Kv1.5 potassium channel is reported as a potent and safe target for atrial fibrillation.CPUY11018 was proved it had moderate inhibition of Kv1.5.In order to improve the stability of CPUY11018,and investigate the struc...Kv1.5 potassium channel is reported as a potent and safe target for atrial fibrillation.CPUY11018 was proved it had moderate inhibition of Kv1.5.In order to improve the stability of CPUY11018,and investigate the structure-activity relationship,4 series of benzamide derivatives were synthesized and evaluated.Among them,8c is a most potent inhibitor of Kv1.5.展开更多
基金National High-tech R&D Program of China (863Program,Grant No. 2007AA02Z307)National Major Science andTechnology Project of China (Grant No. 2009ZX09103-088 and 2009ZX09501-003)
文摘Kv1.5 potassium channel is reported as a potent and safe target for atrial fibrillation.CPUY11018 was proved it had moderate inhibition of Kv1.5.In order to improve the stability of CPUY11018,and investigate the structure-activity relationship,4 series of benzamide derivatives were synthesized and evaluated.Among them,8c is a most potent inhibitor of Kv1.5.
