背景:慢性病的发病率高、危险性大,是全球性公共健康首要问题。糖尿病宛如“慢性癌症”,是由饮食、环境、药物、遗传等因素导致的,体内胰岛素分泌相对或者绝对不足而出现的血糖代谢紊乱。常见以II型糖尿病为主,并发症可导致患者心肌梗...背景:慢性病的发病率高、危险性大,是全球性公共健康首要问题。糖尿病宛如“慢性癌症”,是由饮食、环境、药物、遗传等因素导致的,体内胰岛素分泌相对或者绝对不足而出现的血糖代谢紊乱。常见以II型糖尿病为主,并发症可导致患者心肌梗塞、脑溢血、失明、肾功能衰竭和下肢截肢等严重后果,是影响人类健康和寿命的主要危险因素。目的:总结II型糖尿病大血管病变发病生物标志物的研究进展,以期为II型糖尿病大血管病变及其所引起的心脑血管疾病的防治提供新靶点。方法:以“macrovascular disease in type 2 diabetes mellitus,pathogenesis”为英文检索词,以“II型糖尿病并发大血管病变,发病机制”为中文检索词,应用计算机检索PubMed、Medline、中国知网和万方数据库发表的相关文献,最终纳入文献59篇进行归纳分析。结果与结论:II型糖尿病大血管病变是由多种因素共同作用导致的复杂疾病。近年来,大量实验室和临床研究表明,其发生发展主要与非编码RNA、外泌体、炎性小体、活化T细胞核因子、骨形态发生蛋白等生物标志物有关,上述生物标志物有望成为II型糖尿病大血管病变新靶点。展开更多
目的:探究拉萨和咸阳导致H型高血压的影响因素,为其防治提供依据。方法:从拉萨三级医院随机抽取102名住院患者,咸阳三级医院随机抽取155名住院患者,采用问卷调查的形式,从民族、年龄、性别、血浆半胱氨酸水平、吸烟和饮酒的程度、精神...目的:探究拉萨和咸阳导致H型高血压的影响因素,为其防治提供依据。方法:从拉萨三级医院随机抽取102名住院患者,咸阳三级医院随机抽取155名住院患者,采用问卷调查的形式,从民族、年龄、性别、血浆半胱氨酸水平、吸烟和饮酒的程度、精神状态及睡眠情况八个方面进行统计,采用SPSS25.0软件进行多因素Logistic回归分析H型高血压的影响因素。结果:西藏拉萨的调查数据中,男性H型高血压患病率为46.84%,女性为78.26%;陕西咸阳的调查数据中,男性H型高血压患病率为56.79%,女性为32.43%。多因素Logistic回归模型分析结果显示,西藏拉萨H型高血压患者的相关危险因素中年龄和精神状态有显著的统计学意义;而陕西咸阳H型高血压患者的相关危险因素中性别、精神状态及睡眠情况有显著的统计学意义。结论:西藏拉萨H型高血压患者的独立危险因素包括年龄(≥50岁)、精神状态;而陕西咸阳H型高血压患者的独立危险因素包括性别、精神状态及睡眠情况。 Objective: To explore the influencingfactors of H-type hypertension in Lhasa and Xianyang, and provide proof for itsprevention and treatment. Methods: One hundred and two hospitalized patientswere randomly selected from Lhasa tertiary Hospital, and 155 inpatients wererandomly selected from Xianyang tertiary Hospital, using questionnaire survey,from nationality, age, gender, plasma cysteine level, degree of smoking and alcoholdrinking, mental state and sleep, using SPSS25.0software for multivariate Logistic regression to analyze the influencingfactors of H hypertension. Results: Survey data in Lhasa, Tibet showed that the prevalence of H-type hypertensionin men was 46.84% and that in women was 78.26%. Survey data in Xianyang,Shaanxi showed that the prevalence of H-type hypertension in men was 56.79% and that in women was 32.43%. Multiple logisticregression model analysis showed that age and mental state hadsignificant statistical significance among the risk factors of H-typehypertension patients in Lhasa, Tibet;the gender, mental state and sleep qualityof H-type hypertension patients in Xianyang, Shaanxi had significant statistical significance. Conclusion: The independentrisk factors of H-type hypertension patients in Lhasa, Tibet includedage (≥50 years) and mental state;the independent risk factors of h-typehypertension patients in Xianyang, Shaanxi included gender, mental state andsleep quality.展开更多
