目的:研究达格列净、二甲双胍治疗初诊2型糖尿病(diabetes mellitus type 2,T2DM)患者对糖脂代谢、胰岛素抵抗的影响。方法:研究对象以2019年7月至2023年7月于周口市中医院初诊的T2DM患者120例,以随机数字表法分为观察组及对照组各60例...目的:研究达格列净、二甲双胍治疗初诊2型糖尿病(diabetes mellitus type 2,T2DM)患者对糖脂代谢、胰岛素抵抗的影响。方法:研究对象以2019年7月至2023年7月于周口市中医院初诊的T2DM患者120例,以随机数字表法分为观察组及对照组各60例,比较两组患者血糖指标、血脂指标、胰岛素功能。结果:治疗后,观察组患者餐后2h血糖指标、空腹血糖指标、糖化血红蛋白、总胆固醇(serum total cholesterol,TC)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、甘油三酯(triglycerides,TG)、空腹胰岛素、餐后30min胰岛素、餐后60min胰岛素、餐后2h胰岛素、餐后3h胰岛素均较对照组低(P<0.05);观察组患者高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)水平较对照组高(P<0.05)。结论:采用达格列净联合二甲双胍治疗可促进初诊T2DM患者糖脂代谢的改善,并改善胰岛素分泌,且疗效较好。展开更多
Aim To screen the optimum macroporous resin and conditions for the isolation and purification of flavonoids from Radix Puerariae. Methods The static and dynamic adsorption/desorption methods were used, and the separat...Aim To screen the optimum macroporous resin and conditions for the isolation and purification of flavonoids from Radix Puerariae. Methods The static and dynamic adsorption/desorption methods were used, and the separation and purification process was evaluated by measuring the concentration of total flavonoid in the fractions with UV spectrophotometer. Results The SP70 macroporous resin was the most effective compared with other macroporous resins. The optimum conditions were screened, which were 0.5 g· mL^- 1 corresponding to crude drug for concentration of extract, pH 5 - 6, and appended 60 times the volume of the resin bed (BV) with the adsorption speed 2 BV·h^-1, and the volume of aq. 70% (V/V) ethanol as eluant was 5 BV with desorption speed 2 BV·h^-1. By this method, the final contents of total flavonoids exceeded 80%. Conclusion The SP70 macroporous resin is the most effective one for large-scale isolation and purification of flavonoids from Radix Pueraria, which meets industrial needs.展开更多
文摘目的:研究达格列净、二甲双胍治疗初诊2型糖尿病(diabetes mellitus type 2,T2DM)患者对糖脂代谢、胰岛素抵抗的影响。方法:研究对象以2019年7月至2023年7月于周口市中医院初诊的T2DM患者120例,以随机数字表法分为观察组及对照组各60例,比较两组患者血糖指标、血脂指标、胰岛素功能。结果:治疗后,观察组患者餐后2h血糖指标、空腹血糖指标、糖化血红蛋白、总胆固醇(serum total cholesterol,TC)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、甘油三酯(triglycerides,TG)、空腹胰岛素、餐后30min胰岛素、餐后60min胰岛素、餐后2h胰岛素、餐后3h胰岛素均较对照组低(P<0.05);观察组患者高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)水平较对照组高(P<0.05)。结论:采用达格列净联合二甲双胍治疗可促进初诊T2DM患者糖脂代谢的改善,并改善胰岛素分泌,且疗效较好。
基金Science and Technology Committee of Chongqing inChina(CSTC.2004BB5122).
文摘Aim To screen the optimum macroporous resin and conditions for the isolation and purification of flavonoids from Radix Puerariae. Methods The static and dynamic adsorption/desorption methods were used, and the separation and purification process was evaluated by measuring the concentration of total flavonoid in the fractions with UV spectrophotometer. Results The SP70 macroporous resin was the most effective compared with other macroporous resins. The optimum conditions were screened, which were 0.5 g· mL^- 1 corresponding to crude drug for concentration of extract, pH 5 - 6, and appended 60 times the volume of the resin bed (BV) with the adsorption speed 2 BV·h^-1, and the volume of aq. 70% (V/V) ethanol as eluant was 5 BV with desorption speed 2 BV·h^-1. By this method, the final contents of total flavonoids exceeded 80%. Conclusion The SP70 macroporous resin is the most effective one for large-scale isolation and purification of flavonoids from Radix Pueraria, which meets industrial needs.