目的:探究重症肺炎患者血清APC,IL-18的表达及其与临床预后的相关性。方法:选取2022年1月~2024年1月我院收治的76例重症肺炎患者作为研究组,选择同期的76名到我院进行体检的健康人员作为对照组,全部研究对象均接受血清APC,IL-18指标的...目的:探究重症肺炎患者血清APC,IL-18的表达及其与临床预后的相关性。方法:选取2022年1月~2024年1月我院收治的76例重症肺炎患者作为研究组,选择同期的76名到我院进行体检的健康人员作为对照组,全部研究对象均接受血清APC,IL-18指标的检测。结果:研究组的血清APC水平更低(P Objective: To investigate the expression of serum APC and IL-18 in patients with severe pneumonia and their correlation with clinical prognosis. Method: 76 severe pneumonia patients admitted to our hospital from January 2022 to January 2024 were selected as the study group, and 76 healthy individuals who came to our hospital for physical examination during the same period were selected as the control group. All study subjects underwent serum APC and IL-18 index detection. Result: The serum APC level in the study group was lower (P < 0.05), and the IL-18 level in the study group was higher (P < 0.05);The regression analysis results showed that the levels of serum IL-18 and APC were related to the clinical prognosis of patients with severe pneumonia (P < 0.05);There is a significant positive correlation (P < 0.05) between different prognostic outcomes and serum IL-18 levels, and a significant negative correlation (P < 0.05) between different prognostic outcomes and serum APC levels. Conclusion: Compared with healthy individuals, patients with severe pneumonia show significant changes in serum APC and IL-18 indicators, which also have a significant impact on the prognosis of severe pneumonia patients, providing important reference for subsequent clinical diagnosis and treatment.展开更多
X-盒结合蛋白(X-box binding protein 1,XBP1)是碱性亮氨酸拉链结构蛋白,在脑缺血引起的内质网应激反应中扮演着重要角色。XBP1在非内质网应激时以未剪接的X-盒结合蛋白1(X-box binding protein 1-unspliced,XBP1-u)的形式表达,在内质...X-盒结合蛋白(X-box binding protein 1,XBP1)是碱性亮氨酸拉链结构蛋白,在脑缺血引起的内质网应激反应中扮演着重要角色。XBP1在非内质网应激时以未剪接的X-盒结合蛋白1(X-box binding protein 1-unspliced,XBP1-u)的形式表达,在内质网应激期间表现为剪接的X-盒结合蛋白(X-box binding protein 1-spliced,XBP1-s)的形式。为了充分了解XBP1,该文将从XBP1的两种异构体的结构、分布、定位以及病理生理功能等方面进行综述,并重点探讨XBP1-s在脑缺血后激活氧连-N-乙酰葡萄胺修饰和葡萄糖调节蛋白-78表达以减少氧化应激损伤、促进缺血组织中的内皮细胞增殖保护脑微血管内皮细胞损伤以及调节细胞焦亡等方面的作用。展开更多
文摘目的:探究重症肺炎患者血清APC,IL-18的表达及其与临床预后的相关性。方法:选取2022年1月~2024年1月我院收治的76例重症肺炎患者作为研究组,选择同期的76名到我院进行体检的健康人员作为对照组,全部研究对象均接受血清APC,IL-18指标的检测。结果:研究组的血清APC水平更低(P Objective: To investigate the expression of serum APC and IL-18 in patients with severe pneumonia and their correlation with clinical prognosis. Method: 76 severe pneumonia patients admitted to our hospital from January 2022 to January 2024 were selected as the study group, and 76 healthy individuals who came to our hospital for physical examination during the same period were selected as the control group. All study subjects underwent serum APC and IL-18 index detection. Result: The serum APC level in the study group was lower (P < 0.05), and the IL-18 level in the study group was higher (P < 0.05);The regression analysis results showed that the levels of serum IL-18 and APC were related to the clinical prognosis of patients with severe pneumonia (P < 0.05);There is a significant positive correlation (P < 0.05) between different prognostic outcomes and serum IL-18 levels, and a significant negative correlation (P < 0.05) between different prognostic outcomes and serum APC levels. Conclusion: Compared with healthy individuals, patients with severe pneumonia show significant changes in serum APC and IL-18 indicators, which also have a significant impact on the prognosis of severe pneumonia patients, providing important reference for subsequent clinical diagnosis and treatment.
文摘X-盒结合蛋白(X-box binding protein 1,XBP1)是碱性亮氨酸拉链结构蛋白,在脑缺血引起的内质网应激反应中扮演着重要角色。XBP1在非内质网应激时以未剪接的X-盒结合蛋白1(X-box binding protein 1-unspliced,XBP1-u)的形式表达,在内质网应激期间表现为剪接的X-盒结合蛋白(X-box binding protein 1-spliced,XBP1-s)的形式。为了充分了解XBP1,该文将从XBP1的两种异构体的结构、分布、定位以及病理生理功能等方面进行综述,并重点探讨XBP1-s在脑缺血后激活氧连-N-乙酰葡萄胺修饰和葡萄糖调节蛋白-78表达以减少氧化应激损伤、促进缺血组织中的内皮细胞增殖保护脑微血管内皮细胞损伤以及调节细胞焦亡等方面的作用。
