement with the simulation. The spheroidal beam equation is utilized to describe the nonlinear acoustic propagation. The waveform at the focus is measured by a fiber optic probe hydrophone in water. The relationship between the source pressure amplitude and the excitation voltage is determined by fitting the measured ratio of the second harmonic to the fundamental component at the focus, based on the model simulation. Then the focal negative pressure is calculated for arbitrary voltage excita- tion in water and tissue phantom. A portable B-mode ultrasound scanner is applied to monitor HIFU-indueed cavitation in real time, and a passive cavitation detection （PCD） system is used to acquire the bubble scattering signals in the HIFU focal volume for the cavitation quantification. The results show that： （1） unstable cavitation starts to appear in degassed water when the peak negative pressure of HIFU signals reaches 13.5 MPa; and （2） the cavitation activity can be detected in tissue phantom by B-mode images and in the PCD system with HIFU peak negative pressures of 9.0 MPa and 7.8 MPa, respectively, which suggests that real-time B-mode images could be used to monitor the cavitation activity in two dimensions, while PCD systems are more sensitive to detect scattering and emission signals from cavitation bubbles.展开更多
Sub-harmonic component generated from microbubbles is proven to be potentially used in noninvasive blood pressure measurement. Both theoretical and experimental studies are performed in the present work to investigate...Sub-harmonic component generated from microbubbles is proven to be potentially used in noninvasive blood pressure measurement. Both theoretical and experimental studies are performed in the present work to investigate the dependence of the sub-harmonic generation on the overpressure with different excitation pressure amplitudes and pulse lengths. With 4-MHz ultrasound excitation at an applied acoustic pressure amplitude of 0.24 MPa, the measured sub-harmonic amplitude exhibits a decreasing change as overpressure increases; while non-monotonic change is observed for the applied acoustic pressures of 0.36 MPa and 0.48 MPa, and the peak position in the curve of the sub-harmonic response versus the overpres- sure shifts toward higher overpressure as the excitation pressure amplitude increases. Furthermore, the exciting pulse with long duration could lead to a better sensitivity of the sub-harmonic response to overpressure. The measured results are ex- plained by the numerical simulations based on the Marmottant model. The numerical simulations qualitatively accord with the measured results. This work might provide a preliminary proof for the optimization of the noninvasive blood pressure measurement through using sub-harmonic generation from microbubbles.展开更多
This article theoretically studies the influence of inhomogeneous abdominal walls on focused therapeutic ultrasound based on the phase screen model. An inhomogeneous tissue is considered as a combination of a homogene...This article theoretically studies the influence of inhomogeneous abdominal walls on focused therapeutic ultrasound based on the phase screen model. An inhomogeneous tissue is considered as a combination of a homogeneous medium and a phase aberration screen. Variations of acoustic parameters such as peak positive pressure, peak negative pressure, and acoustic intensity are discussed with respect to the phase screen statistics of human abdominal walls. Results indicate that the abdominal wall can result in energy loss of the sound in the focal plane. For a typical human abdominal wall with correlation length of 7.9 mm and variance of 0.36, the peak acoustic intensity radiated from a 1MHz transmitter with a radius of 30 mm can be reduced by about 14% at the focal plane.展开更多
Hyperthermia effects （39-44 ℃） induced by pulsed high-intensity focused ultrasound （HIFU） have been regarded as a promising therapeutic tool for boosting immune responses or enhancing drug delivery into a solid t...Hyperthermia effects （39-44 ℃） induced by pulsed high-intensity focused ultrasound （HIFU） have been regarded as a promising therapeutic tool for boosting immune responses or enhancing drug delivery into a solid tumor. However, previous studies also reported that the cell death occurs when cells are maintained at 43 ℃ for more than 20 minutes. The aim of this study is to investigate thermal responses inside in vivo rabbit auricular veins exposed to pulsed HIFU （1.17 MHz, 5300 W/cm2, with relatively low-duty ratios （0.2%-4.3%）. The results show that： （1） with constant pulse repetition frequency （PRF） （e.g., 1 Hz）, the thermal responses inside the vessel will increase with the increasing duty ratio; （2） a temperature elevation to 43 ℃ can be identified at the duty ratio of 4.3%; （3） with constant duty ratios, the change of PRF will not significantly affect the temperature measurement in the vessel; （4） as the duty ratios lower than 4.3%, the presence of microbubbles will not significantly enhance the thermal responses in the vessel, but will facilitate HIFU-induced inertial cavitation events.展开更多
