Photoacoustic tomography is a noninvasive and nonionized biomedical imaging modality but it cannot reveal the inner structure and sideward boundary information of blood vessels in the linear array detection mode.In co...Photoacoustic tomography is a noninvasive and nonionized biomedical imaging modality but it cannot reveal the inner structure and sideward boundary information of blood vessels in the linear array detection mode.In contrast,Monte Carlo（MC） light transport could provide the optical fluence distribution around the entire vascular area.This research explores the combination of linear array transducer-based photoacoustic tomography and MC light transport in the blood vessel quantification.Simulation,phantom,and in vivo experiments are in good correlation with the ultrasound imaging,validating this approach can clearly visualize the internal region of blood vessels from background tissue.展开更多
Photoacoustic tomography（PAT） has the unique capability of visualizing optical absorption inside several centimeters-deep biological tissue with a high spatial resolution. However, single linear-array transducer-bas...Photoacoustic tomography（PAT） has the unique capability of visualizing optical absorption inside several centimeters-deep biological tissue with a high spatial resolution. However, single linear-array transducer-based PAT suffers from the limited-view challenge, and thus the synthetic aperture configuration is designed that still requires multichannel data acquisition hardware. Herein, a feasible synthetic aperture PAT based on compressed sensing reconstruction is proposed. Both the simulation and experimental results tested the theoretical model and validated that this approach can improve the image resolution and address the limited-view problem while preserving the target information with a fewer number of measurements.展开更多
基金partially supported by the National Natural Science Foundation of China(Nos.61371045 and 11574064)the Shenzhen Science&Technology Program,China(No.JCYJ20160429115309834)+1 种基金the Science and Technology Development Plan Project of Shandong Province,China(Nos.2015GGX103016 and 2016GGX103032)the China Postdoctoral Science Foundation(No.2015M571413)
文摘Photoacoustic tomography is a noninvasive and nonionized biomedical imaging modality but it cannot reveal the inner structure and sideward boundary information of blood vessels in the linear array detection mode.In contrast,Monte Carlo（MC） light transport could provide the optical fluence distribution around the entire vascular area.This research explores the combination of linear array transducer-based photoacoustic tomography and MC light transport in the blood vessel quantification.Simulation,phantom,and in vivo experiments are in good correlation with the ultrasound imaging,validating this approach can clearly visualize the internal region of blood vessels from background tissue.
基金partially supported by the National Natural Science Foundation of China(Nos.61371045 and 11574064)the Shenzhen Science & Technology Program,China(No.JCYJ20160429115309834)the Science and Technology Development Plan Project of Shandong Province,China(Nos.2015GGX103016 and 2016GGX103032)
文摘Photoacoustic tomography（PAT） has the unique capability of visualizing optical absorption inside several centimeters-deep biological tissue with a high spatial resolution. However, single linear-array transducer-based PAT suffers from the limited-view challenge, and thus the synthetic aperture configuration is designed that still requires multichannel data acquisition hardware. Herein, a feasible synthetic aperture PAT based on compressed sensing reconstruction is proposed. Both the simulation and experimental results tested the theoretical model and validated that this approach can improve the image resolution and address the limited-view problem while preserving the target information with a fewer number of measurements.
