This study aimed to use computer simulation to describe the fluid dynamic characteristics in patients with obstructive sleep apnea syndrome（OSAS） and to evaluate the difference between during quiet respiration and t...This study aimed to use computer simulation to describe the fluid dynamic characteristics in patients with obstructive sleep apnea syndrome（OSAS） and to evaluate the difference between during quiet respiration and the Muller maneuver（MM）. Seven patients with OSAS were involved to perform computed tomographic（CT） scanning during quiet respiration and the MM. CT data in DICOM format were transformed into an anatomically three-dimensional computational fluid dynamics（CFD） model of the upper airway. The velocity magnitude, relative pressure, and flow distribution were obtained. Numerical simulation of airflow was performed to discuss how the MM affected airflow in the upper airway. To measure the discrepancy, the SPSS19.0 software package was utilized for statistic analysis. The results showed that the shape of the upper airway became narrower, and the pressure decreased during the MM. The minimal cross-sectional area（MCSA） of velopharynx was significantly decreased（P〈0.05） and the airflow velocity in MCSAs of velopharynx and glossopharynx significantly accelerated（P〈0.05） during the MM. This study demonstrated the possibility of CFD model combined with the MM for understanding pharyngeal aerodynamics in the pathophysiology of OSAS.展开更多
该研究旨在应用文献计量学,探索近十年中医药治疗阿尔茨海默病(AD)的国内外研究现状、热点和趋势。计算机检索Web of science、中国知网(CNKI),搜索2012年1月1日至2022年8月15日中医药治疗AD的相关文献,利用CiteSpace 6.1R2和VOSviewer ...该研究旨在应用文献计量学,探索近十年中医药治疗阿尔茨海默病(AD)的国内外研究现状、热点和趋势。计算机检索Web of science、中国知网(CNKI),搜索2012年1月1日至2022年8月15日中医药治疗AD的相关文献,利用CiteSpace 6.1R2和VOSviewer 1.6.15软件对作者、国家、机构、关键词、期刊等进行可视化分析。共纳入中文文献2254篇,英文文献545篇,年发文量总体呈波动上升趋势,发文量最多和中介中心性最大的国家均为中国,中、英文文献发文量最多的作者分别为孙国杰和WANG Qi,中、英文文献发文量最多的机构分别为湖北中医药大学和北京中医药大学,被引频次最高和中介中心性最高的英文期刊分别为《Journal of Ethnopharmacology》和《Neuroscience Letters》,中、英文文献的关键词分析显示中医药治疗AD研究主要集中在作用机制和治疗方法等方面,其中代谢组学、肠道菌群、氧化应激、tau蛋白过度磷酸化、β-淀粉样蛋白(Aβ)、炎症因子、自噬等为作用机制方面的研究重点,针刺、临床效果、肾虚痰瘀、通督启神等为临床研究方面的重点。该研究领域尚处于探索发展阶段,后续需加强各机构间有效的交流合作,开展更多中医药治疗AD的高质量基础研究,获得高级别循证医学证据,明确发病机制和方剂机制。展开更多
基金supported by grants from Shanghai College Young Teacher Training Program(No.shjdy029)Youth Projects of Shanghai Municipality Health and Family Planning Commission(No.20144Y0124)
文摘This study aimed to use computer simulation to describe the fluid dynamic characteristics in patients with obstructive sleep apnea syndrome（OSAS） and to evaluate the difference between during quiet respiration and the Muller maneuver（MM）. Seven patients with OSAS were involved to perform computed tomographic（CT） scanning during quiet respiration and the MM. CT data in DICOM format were transformed into an anatomically three-dimensional computational fluid dynamics（CFD） model of the upper airway. The velocity magnitude, relative pressure, and flow distribution were obtained. Numerical simulation of airflow was performed to discuss how the MM affected airflow in the upper airway. To measure the discrepancy, the SPSS19.0 software package was utilized for statistic analysis. The results showed that the shape of the upper airway became narrower, and the pressure decreased during the MM. The minimal cross-sectional area（MCSA） of velopharynx was significantly decreased（P〈0.05） and the airflow velocity in MCSAs of velopharynx and glossopharynx significantly accelerated（P〈0.05） during the MM. This study demonstrated the possibility of CFD model combined with the MM for understanding pharyngeal aerodynamics in the pathophysiology of OSAS.
文摘该研究旨在应用文献计量学,探索近十年中医药治疗阿尔茨海默病(AD)的国内外研究现状、热点和趋势。计算机检索Web of science、中国知网(CNKI),搜索2012年1月1日至2022年8月15日中医药治疗AD的相关文献,利用CiteSpace 6.1R2和VOSviewer 1.6.15软件对作者、国家、机构、关键词、期刊等进行可视化分析。共纳入中文文献2254篇,英文文献545篇,年发文量总体呈波动上升趋势,发文量最多和中介中心性最大的国家均为中国,中、英文文献发文量最多的作者分别为孙国杰和WANG Qi,中、英文文献发文量最多的机构分别为湖北中医药大学和北京中医药大学,被引频次最高和中介中心性最高的英文期刊分别为《Journal of Ethnopharmacology》和《Neuroscience Letters》,中、英文文献的关键词分析显示中医药治疗AD研究主要集中在作用机制和治疗方法等方面,其中代谢组学、肠道菌群、氧化应激、tau蛋白过度磷酸化、β-淀粉样蛋白(Aβ)、炎症因子、自噬等为作用机制方面的研究重点,针刺、临床效果、肾虚痰瘀、通督启神等为临床研究方面的重点。该研究领域尚处于探索发展阶段,后续需加强各机构间有效的交流合作,开展更多中医药治疗AD的高质量基础研究,获得高级别循证医学证据,明确发病机制和方剂机制。