文摘背景:慢性病的发病率高、危险性大,是全球性公共健康首要问题。糖尿病宛如“慢性癌症”,是由饮食、环境、药物、遗传等因素导致的,体内胰岛素分泌相对或者绝对不足而出现的血糖代谢紊乱。常见以II型糖尿病为主,并发症可导致患者心肌梗塞、脑溢血、失明、肾功能衰竭和下肢截肢等严重后果,是影响人类健康和寿命的主要危险因素。目的:总结II型糖尿病大血管病变发病生物标志物的研究进展,以期为II型糖尿病大血管病变及其所引起的心脑血管疾病的防治提供新靶点。方法:以“macrovascular disease in type 2 diabetes mellitus,pathogenesis”为英文检索词,以“II型糖尿病并发大血管病变,发病机制”为中文检索词,应用计算机检索PubMed、Medline、中国知网和万方数据库发表的相关文献,最终纳入文献59篇进行归纳分析。结果与结论:II型糖尿病大血管病变是由多种因素共同作用导致的复杂疾病。近年来,大量实验室和临床研究表明,其发生发展主要与非编码RNA、外泌体、炎性小体、活化T细胞核因子、骨形态发生蛋白等生物标志物有关,上述生物标志物有望成为II型糖尿病大血管病变新靶点。
文摘目的:探究拉萨和咸阳导致H型高血压的影响因素,为其防治提供依据。方法:从拉萨三级医院随机抽取102名住院患者,咸阳三级医院随机抽取155名住院患者,采用问卷调查的形式,从民族、年龄、性别、血浆半胱氨酸水平、吸烟和饮酒的程度、精神状态及睡眠情况八个方面进行统计,采用SPSS25.0软件进行多因素Logistic回归分析H型高血压的影响因素。结果:西藏拉萨的调查数据中,男性H型高血压患病率为46.84%,女性为78.26%;陕西咸阳的调查数据中,男性H型高血压患病率为56.79%,女性为32.43%。多因素Logistic回归模型分析结果显示,西藏拉萨H型高血压患者的相关危险因素中年龄和精神状态有显著的统计学意义;而陕西咸阳H型高血压患者的相关危险因素中性别、精神状态及睡眠情况有显著的统计学意义。结论:西藏拉萨H型高血压患者的独立危险因素包括年龄(≥50岁)、精神状态;而陕西咸阳H型高血压患者的独立危险因素包括性别、精神状态及睡眠情况。 Objective: To explore the influencingfactors of H-type hypertension in Lhasa and Xianyang, and provide proof for itsprevention and treatment. Methods: One hundred and two hospitalized patientswere randomly selected from Lhasa tertiary Hospital, and 155 inpatients wererandomly selected from Xianyang tertiary Hospital, using questionnaire survey,from nationality, age, gender, plasma cysteine level, degree of smoking and alcoholdrinking, mental state and sleep, using SPSS25.0software for multivariate Logistic regression to analyze the influencingfactors of H hypertension. Results: Survey data in Lhasa, Tibet showed that the prevalence of H-type hypertensionin men was 46.84% and that in women was 78.26%. Survey data in Xianyang,Shaanxi showed that the prevalence of H-type hypertension in men was 56.79% and that in women was 32.43%. Multiple logisticregression model analysis showed that age and mental state hadsignificant statistical significance among the risk factors of H-typehypertension patients in Lhasa, Tibet;the gender, mental state and sleep qualityof H-type hypertension patients in Xianyang, Shaanxi had significant statistical significance. Conclusion: The independentrisk factors of H-type hypertension patients in Lhasa, Tibet includedage (≥50 years) and mental state;the independent risk factors of h-typehypertension patients in Xianyang, Shaanxi included gender, mental state andsleep quality.
