The structure-function relationship of insulin to be understood at three-dimensional level has already been a challenging problem since the elucidation of fine crystal structures of insulin. Of course, it is a better ...The structure-function relationship of insulin to be understood at three-dimensional level has already been a challenging problem since the elucidation of fine crystal structures of insulin. Of course, it is a better experimental approach to such a problem that certain insulin-receptor complexes were prepared and their structures were展开更多
Desheptapeptide (B24—30) insulin (abbreviated as DHPI), prepared by the removal of the C-terminal amino acids of the B chain of insulin using limited enzymatic method, is an inactive analog of insulin. It can be crys...Desheptapeptide (B24—30) insulin (abbreviated as DHPI), prepared by the removal of the C-terminal amino acids of the B chain of insulin using limited enzymatic method, is an inactive analog of insulin. It can be crystallized in 30% acetone at pH 5.7 in platelet form. DHPI occupied a special position in those analogs with the Ctermini of the B chain shortened. Considering that the solution of the crystal strue-展开更多
文摘The structure-function relationship of insulin to be understood at three-dimensional level has already been a challenging problem since the elucidation of fine crystal structures of insulin. Of course, it is a better experimental approach to such a problem that certain insulin-receptor complexes were prepared and their structures were
文摘Desheptapeptide (B24—30) insulin (abbreviated as DHPI), prepared by the removal of the C-terminal amino acids of the B chain of insulin using limited enzymatic method, is an inactive analog of insulin. It can be crystallized in 30% acetone at pH 5.7 in platelet form. DHPI occupied a special position in those analogs with the Ctermini of the B chain shortened. Considering that the solution of the crystal strue-
