功能化离子液体催化合成柠檬酸三丁酯的研究

Tri-butyl citrate(TBC) is synthesized by using several kinds of ionic liquids as catalyst.The results show that the functionalized Brnsted acid ionic liquid([TEA-PS]) is the best catalytic among them;and use it as catalyst to optimize the reaction conditions:the proportion of reaction materiel is 1∶3.8(citric acid∶1-butanol);reaction temperature is 130℃;reaction time is 3.5h;cat./citric acid=15∶100(wt);the conversion of citric acid up to 99%.After simply separated from the products and treated with diethyl ether,the ionic liquid could be reused 8 times without noticeably decreasing in the catalytic activity.Therefore,an environmental friendly approach for synthesis of TBC could be provided with the ionic liquid as catalysts.

功能化离子液体催化邻苯二甲酸二辛酯的合成及其工艺

利用功能化酸性离子液体催化合成邻苯二甲酸二辛酯(DOP),结果表明,其催化效果比非功能化的中性离子液体好,催化剂循环使用率高,其中,功能化酸性离子液体[HSO3-PMIM][HSO4]的催化活性最好,并确定了用其催化合成DOP的优化工艺条件:酐醇物质的量比1∶3,反应温度140℃,反应时间2.5h,离子液体最佳用量为反应体系总质量的15%,环己烷作带水剂,此条件下,酯化率可达98.6%以上。

抗疟药本芴醇的合成新工艺

目的:设计抗疟药本芴醇的合成新工艺。方法:以工业芴为原料,在二氧化锰存在下,用冰醋酸作溶剂,通氯化氢气体法制得2,7-二氯芴;以无水三氯化铝为催化剂,在二氯甲烷中用氯乙酰氯进行酰化反应得到2,7-二氯-4-氯乙酰芴;再将还原、胺基化和缩合反应通过"一锅法"完成,制得本芴醇。结果与结论:该工艺路线的本芴醇总收率以芴计达40%以上,且后处理步骤较少,操作简单,中间过程容易控制,具有较大的实用价值。该工艺路线与原路线相比更适用于工业化生产。