Cell type-specific genomic regulation is driven by the binding of transcription factors(TFs)in accessible genomic regions.Thus,chromatin accessibility can be used to identify cis-regulatory elements and directly depic...Cell type-specific genomic regulation is driven by the binding of transcription factors(TFs)in accessible genomic regions.Thus,chromatin accessibility can be used to identify cis-regulatory elements and directly depict cellular identity.Single-cell Assay for Transposase-Accessible Chromatin using sequencing(Single-cell ATAC-seq or scATAC-seq)has enabled genome-wide profiling of chromatin accessibility at single-cell resolution and can thus reveal epigenetic heterogeneity at cellular level[1].展开更多
基金supported by the National Key R&D Program of China(2019YFA0709501)the National Natural Science Foundation of China(61621003)+1 种基金the National Ten Thousand Talent Program for Young Top-notch Talents,the CAS Frontier Science Research Key Project for Top Young Scientist(QYZDB-SSW-SYS008)the Shanghai Municipal Science and Technology Major Project(2017SHZDZX01).
文摘Cell type-specific genomic regulation is driven by the binding of transcription factors(TFs)in accessible genomic regions.Thus,chromatin accessibility can be used to identify cis-regulatory elements and directly depict cellular identity.Single-cell Assay for Transposase-Accessible Chromatin using sequencing(Single-cell ATAC-seq or scATAC-seq)has enabled genome-wide profiling of chromatin accessibility at single-cell resolution and can thus reveal epigenetic heterogeneity at cellular level[1].