耐药结核病是2035年实现全球终结结核病流行目标的巨大障碍。世界卫生组织(World Health Organization,WHO)倡导采用快速分子药物敏感性检测技术进行耐药结核病早期诊断,而覆盖全面可靠的耐药检测靶标是提高分子药物敏感性检测技术可靠...耐药结核病是2035年实现全球终结结核病流行目标的巨大障碍。世界卫生组织(World Health Organization,WHO)倡导采用快速分子药物敏感性检测技术进行耐药结核病早期诊断,而覆盖全面可靠的耐药检测靶标是提高分子药物敏感性检测技术可靠性的关键。WHO于2023年11月发布《结核分枝杆菌耐药相关基因突变目录(第2版)》,目的是基于更广泛的全球数据汇总形成更为全面准确的耐药相关基因突变目录,为开发与完善基于测序或其他方法的新型分子药物敏感性检测技术提供支持。本文对第2版目录相较于第1版目录在分析流程与耐药突变等内容的更新进行了详细的解读,并对未来目录完善的方向进行了展望。展开更多
The severe acute respiratory syndrome COVID-19 was discovered on December 31,2019 in China.Subsequently,many COVID-19 cases were reported in many other countries.However,some positive COVID-19 samples had been reporte...The severe acute respiratory syndrome COVID-19 was discovered on December 31,2019 in China.Subsequently,many COVID-19 cases were reported in many other countries.However,some positive COVID-19 samples had been reported earlier than those officially accepted by health authorities in other countries,such as France and Italy.Thus,it is of great importance to determine the place where SARS-CoV-2 was first transmitted to human.To this end,we analyze genomes of SARS-CoV-2 using k-mer natural vector method and compare the similarities of global SARS-CoV-2 genomes by a new natural metric.Because it is commonly accepted that SARS-CoV-2 is originated from bat coronavirus RaTG13,we only need to determine which SARS-CoV-2 genome sequence has the closest distance to bat coronavirus RaTG13 under our natural metric.From our analysis,SARS-CoV-2 most likely has already existed in other countries such as France,India,Netherland,England and United States before the outbreak at Wuhan,China.展开更多
文摘耐药结核病是2035年实现全球终结结核病流行目标的巨大障碍。世界卫生组织(World Health Organization,WHO)倡导采用快速分子药物敏感性检测技术进行耐药结核病早期诊断,而覆盖全面可靠的耐药检测靶标是提高分子药物敏感性检测技术可靠性的关键。WHO于2023年11月发布《结核分枝杆菌耐药相关基因突变目录(第2版)》,目的是基于更广泛的全球数据汇总形成更为全面准确的耐药相关基因突变目录,为开发与完善基于测序或其他方法的新型分子药物敏感性检测技术提供支持。本文对第2版目录相较于第1版目录在分析流程与耐药突变等内容的更新进行了详细的解读,并对未来目录完善的方向进行了展望。
基金supported by Tsinghua University Spring Breeze Fund(2020Z99CFY044)Tsinghua University start-up fundTsinghua University Education Foundation fund(042202008)。
文摘The severe acute respiratory syndrome COVID-19 was discovered on December 31,2019 in China.Subsequently,many COVID-19 cases were reported in many other countries.However,some positive COVID-19 samples had been reported earlier than those officially accepted by health authorities in other countries,such as France and Italy.Thus,it is of great importance to determine the place where SARS-CoV-2 was first transmitted to human.To this end,we analyze genomes of SARS-CoV-2 using k-mer natural vector method and compare the similarities of global SARS-CoV-2 genomes by a new natural metric.Because it is commonly accepted that SARS-CoV-2 is originated from bat coronavirus RaTG13,we only need to determine which SARS-CoV-2 genome sequence has the closest distance to bat coronavirus RaTG13 under our natural metric.From our analysis,SARS-CoV-2 most likely has already existed in other countries such as France,India,Netherland,England and United States before the outbreak at Wuhan,China.
