A facile synthesis of a series of new quinoline-8-carbaldehyde compounds, namely 8-formyl-2- (phenoxymethyl)quinoline-3-carboxylic acids (4a--4h) and 13-oxo-6,13-dihydro[1]benzoxepino[3,4-b]quinoline- 8-carbaldehy...A facile synthesis of a series of new quinoline-8-carbaldehyde compounds, namely 8-formyl-2- (phenoxymethyl)quinoline-3-carboxylic acids (4a--4h) and 13-oxo-6,13-dihydro[1]benzoxepino[3,4-b]quinoline- 8-carbaldehyde (5a--5g) is described, involving the one-pot synthesis reaction of ethyl 2-(chloromethyl)-8- formylquinoline-3-carboxylate (3) with substituted phenols followed by the intramolecular cyclization reaction via the treatment with polyphosphoric acid (PPA). Quinoline-8-carbaldehydes 4a--4h and 5a--5g are novel and their structures were supported by IR, IH NMR, 13C NMR, MS and elemental analysis.展开更多
文摘A facile synthesis of a series of new quinoline-8-carbaldehyde compounds, namely 8-formyl-2- (phenoxymethyl)quinoline-3-carboxylic acids (4a--4h) and 13-oxo-6,13-dihydro[1]benzoxepino[3,4-b]quinoline- 8-carbaldehyde (5a--5g) is described, involving the one-pot synthesis reaction of ethyl 2-(chloromethyl)-8- formylquinoline-3-carboxylate (3) with substituted phenols followed by the intramolecular cyclization reaction via the treatment with polyphosphoric acid (PPA). Quinoline-8-carbaldehydes 4a--4h and 5a--5g are novel and their structures were supported by IR, IH NMR, 13C NMR, MS and elemental analysis.