A combined time and frequency domain method is developed for the calculation of a shock wave induced by a strong focused ultrasound transducer in the oblate spheroidal coordinate system.The spheroidal beam equation(SB...A combined time and frequency domain method is developed for the calculation of a shock wave induced by a strong focused ultrasound transducer in the oblate spheroidal coordinate system.The spheroidal beam equation(SBE)is utilized to describe the nonlinear sound propagation;the diffraction and attenuation effects are calculated in the frequency-domain,while the nonlinear effect is calculated in the time-domain.Compared with the traditional frequency-domain method,this method could calculate the shock wave effectively without oscillation at the shock front and with less computation time.When the harmonic number is 200,the computation time by this method is about 1/16 of that used by the traditional frequency-domain method.展开更多
基金supported by Program for New Century Excellent Talents in University of China (06-0450)National Natural Science Foundation of China (Grant No 10474044)
文摘This paper describes the evolution of vapour bubbles and its effect on nonlinear ultrasound propagation and temperature rise through tissues for therapeutic ultrasound. An acoustic-thermo coupling algorithm incorporating nonlinearity, diffraction, and temperature-dependent tissue properties, is employed to describe nonlinear ultrasound propagation and thermal effect. Results demonstrate that an obvious migration of peak pressure toward transducer surface is observed while the position of peak temperature changes little in liver tissue before the generation of vapour bubbles, and that the boiling region enlarges towards the surface of transducer in axial direction but increases slowly in radial direction after the generation of vapour bubbles.
基金Supported by the National Natural Science Foundation of China under Grant Nos 81127901,81420108018,81527803,81227004 and 11374155the Natural Science Foundation of Jiangsu Province under Grant No BK20131017+3 种基金the Main Scientific and Technological Project of Zhejiang Province under Grant No 2013C03044-1the Chinese Postdoctoral Science Foundation under Grant No134238the Postdoctoral Foundation of Jiangsu Province under Grant No 1401001Bthe Qing Lan Project
文摘The relationship between the cavitation and acoustic peak negative pressure in the high-intensity focused ultrasound （HIFU） field is analyzed in water and tissue phantom. The peak negative pressure at the focus is determined by a hybrid approach combining the measurement with the simulation. The spheroidal beam equation is utilized to describe the nonlinear acoustic propagation. The waveform at the focus is measured by a fiber optic probe hydrophone in water. The relationship between the source pressure amplitude and the excitation voltage is determined by fitting the measured ratio of the second harmonic to the fundamental component at the focus, based on the model simulation. Then the focal negative pressure is calculated for arbitrary voltage excita- tion in water and tissue phantom. A portable B-mode ultrasound scanner is applied to monitor HIFU-indueed cavitation in real time, and a passive cavitation detection （PCD） system is used to acquire the bubble scattering signals in the HIFU focal volume for the cavitation quantification. The results show that： （1） unstable cavitation starts to appear in degassed water when the peak negative pressure of HIFU signals reaches 13.5 MPa; and （2） the cavitation activity can be detected in tissue phantom by B-mode images and in the PCD system with HIFU peak negative pressures of 9.0 MPa and 7.8 MPa, respectively, which suggests that real-time B-mode images could be used to monitor the cavitation activity in two dimensions, while PCD systems are more sensitive to detect scattering and emission signals from cavitation bubbles.
基金Supported by the Program for New Century Excellent Talents in University （06-0450）, the National Natural Science Foundation of China under Grant No 10774071, and the Natural Science Foundation of Jiangsu Province （BK2007518）.
