目的:基于数据挖掘分析赵珂主任治疗薄型子宫内膜(thin endometrium, TE)致月经过少的用药规律。方法:收集赵珂主任门诊的215首TE致月经过少的中药处方信息,对组成药物进行数据整理及科学性分析,录入Excel建立数据库,并运用SPSS软件建...目的:基于数据挖掘分析赵珂主任治疗薄型子宫内膜(thin endometrium, TE)致月经过少的用药规律。方法:收集赵珂主任门诊的215首TE致月经过少的中药处方信息,对组成药物进行数据整理及科学性分析,录入Excel建立数据库,并运用SPSS软件建立的复杂网络系统,分析TE致月经量减少处方中的高频药物和配伍方法原理。结果:共纳入215首中药方剂,包括了165味中药,其中使用频次 ≥ 100的中药有13味,依次为菟丝子、黄精、山茱萸、熟地黄等。中药四气以温性为主;五味以甘、苦、辛为主;归经以肝、脾、肾经为主。关联规则及复杂网络图得出关联性强的药物组合为菟丝子→续断,菟丝子→鹿角霜,山茱萸→太子参、丹参。聚类分析可将药物分为3类,第1类为补肾类,第2类为养血健脾疏肝类,第3类为活血化瘀类。结论:赵珂主任治疗TE致月经过少以补肾调经为基本治则,养血活血,顾护脾胃,通补兼施。从而达到病机治本、病症治标的疗效。Objective: To analyze the medication patterns of Director Zhao Ke in treating hypomenorrhea due to thin endometrium (TE) based on data mining. Methods: Information from 215 Chinese herbal prescriptions for TE-induced hypomenorrhea from Director Zhao Ke’s outpatient clinic was collected. The constituent herbs were organized and analyzed scientifically, entered into an Excel database, and a complex network system established using SPSS software was utilized to analyze the high-frequency herbs and principles of compatibility in prescriptions for TE-induced hypomenorrhea. Results: A total of 215 Chinese herbal formulas were included, comprising 165 Chinese herbs. Among them, 13 herbs were used with a frequency of ≥100, namely Dodder Seed, Polygonatum Sibiricum, Cornus Officinalis, Rehmannia Glutinosa, etc. The herbal temperature properties were mainly warm;the flavors were mainly sweet, bitter, and pungent;and the meridian affinities were primarily associated with the liver, spleen, and kidney meridians. Association rules and complex network diagrams revealed strong associations between herb combinations, such as Dodder Seed → Dipsacus Asperoides, Dodder Seed → Cornu Cervi Degelatinatum, Cornus Officinalis → Radix Pseudostellariae, and Salvia Miltiorrhiza. Cluster analysis classified the herbs into three categories: the first category was kidney-tonifying herbs, the second was blood-nourishing, spleen-invigorating, and liver-soothing herbs, and the third was blood-activating and stasis-resolving herbs. Conclusion: Director Zhao Ke’s treatment of hypomenorrhea due to TE is based on the principle of tonifying the kidney and regulating menstruation, nourishing blood and activating blood circulation, protecting the spleen and stomach, and applying both tonifying and replenishing methods. This approach aims to address the root cause of the disease while also addressing the symptoms, achieving a therapeutic effect that treats both the underlying pathology and the manifest symptoms.展开更多
文摘目的:基于数据挖掘分析赵珂主任治疗薄型子宫内膜(thin endometrium, TE)致月经过少的用药规律。方法:收集赵珂主任门诊的215首TE致月经过少的中药处方信息,对组成药物进行数据整理及科学性分析,录入Excel建立数据库,并运用SPSS软件建立的复杂网络系统,分析TE致月经量减少处方中的高频药物和配伍方法原理。结果:共纳入215首中药方剂,包括了165味中药,其中使用频次 ≥ 100的中药有13味,依次为菟丝子、黄精、山茱萸、熟地黄等。中药四气以温性为主;五味以甘、苦、辛为主;归经以肝、脾、肾经为主。关联规则及复杂网络图得出关联性强的药物组合为菟丝子→续断,菟丝子→鹿角霜,山茱萸→太子参、丹参。聚类分析可将药物分为3类,第1类为补肾类,第2类为养血健脾疏肝类,第3类为活血化瘀类。结论:赵珂主任治疗TE致月经过少以补肾调经为基本治则,养血活血,顾护脾胃,通补兼施。从而达到病机治本、病症治标的疗效。Objective: To analyze the medication patterns of Director Zhao Ke in treating hypomenorrhea due to thin endometrium (TE) based on data mining. Methods: Information from 215 Chinese herbal prescriptions for TE-induced hypomenorrhea from Director Zhao Ke’s outpatient clinic was collected. The constituent herbs were organized and analyzed scientifically, entered into an Excel database, and a complex network system established using SPSS software was utilized to analyze the high-frequency herbs and principles of compatibility in prescriptions for TE-induced hypomenorrhea. Results: A total of 215 Chinese herbal formulas were included, comprising 165 Chinese herbs. Among them, 13 herbs were used with a frequency of ≥100, namely Dodder Seed, Polygonatum Sibiricum, Cornus Officinalis, Rehmannia Glutinosa, etc. The herbal temperature properties were mainly warm;the flavors were mainly sweet, bitter, and pungent;and the meridian affinities were primarily associated with the liver, spleen, and kidney meridians. Association rules and complex network diagrams revealed strong associations between herb combinations, such as Dodder Seed → Dipsacus Asperoides, Dodder Seed → Cornu Cervi Degelatinatum, Cornus Officinalis → Radix Pseudostellariae, and Salvia Miltiorrhiza. Cluster analysis classified the herbs into three categories: the first category was kidney-tonifying herbs, the second was blood-nourishing, spleen-invigorating, and liver-soothing herbs, and the third was blood-activating and stasis-resolving herbs. Conclusion: Director Zhao Ke’s treatment of hypomenorrhea due to TE is based on the principle of tonifying the kidney and regulating menstruation, nourishing blood and activating blood circulation, protecting the spleen and stomach, and applying both tonifying and replenishing methods. This approach aims to address the root cause of the disease while also addressing the symptoms, achieving a therapeutic effect that treats both the underlying pathology and the manifest symptoms.
