The analgesic effect of dynorphin (dyn) at the spinal level was first reported in 1982 by Piercey et al. in mice and by Han et al. in rats. These findings have been verified by some investigators using intrathecal inj...The analgesic effect of dynorphin (dyn) at the spinal level was first reported in 1982 by Piercey et al. in mice and by Han et al. in rats. These findings have been verified by some investigators using intrathecal injection of dyn, but not with kappa receptor agonist USO, 488. In 1982, a new [Leu] enkephalin C terminal extended peptide dyn B (rimorphin) was found and the original 17-residue peptide dyn was re-展开更多
The finding that acupuncture analgesia could be blocked by naloxone provided ample evidence for the participation of endogenous opioids in mediating the effect of acupuncture analgesia. However it gives no clue as to ...The finding that acupuncture analgesia could be blocked by naloxone provided ample evidence for the participation of endogenous opioids in mediating the effect of acupuncture analgesia. However it gives no clue as to which member of the opioid peptides is actually involved.展开更多
It has been known in the clinical practice that the therapeutic effect of acupuncture varies widely in different individuals, although the acupuncturist is using the same acupoint and the same mode of needle manipulat...It has been known in the clinical practice that the therapeutic effect of acupuncture varies widely in different individuals, although the acupuncturist is using the same acupoint and the same mode of needle manipulation. In addition, the effect of展开更多
Sabstance P (SP) in brain has been shown to produce analgesia although its mechanism of action has not been fully understood. In the present study, microinjection was made by an injection tube of o.d. 0.35 mm via ster...Sabstance P (SP) in brain has been shown to produce analgesia although its mechanism of action has not been fully understood. In the present study, microinjection was made by an injection tube of o.d. 0.35 mm via stereotaxically implanted cannula directed to periaqueduc-展开更多
文摘The analgesic effect of dynorphin (dyn) at the spinal level was first reported in 1982 by Piercey et al. in mice and by Han et al. in rats. These findings have been verified by some investigators using intrathecal injection of dyn, but not with kappa receptor agonist USO, 488. In 1982, a new [Leu] enkephalin C terminal extended peptide dyn B (rimorphin) was found and the original 17-residue peptide dyn was re-
文摘The finding that acupuncture analgesia could be blocked by naloxone provided ample evidence for the participation of endogenous opioids in mediating the effect of acupuncture analgesia. However it gives no clue as to which member of the opioid peptides is actually involved.
文摘It has been known in the clinical practice that the therapeutic effect of acupuncture varies widely in different individuals, although the acupuncturist is using the same acupoint and the same mode of needle manipulation. In addition, the effect of
文摘Sabstance P (SP) in brain has been shown to produce analgesia although its mechanism of action has not been fully understood. In the present study, microinjection was made by an injection tube of o.d. 0.35 mm via stereotaxically implanted cannula directed to periaqueduc-