基金Project supported by the National Basic Research Program from Ministry of Science and Technology,China(Grant No.2011CB707900)the National Natural Science Foundation of China(Grant Nos.81271589,81227004,11174141,11374155,11612032,and 81301616)the Natural Science Foundation of Jiangsu Province,China(Grant Nos.BE2011110 and BK20131017)
文摘Sub-harmonic component generated from microbubbles is proven to be potentially used in noninvasive blood pressure measurement. Both theoretical and experimental studies are performed in the present work to investigate the dependence of the sub-harmonic generation on the overpressure with different excitation pressure amplitudes and pulse lengths. With 4-MHz ultrasound excitation at an applied acoustic pressure amplitude of 0.24 MPa, the measured sub-harmonic amplitude exhibits a decreasing change as overpressure increases; while non-monotonic change is observed for the applied acoustic pressures of 0.36 MPa and 0.48 MPa, and the peak position in the curve of the sub-harmonic response versus the overpres- sure shifts toward higher overpressure as the excitation pressure amplitude increases. Furthermore, the exciting pulse with long duration could lead to a better sensitivity of the sub-harmonic response to overpressure. The measured results are ex- plained by the numerical simulations based on the Marmottant model. The numerical simulations qualitatively accord with the measured results. This work might provide a preliminary proof for the optimization of the noninvasive blood pressure measurement through using sub-harmonic generation from microbubbles.
基金Project supported by the Program for New Century Excellent Talents in University of China (Grant No 06-0450)the National Natural Science Foundation of China (Grant No 10774071)the Natural Science Foundation of Jiangsu Province, China (Grant No BK2007518)
文摘This article theoretically studies the influence of inhomogeneous abdominal walls on focused therapeutic ultrasound based on the phase screen model. An inhomogeneous tissue is considered as a combination of a homogeneous medium and a phase aberration screen. Variations of acoustic parameters such as peak positive pressure, peak negative pressure, and acoustic intensity are discussed with respect to the phase screen statistics of human abdominal walls. Results indicate that the abdominal wall can result in energy loss of the sound in the focal plane. For a typical human abdominal wall with correlation length of 7.9 mm and variance of 0.36, the peak acoustic intensity radiated from a 1MHz transmitter with a radius of 30 mm can be reduced by about 14% at the focal plane.
基金Supported by the National Basic Research Program of China under Grant Nos 2010CB732600 and 2011CB707900, and the National Natural Science Foundation of China under Grant Nos 10974093 and 10974098.
基金Project supported by the National Basic Research Program of China (Grant No. 2011CB707900)the National Natural Science Foundation of China (Grant Nos. 11074123, 10974095, 10904068, and 10204014)+2 种基金the Fundamental Research Funds for the Central Universities of China (Grant Nos. 111602040 and 1095020409)the Natural Science Foundation of Jiangsu Province of China (Grant No. BK2011812)the Priority Academic Program Development of Jiangsu Higher Educaton Institutions of China
文摘Hyperthermia effects （39-44 ℃） induced by pulsed high-intensity focused ultrasound （HIFU） have been regarded as a promising therapeutic tool for boosting immune responses or enhancing drug delivery into a solid tumor. However, previous studies also reported that the cell death occurs when cells are maintained at 43 ℃ for more than 20 minutes. The aim of this study is to investigate thermal responses inside in vivo rabbit auricular veins exposed to pulsed HIFU （1.17 MHz, 5300 W/cm2, with relatively low-duty ratios （0.2%-4.3%）. The results show that： （1） with constant pulse repetition frequency （PRF） （e.g., 1 Hz）, the thermal responses inside the vessel will increase with the increasing duty ratio; （2） a temperature elevation to 43 ℃ can be identified at the duty ratio of 4.3%; （3） with constant duty ratios, the change of PRF will not significantly affect the temperature measurement in the vessel; （4） as the duty ratios lower than 4.3%, the presence of microbubbles will not significantly enhance the thermal responses in the vessel, but will facilitate HIFU-induced inertial cavitation events.
基金Supported by the National Basic Research Program of China under Grant No 2011CB707900the National Natural Science Foundation of China under Grant Nos 81127901,11174141,81227004,11204144 and 11161120324+2 种基金the Natural Science Foundation of Jiangsu Province under Grant Nos BE2011110 and BK2012226the National High-Technology Research and Development Program of China under Grant No 2012AA022700the State Key Laboratory of Acoustics of Chinese Academy Sciences.
文摘A combined time and frequency domain method is developed for the calculation of a shock wave induced by a strong focused ultrasound transducer in the oblate spheroidal coordinate system.The spheroidal beam equation(SBE)is utilized to describe the nonlinear sound propagation;the diffraction and attenuation effects are calculated in the frequency-domain,while the nonlinear effect is calculated in the time-domain.Compared with the traditional frequency-domain method,this method could calculate the shock wave effectively without oscillation at the shock front and with less computation time.When the harmonic number is 200,the computation time by this method is about 1/16 of that used by the traditional frequency-domain method.
