It has been known for years that steroids （e. g. hydrocortisone and dexamethasone） have significant inhibitory effects on macrophage （M φ） activation for tumor cytotoxicity and secretion of interleukin 1, tumor n...It has been known for years that steroids （e. g. hydrocortisone and dexamethasone） have significant inhibitory effects on macrophage （M φ） activation for tumor cytotoxicity and secretion of interleukin 1, tumor necrosis factor-α（TNF-α） and prostaglandin E<sub>2</sub>. The mechanism of inhibition is, however, not well understood. We report here that the dexamethasone-induced inhibition of M φ activation for tumor cytotoxicity could be partially antagonized by high concentrations of activators and blocked by inhibitors of protein synthesis and energy metabolism.展开更多
Fusarium moniliforme is a predominant fungus found in fungus-contaminated food in Linxian County, China, a high risk area of esophageal. cancer. Rats fed with corn bread inoculated with Fusarium moniliforme developed ...Fusarium moniliforme is a predominant fungus found in fungus-contaminated food in Linxian County, China, a high risk area of esophageal. cancer. Rats fed with corn bread inoculated with Fusarium moniliforme developed papillomas and squamous-cell carcinomas展开更多
文摘It has been known for years that steroids （e. g. hydrocortisone and dexamethasone） have significant inhibitory effects on macrophage （M φ） activation for tumor cytotoxicity and secretion of interleukin 1, tumor necrosis factor-α（TNF-α） and prostaglandin E<sub>2</sub>. The mechanism of inhibition is, however, not well understood. We report here that the dexamethasone-induced inhibition of M φ activation for tumor cytotoxicity could be partially antagonized by high concentrations of activators and blocked by inhibitors of protein synthesis and energy metabolism.
文摘Fusarium moniliforme is a predominant fungus found in fungus-contaminated food in Linxian County, China, a high risk area of esophageal. cancer. Rats fed with corn bread inoculated with Fusarium moniliforme developed papillomas and squamous-cell carcinomas
