目的:构建基于上皮间质相互作用蛋白1(epithelial-stromal interaction protein 1,EPSTI1)预后列线图预测肾透明细胞癌的预后。方法:回顾性分析2012年1月至2015年12月于福建医科大学附属第一医院221例接受手术治疗的肾透明细胞癌患者和T...目的:构建基于上皮间质相互作用蛋白1(epithelial-stromal interaction protein 1,EPSTI1)预后列线图预测肾透明细胞癌的预后。方法:回顾性分析2012年1月至2015年12月于福建医科大学附属第一医院221例接受手术治疗的肾透明细胞癌患者和TCGA数据库中533例肾透明细胞癌患者数据,对癌旁正常组织和癌组织标本进行免疫组织化学(immunohistochemistry,IHC)染色,分析EPSTI1的表达差异及与临床病理特征的相关性。对EPSTI1高表达与低表达患者的总生存期(overall survival,OS)和无病生存期(disease-free survival,DFS)进行Kaplan-Meier生存分析,采用单因素和多因素Cox比例风险模型分析OS的预后因素,进一步构建列线图模型并验证。结果:与癌旁正常肾组织比较,肾透明细胞癌组织中EPSTI1的IHC评分和m RNA表达水平均显著高于正常组织(均P<0.001),且在高T分期的癌组织中表达更高(P=0.036,P=0.006);EPSTI1蛋白表达与肿瘤最大径、TNM分期相关(P=0.002,P=0.032);EPSTI1低表达组OS、DFS均优于高表达组(P=0.046,P=0.003,P=0.001);单因素和多因素Cox回归分析结果显示,EPSTI1蛋白高表达、WHO/ISUP分级、AJCC/TNM分期是影响肾透明细胞癌患者预后不良的独立危险因素(P=0.009,P=0.039,P<0.001);基于上述变量构建的预后列线图模型对患者5年OS预测能力优于AJCC/TNM分期,校准曲线显示模型预测值与实际值间具有良好的一致性。结论:基于EPSTI1、AJCC/TNM分期和WHO/ISUP分级建立的列线图模型对肾透明细胞癌预后具有较强的预测能力。展开更多
文章以上海市谈家桥路旧住房拆除重建工程基坑为研究案例,利用Midas GTX NX软件构建3D模型,对比分析了有无混凝土支撑轴力伺服两种情况下的基坑开挖数值模拟结果,并结合现场实测数据进行了深入研究。研究结果显示,采用混凝土支撑轴力伺...文章以上海市谈家桥路旧住房拆除重建工程基坑为研究案例,利用Midas GTX NX软件构建3D模型,对比分析了有无混凝土支撑轴力伺服两种情况下的基坑开挖数值模拟结果,并结合现场实测数据进行了深入研究。研究结果显示,采用混凝土支撑轴力伺服技术能够显著减少基坑变形,满足了基坑微变形控制要求,对敏感区周边环境保护具有重要作用;基于实测数据修正的基坑开挖模型可精确模拟单一施工要素变化后的变形情况,为基坑变形机理研究和预测提供了重要参考。This article takes the foundation pit of the old housing demolition and reconstruction project on Tanjiaqiao Road in Shanghai as a research case, constructs a 3D model using Midas GTX NX software, compares and analyzes the numerical simulation results of foundation pit excavation under two conditions: with and without concrete support axial force servo, and conducts in-depth research based on on-site measured data. The research results show that the use of concrete support axial force servo technology can significantly reduce the deformation of foundation pits, meet the requirements of micro deformation control of foundation pits, and play an important role in protecting the surrounding environment of sensitive areas;The excavation model of foundation pits modified based on measured data can accurately simulate the deformation situation after a single construction element changes, providing an important reference for the research and prediction of foundation pit deformation mechanisms.展开更多
文摘文章以上海市谈家桥路旧住房拆除重建工程基坑为研究案例,利用Midas GTX NX软件构建3D模型,对比分析了有无混凝土支撑轴力伺服两种情况下的基坑开挖数值模拟结果,并结合现场实测数据进行了深入研究。研究结果显示,采用混凝土支撑轴力伺服技术能够显著减少基坑变形,满足了基坑微变形控制要求,对敏感区周边环境保护具有重要作用;基于实测数据修正的基坑开挖模型可精确模拟单一施工要素变化后的变形情况,为基坑变形机理研究和预测提供了重要参考。This article takes the foundation pit of the old housing demolition and reconstruction project on Tanjiaqiao Road in Shanghai as a research case, constructs a 3D model using Midas GTX NX software, compares and analyzes the numerical simulation results of foundation pit excavation under two conditions: with and without concrete support axial force servo, and conducts in-depth research based on on-site measured data. The research results show that the use of concrete support axial force servo technology can significantly reduce the deformation of foundation pits, meet the requirements of micro deformation control of foundation pits, and play an important role in protecting the surrounding environment of sensitive areas;The excavation model of foundation pits modified based on measured data can accurately simulate the deformation situation after a single construction element changes, providing an important reference for the research and prediction of foundation pit deformation mechanisms.
