目的:基于数据挖掘方法探索慢性乙型肝炎肝郁脾虚证的用药规律。方法:系统检索自建库至2024年5月期间收录于中国知网、维普、万方及中国生物医学文献库中关于治疗慢性乙型肝炎肝郁脾虚证的相关文献。同时通过人工检索方式,搜集并筛选200...目的:基于数据挖掘方法探索慢性乙型肝炎肝郁脾虚证的用药规律。方法:系统检索自建库至2024年5月期间收录于中国知网、维普、万方及中国生物医学文献库中关于治疗慢性乙型肝炎肝郁脾虚证的相关文献。同时通过人工检索方式,搜集并筛选2004年至2024年间关于探讨慢性乙型肝炎中肝郁脾虚证相关论述的书目。构建符合条件的文献与书目数据库,运用中医传承系统软件管理,通过频数、关联规则及聚类分析等手段,探讨主要药物及其组合的规律性。结果:在121个针对慢性乙型肝炎肝郁脾虚证的中药复方中,涉及147种药物,总使用次数达1272次。其中,14种药物的使用超过20次,以柴胡、白术、甘草、茯苓、白芍最为常见。高频药物组合包括甘草–柴胡、柴胡–茯苓及白术–甘草–柴胡。药物效能上,多侧重于补虚、清热、理气,药味以苦、甘为主,药性则偏寒、温。通过关联规则分析,提炼出23条药物组合规则,聚类分析进一步形成了9个新的核心处方。结论:通过数据库及查阅相关书目对文献组方用药挖掘处理可归纳得出中医药治疗肝郁脾虚型慢性乙型肝炎的新组方、药对、核心中药及治则治法等,并深入探讨了慢性乙型肝炎肝郁脾虚证的用药规律。Objective: To explore the medication pattern of chronic hepatitis B with liver depression and spleen deficiency based on data mining method. Methods: A systematic search was conducted to identify relevant literature on the treatment of liver depression and spleen deficiency in chronic hepatitis B from May 2024 to May 2024 in China Knowledge Network, Wipro, Wanfang, and China Biomedical Literature Database. Also, bibliographies on discussions related to liver depression and spleen deficiency syndrome in chronic hepatitis B between 2004 and 2024 were collected and screened by manual search. A database of eligible literature and bibliographies was constructed and managed by using the Chinese Medicine Heritage System software to explore the regularity of the main drugs and their combinations by means of frequency counts, association rules and cluster analysis. Results: Among 121 TCM compound prescriptions for chronic hepatitis B with liver depression and spleen deficiency, 147 drugs were involved, with a total number of 1272 uses. Among them, 14 drugs were used more than 20 times, with chai hu, atractylodes macrocephala, glycyrrhiza glabra, poria, and paeonia lactiflora being the most common. High-frequency drug combinations included licorice-chai hu, chai hu-poria, and atractylodes-glycyrrhiza glabra-chai hu. In terms of drug efficacy, most of them focused on tonifying deficiency, clearing heat and regulating qi, and the flavors of the drugs were mainly bitter and sweet, while the properties of the drugs were cold and warm. Through the analysis of association rules, 23 drug combination rules were extracted, and cluster analysis further formed 9 new core prescriptions. Conclusıon: The new formulas, drug pairs, core Chinese medicines and treatment rules and treatments for chronic hepatitis B in TCM treatment of liver-depression and spleen-deficiency can be summarized through the database and bibliographic review of the literature on medication mining and processing, and the rules and treatments for chronic hepatitis B with liver-depression and spleen-deficiency were also discussed in depth.展开更多
文摘目的:基于数据挖掘方法探索慢性乙型肝炎肝郁脾虚证的用药规律。方法:系统检索自建库至2024年5月期间收录于中国知网、维普、万方及中国生物医学文献库中关于治疗慢性乙型肝炎肝郁脾虚证的相关文献。同时通过人工检索方式,搜集并筛选2004年至2024年间关于探讨慢性乙型肝炎中肝郁脾虚证相关论述的书目。构建符合条件的文献与书目数据库,运用中医传承系统软件管理,通过频数、关联规则及聚类分析等手段,探讨主要药物及其组合的规律性。结果:在121个针对慢性乙型肝炎肝郁脾虚证的中药复方中,涉及147种药物,总使用次数达1272次。其中,14种药物的使用超过20次,以柴胡、白术、甘草、茯苓、白芍最为常见。高频药物组合包括甘草–柴胡、柴胡–茯苓及白术–甘草–柴胡。药物效能上,多侧重于补虚、清热、理气,药味以苦、甘为主,药性则偏寒、温。通过关联规则分析,提炼出23条药物组合规则,聚类分析进一步形成了9个新的核心处方。结论:通过数据库及查阅相关书目对文献组方用药挖掘处理可归纳得出中医药治疗肝郁脾虚型慢性乙型肝炎的新组方、药对、核心中药及治则治法等,并深入探讨了慢性乙型肝炎肝郁脾虚证的用药规律。Objective: To explore the medication pattern of chronic hepatitis B with liver depression and spleen deficiency based on data mining method. Methods: A systematic search was conducted to identify relevant literature on the treatment of liver depression and spleen deficiency in chronic hepatitis B from May 2024 to May 2024 in China Knowledge Network, Wipro, Wanfang, and China Biomedical Literature Database. Also, bibliographies on discussions related to liver depression and spleen deficiency syndrome in chronic hepatitis B between 2004 and 2024 were collected and screened by manual search. A database of eligible literature and bibliographies was constructed and managed by using the Chinese Medicine Heritage System software to explore the regularity of the main drugs and their combinations by means of frequency counts, association rules and cluster analysis. Results: Among 121 TCM compound prescriptions for chronic hepatitis B with liver depression and spleen deficiency, 147 drugs were involved, with a total number of 1272 uses. Among them, 14 drugs were used more than 20 times, with chai hu, atractylodes macrocephala, glycyrrhiza glabra, poria, and paeonia lactiflora being the most common. High-frequency drug combinations included licorice-chai hu, chai hu-poria, and atractylodes-glycyrrhiza glabra-chai hu. In terms of drug efficacy, most of them focused on tonifying deficiency, clearing heat and regulating qi, and the flavors of the drugs were mainly bitter and sweet, while the properties of the drugs were cold and warm. Through the analysis of association rules, 23 drug combination rules were extracted, and cluster analysis further formed 9 new core prescriptions. Conclusıon: The new formulas, drug pairs, core Chinese medicines and treatment rules and treatments for chronic hepatitis B in TCM treatment of liver-depression and spleen-deficiency can be summarized through the database and bibliographic review of the literature on medication mining and processing, and the rules and treatments for chronic hepatitis B with liver-depression and spleen-deficiency were also discussed in depth.
