Synthesis and bioactivities of new antagonists of luteinizing hormone releasing hormone(LHRH) with novel unnatural amino acids at position five are reported, Most of them showedsome antiovulatory activity at 0. 5μg/r...Synthesis and bioactivities of new antagonists of luteinizing hormone releasing hormone(LHRH) with novel unnatural amino acids at position five are reported, Most of them showedsome antiovulatory activity at 0. 5μg/rat and two of them inhibited ovulation completely at1μg/rat using saline as vehicle.展开更多
In the development of new peptide drugs, it is an important way to synthesize the analogs of bioactive peptide. There are different methods to obtain the analogs, including: (ⅰ) changing the backbond structure of a p...In the development of new peptide drugs, it is an important way to synthesize the analogs of bioactive peptide. There are different methods to obtain the analogs, including: (ⅰ) changing the backbond structure of a peptide; (ⅱ) changing the amino acid residues and (ⅲ) introducing D-amino acids into a peptide. In some cases, to get high potent analogs of a peptide, unnatural amino acids are needed.展开更多
基金This work was supported in part by grants from United Nations Fund for Population Activities (UNFPA) and State Family Planning Commission of China.
文摘Synthesis and bioactivities of new antagonists of luteinizing hormone releasing hormone(LHRH) with novel unnatural amino acids at position five are reported, Most of them showedsome antiovulatory activity at 0. 5μg/rat and two of them inhibited ovulation completely at1μg/rat using saline as vehicle.
文摘In the development of new peptide drugs, it is an important way to synthesize the analogs of bioactive peptide. There are different methods to obtain the analogs, including: (ⅰ) changing the backbond structure of a peptide; (ⅱ) changing the amino acid residues and (ⅲ) introducing D-amino acids into a peptide. In some cases, to get high potent analogs of a peptide, unnatural amino acids are needed.
