Coarse-Grained Molecular Dynamics Simulation of a Red Blood Cell

A worm-like chain model based on a spectrin network is employed to study the biomechanics of red blood cells. Coarse-grained molecular dynamics simulations are performed to obtain a stable configuration free of external loadings. We also discuss the influence of two parameters： the average bending modulus and the persistence length. The change in shape of a malaria-infected red blood cell can contribute to the change in its molecular-based structure. As the persistence length of the membrane network in the infected red blood cell decreases, the deformability decreases and the biconcave shape is destroyed. The numerical results are comparable with previously reported experimental results. The coarse-grained model can be used to study the relationship between macro-mechanical properties and molecular-scale structures of cells.

浅析高中物理定律的学习探究和解题心得

高中物理是一门实验性、生活性非常强的学科,高中物理知识来源于实际生活,而实际生活中又处处存在着物理现象,在学习高中物理过程中不仅仅要掌握基本的定律、原理,其次还要加强对所学物理知识的探究与分析,充分掌握物理学习方法与解题规律,这样才能够对所学到的物理知识有较为透彻的理解与认知,并且利用所学到的物理知识解决实际生活问题,做到学以致用、融会贯通。